Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Sebastian Michels"'
Autor:
Florian Malchers, Lucia Nogova, Martijn H.A. van Attekum, Lukas Maas, Johannes Brägelmann, Christoph Bartenhagen, Luc Girard, Graziella Bosco, Ilona Dahmen, Sebastian Michels, Clare E. Weeden, Andreas H. Scheel, Lydia Meder, Kristina Golfmann, Philipp Schuldt, Janna Siemanowski, Jan Rehker, Sabine Merkelbach-Bruse, Roopika Menon, Oliver Gautschi, Johannes M. Heuckmann, Elisabeth Brambilla, Marie-Liesse Asselin-Labat, Thorsten Persigehl, John D. Minna, Henning Walczak, Roland T. Ullrich, Matthias Fischer, Hans Christian Reinhardt, Jürgen Wolf, Reinhard Büttner, Martin Peifer, Julie George, Roman K. Thomas
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplification (detecte
Externí odkaz:
https://doaj.org/article/ef6247e9f6b84dbca5a0844486ed3d80
Autor:
Ya Cui, Frederick J. Arnold, Fanglue Peng, Dan Wang, Jason Sheng Li, Sebastian Michels, Eric J. Wagner, Albert R. La Spada, Wei Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Alternative polyadenylation (APA) contributes to the post-transcriptional regulation of most human genes, yet the effects of APA are largely overlooked by conventional transcriptome-wide association studies (TWAS). Here, the authors conduct an APA-TW
Externí odkaz:
https://doaj.org/article/3b9acc93f1604e6d9cce16b07c9ad72d
Autor:
Diana Schaufler, David F. Ast, Hannah L. Tumbrink, Nima Abedpour, Lukas Maas, Ayla E. Schwäbe, Inga Spille, Stefanie Lennartz, Jana Fassunke, Mihaela Aldea, Benjamin Besse, David Planchard, Lucia Nogova, Sebastian Michels, Carsten Kobe, Thorsten Persigehl, Theresa Westphal, Sophia Koleczko, Rieke Fischer, Jan-Phillip Weber, Janine Altmüller, Roman K. Thomas, Sabine Merkelbach-Bruse, Oliver Gautschi, Laura Mezquita, Reinhard Büttner, Jürgen Wolf, Martin Peifer, Johannes Brägelmann, Matthias Scheffler, Martin L. Sos
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-12 (2021)
Abstract Activation of MAPK signaling via BRAF mutations may limit the activity of EGFR inhibitors in EGFR-mutant lung cancer patients. However, the impact of BRAF mutations on the selection and fitness of emerging resistant clones during anti-EGFR t
Externí odkaz:
https://doaj.org/article/2fe94ce5763c49248add719a2c82fe60
Autor:
Lu Tang, Johannes Dorst, Lu Chen, Xiaolu Liu, Yan Ma, Kornelia Günther, Sebastian Michels, Kathrin Müller, Axel Freischmidt, Jochen H. Weishaupt, Dongsheng Fan, Albert C. Ludolph
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/341543cf9e034ae79a9d9d0e543d2b55
Autor:
Svenja Wagener-Ryczek, Carina Heydt, Juliane Süptitz, Sebastian Michels, Markus Falk, Christina Alidousty, Jana Fassunke, Michaela Angelika Ihle, Markus Tiemann, Lukas Heukamp, Jürgen Wolf, Reinhard Büttner, Sabine Merkelbach-Bruse
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Over the past years, EGFR tyrosine kinase inhibitors (TKI) revolutionized treatment response. 1st-generation (reversible) EGFR TKI and later the 2nd –generation irreversible EGFR TKI Afatinib were aimed to improve treatment resp
Externí odkaz:
https://doaj.org/article/f7936ba47ab04f9d9e1b464f58d1640a
Autor:
Florian Rosar, Hans-Georg Buchholz, Sebastian Michels, Manuela A. Hoffmann, Markus Piel, Christopher M. Waldmann, Frank Rösch, Stefan Reuss, Mathias Schreckenberger
