Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sebastian Nehring"'
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e31992 (2012)
The suppression of amber stop codons with non-canonical amino acids (ncAAs) is used for the site-specific introduction of many unusual functions into proteins. Specific orthogonal aminoacyl-tRNA synthetase (o-aaRS)/amber suppressor tRNA(CUA) pairs (o
Externí odkaz:
https://doaj.org/article/108a16c446b1496fb3cd98f6b6e8d974
Autor:
Lukas Berger, Robina M. Meyer, Sebastian Nehring, Joerg Nerkamp, Wolfgang Friess, Stefan Scheler
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 160:134-142
Monoclonal antibodies (mAbs) are valuable tools both in therapy and in diagnostic. Their tendency to aggregate is a serious concern. Since a mAb drug substance (DS) is composed of different variants, it is important for manufacturers to know the beha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11207a6dc4a754201069c4fbe2410c9f
https://doi.org/10.1016/j.ejpb.2021.01.006
https://doi.org/10.1016/j.ejpb.2021.01.006
Autor:
Lukas Berger, Wolfgang Friess, Stefan Scheler, Robina M. Meyer, Sebastian Nehring, Joerg Nerkamp
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 158
Biopharmaceutical products contain conformational and chemical variants, that are typically well characterized regarding identity and activity. However, little is known about their self-interaction propensity and tendency to unfold, which are critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02d956edb76b44a1801829296c9372b
https://pubmed.ncbi.nlm.nih.gov/33221370
https://pubmed.ncbi.nlm.nih.gov/33221370
Autor:
Christina Wolschner, Marina Royter, Carlos G. Acevedo-Rocha, Nediljko Budisa, Birgit Wiltschi, Michael G. Hoesl, Sebastian Nehring, Garabed Antranikian
Publikováno v:
ChemCatChem. 3:213-221
Classical enzyme optimization exploits the chemistry confined to the 20 canonical amino acids encoded by the standard genetic code. ‘Genetic code engineering’ allows the global substitution of particular residues with synthetic analogues, endowin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95bc7ecd5e03e227459afaf863a30cbc
https://doi.org/10.1002/cctc.201000253
https://doi.org/10.1002/cctc.201000253
Publikováno v:
Nature Structural & Molecular Biology. 14:647-652
To reveal the mechanism of processive strand separation by superfamily-2 (SF2) 3'--5' helicases, we determined apo and DNA-bound crystal structures of archaeal Hel308, a helicase that unwinds lagging strands and is related to human DNA polymerase the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eab5e7904e281ef21e3205722e1732e
https://doi.org/10.1038/nsmb1246
https://doi.org/10.1038/nsmb1246
Publikováno v:
Yeast (Chichester, England). 25(11)
We replaced the single N-terminal methionine in heterologously expressed human Cu/Zn superoxide dismutase with the non-canonical methionine analogues homopropargylglycine and norleucine in the yeast Saccharomyces cerevisiae. Our non-canonical amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d4ffba2d32c31206e6e58aca23a6aa
https://pubmed.ncbi.nlm.nih.gov/19061186
https://pubmed.ncbi.nlm.nih.gov/19061186
Autor:
Birgit Wiltschi, Michael Georg Hoesl, Marina Royter, Garabed Antranikian, Nediljko Budisa, Sebastian Nehring, Christina Wolschner, Carlos G. Acevedo-Rocha
Publikováno v:
Catalysis Science & Technology. 3:1198
The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to 450%) and surfactants (resp. 1630%), but also protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82061bb190f9fb59bcba91ef127e840
https://doi.org/10.1039/c3cy20712a
https://doi.org/10.1039/c3cy20712a