Výsledky vyhledávání - "Sebastian Pons"

Akademický článek

Pathway-specific effects of ADSL deficiency on neurodevelopment

Autor: Ilaria Dutto, Julian Gerhards, Antonio Herrera, Olga Souckova, Václava Škopová, Jordann A Smak, Alexandra Junza, Oscar Yanes, Cedric Boeckx, Martin D Burkhalter, Marie Zikánová, Sebastian Pons, Melanie Philipp, Jens Lüders, Travis H Stracker

Publikováno v: eLife, Vol 11 (2022)

Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including microcephaly and autism spectrum disorder. ADSLD patients ha

Externí odkaz: https://doaj.org/article/5ef7d8baa9df4de681a7f4e9f3e46c1a

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Akademický článek

E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

Autor: Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastian Pons, Marian A Martinez-Balbas, Elisa Marti

Publikováno v: eLife, Vol 7 (2018)

Class II HLH proteins heterodimerize with class I HLH/E proteins to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting the neurogenic strength of the distinct proneural proteins. We find that inhibiting BMP signal

Externí odkaz: https://doaj.org/article/e8d4c42983b54f56a8fb66102ed7003a

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Pathway-specific effects of ADSL deficiency on neurodevelopment

Autor: Julian Gerhards, Ilaria Dutto, Antonio Herrera, Olga Souckova, Václava Škopová, Jordann A Smak, Alexandra Junza, Oscar Yanes, Cedric Boeckx, Martin D Burkhalter, Marie Zikánová, Sebastian Pons, Melanie Philipp, Jens Lüders, Travis H Stracker

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e3b1e33aefea47060e8952e6a4c97e
http://hdl.handle.net/10261/281196

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Author response: Pathway-specific effects of ADSL deficiency on neurodevelopment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::666ccb4f65769523f493da8a18681b83
https://doi.org/10.7554/elife.70518.sa2

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The Role of Smad2 in Adult Neuroplasticity as Seen through Hippocampal-Dependent Spatial Learning/Memory and Neurogenesis

Autor: Simona Gradari, Antonio Herrera, Patricia Tezanos, José Luis Trejo, Ángela Fontán-Lozano, Sebastian Pons

Publikováno v: J Neurosci
Digital.CSIC. Repositorio Institucional del CSIC
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© 2021 the authors
Adult neural plasticity is an important and intriguing phenomenon in the brain, and adult hippocampal neurogenesis is directly involved in modulating neural plasticity by mechanisms that are only partially understood. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24763c0614a46553ee413c24bd929da
http://hdl.handle.net/10261/254784

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Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity

Autor: Antonio Herrera, Andrea Ochoa, Blanca Torroba, Anghara Menendez, Sebastian Pons

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The Journal of Cell Biology

© 2021 Herrera et al.
The neural tube forms when neural stem cells arrange into a pseudostratified, single-cell–layered epithelium, with a marked apico-basal polarity, and in which adherens junctions (AJs) concentrate in the subapical domain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7f4e08b759b3e820b9f326089f2059
http://hdl.handle.net/10261/241513

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SAICAr-dependent and independent effects of ADSL deficiency on neurodevelopment

Autor: Alexandra Junza, Cedric Boeckx, Oscar Yanes, Sebastian Pons, Melanie Philipp, Jens Lüders, Burkhalter, Gerhards J, Ilaria Dutto, Antonio Herrera, Travis H. Stracker

Adenylosuccinate Lyase (ADSL) functions in the de novo purine biosynthesis pathway. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including microcephaly and autism spectrum disorder. ADSLD patients have normal purine nucleot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dabad3eac00bb45fe29500f1adaa68
https://doi.org/10.1101/2020.11.23.394767

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β-Catenin tumour-suppressor activity depends on its ability to promote Pro-N-Cadherin maturation

Autor: Sebastian Pons, Anghara Menendez, Blanca Torroba, Antonio J. Herrera

SUMMARYNeural stem cells (NSCs) form a pseudostratified, single-cell layered epithelium with a marked apico-basal polarity. In these cells, β-Catenin associates with classic cadherins in order to form the apical adherens junctions (AJs). We previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94784bc787db2d89bd31dba6a0e939f3
https://doi.org/10.1101/571810

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Influence of core extension and side chain nature in targeting G-quadruplex structures with perylene monoimide derivatives

Autor: Tomás Torroba, José García-Calvo, Sebastian Pons, Jean-Louis Mergny, Begoña García, Natalia Busto, Antonio Herrera, José V. Cuevas

Publikováno v: Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC

A structure–activity relationship (SAR) study in terms of G-quadruplex binding ability and antiproliferative activity of six fluorescent perylenemonoimide (PMIs) derivatives is reported. A positive charge seems to be the key to target G4. This stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c0807ea328ee05d2ad3dd1fb6cf111
https://doi.org/10.1016/j.bioorg.2021.104660

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