Publikováno v:
EJNMMI Physics, Vol 7, Iss 1, Pp 1-17 (2020)
Abstract Background 44Sc has been increasingly investigated as a potential alternative to 68Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of 44Sc (0.63 MeV) compared to 68Ga (0.83 MeV) can res
Externí odkaz:
https://doaj.org/article/c7f7458b7f394c2cb0b0c2c49ca6420c
Autor:
Johannes Dorst, Tanja Fangerau, Daniela Taranu, Pia Eichele, Jens Dreyhaupt, Sebastian Michels, Joachim Schuster, Albert C Ludolph, Makbule Senel, Hayrettin Tumani
Publikováno v:
EClinicalMedicine, Vol 16, Iss , Pp 98-106 (2019)
Summary: Background: Plasma exchange (PE) constitutes the standard therapy for steroid-refractory relapse in multiple sclerosis and clinically isolated syndrome. Immunoadsorption (IA) is an alternative method of apheresis which selectively removes im
Externí odkaz:
https://doaj.org/article/57a9673eda874dea8734dcc665852978
Autor:
Sebastian Michels, Hans-Georg Buchholz, Florian Rosar, Isabel Heinrich, Manuela A. Hoffmann, Susann Schweiger, Oliver Tüscher, Mathias Schreckenberger
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-4 (2019)
Abstract Background Huntington’s disease (HD) is a rare, genetic neurodegenerative disorder often presenting with emotional, cognitive and behavioral abnormalities before manifestation of disease defining motor symptoms. Cognitive impairment is a f
Externí odkaz:
https://doaj.org/article/1fb173246efb4f1998d370aaa98cc596
Autor:
Jana Fassunke, Fabienne Müller, Marina Keul, Sebastian Michels, Marcel A. Dammert, Anna Schmitt, Dennis Plenker, Jonas Lategahn, Carina Heydt, Johannes Brägelmann, Hannah L. Tumbrink, Yannic Alber, Sebastian Klein, Alena Heimsoeth, Ilona Dahmen, Rieke N. Fischer, Matthias Scheffler, Michaela A. Ihle, Vanessa Priesner, Andreas H. Scheel, Svenja Wagener, Anna Kron, Konrad Frank, Katia Garbert, Thorsten Persigehl, Michael Püsken, Stefan Haneder, Bernhard Schaaf, Ernst Rodermann, Walburga Engel-Riedel, Enriqueta Felip, Egbert F. Smit, Sabine Merkelbach-Bruse, H. Christian Reinhardt, Stefan M. Kast, Jürgen Wolf, Daniel Rauh, Reinhard Büttner, Martin L. Sos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Acquired resistance to targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. Here, the authors show how the acquired EGFR G724S mutation induces resistance to third-generation EGFR inhibitors and why the mutant kinase rem
Externí odkaz:
https://doaj.org/article/d0509a8e9f1241e6a692b9bd9e5d0a9b
Autor:
Luise Appeltshauser, Helena Junghof, Julia Messinger, Janis Linke, Axel Haarmann, Ilya Ayzenberg, Panoraia Baka, Johannes Dorst, Anna L Fisse, Thomas Grüter, Valerie Hauschildt, Alexander Jörk, Frank Leypoldt, Mathias Mäurer, Edgar Meinl, Sebastian Michels, Jeremias Motte, Kalliopi Pitarokoili, Mark Stettner, Carmen Villmann, Marc Weihrauch, Gabriel S Welte, Inga Zerr, Katrin G Heinze, Claudia Sommer, Kathrin Doppler
Publikováno v:
Brain 146(5), 1932-1949 (2023). doi:10.1093/brain/awac418
Autoimmune neuropathy associated with antibodies against pan-neurofascin is a new subtype of nodo-paranodopathy. It is relevant because it is associated with high morbidity and mortality. Affected patients often require intensive care unit treatment