Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sebastian Mackedenski"'
Autor:
Almas Yaqoob, Wai Ming Li, Victor Liu, Chuyi Wang, Sebastian Mackedenski, Linda E Tackaberry, Hugues B Massicotte, Keith N Egger, Kerry Reimer, Chow H Lee
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0231948 (2020)
In our search for bioactive mushrooms native to British Columbia, we determined that the ethanol extracts from fruiting bodies of the terrestrial polypore Albatrellus flettii had potent anti-cell viability activity. Using bioassay-guided fractionatio
Externí odkaz:
https://doaj.org/article/f83507ec20ab40c89e622dbc041bb0fc
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171196 (2017)
Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340. Here, we aim to further understand the molecular interaction between
Externí odkaz:
https://doaj.org/article/668c00a16c554f28993b6864b5047a42
Publikováno v:
Nehme, J, Borghesan, M, Mackedenski, S, Bird, T G & Demaria, M 2020, ' Cellular senescence as a potential mediator of COVID-19 severity in the elderly ', Aging Cell, vol. 19, no. 10, e13237 . https://doi.org/10.1111/acel.13237, https://doi.org/10.1111/acel.v19.10
Aging Cell
Aging Cell
SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome. Epidemiological data show that COVID‐19 has a rising mortality particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60072857ed3319030a68f7728404f6f
https://hdl.handle.net/20.500.11820/dddc9adf-7b7a-42ae-a7b5-41af846bd25d
https://hdl.handle.net/20.500.11820/dddc9adf-7b7a-42ae-a7b5-41af846bd25d
Autor:
Keith N. Egger, Hugues B. Massicotte, Wai Ming Li, Linda E. Tackaberry, Sebastian Mackedenski, Chuyi Wang, Kerry B. Reimer, Victor Liu, Chow H. Lee, Almas Yaqoob
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0231948 (2020)
PLoS ONE, Vol 15, Iss 5, p e0231948 (2020)
In our search for bioactive mushrooms native to British Columbia, we determined that the ethanol extracts from fruiting bodies of the terrestrial polypore Albatrellus flettii had potent anti-cell viability activity. Using bioassay-guided fractionatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e3f473ecdd598d5d0f4fe0b6a6e5ce
http://europepmc.org/articles/PMC7199964
http://europepmc.org/articles/PMC7199964
Publikováno v:
Biochemical Journal. 475:2749-2767
Insulin-like growth factor 2 mRNA-binding protein-1 (IMP1) has high affinity for KRAS mRNA, and it can regulate KRAS expression in cells. We first characterized the molecular interaction between IMP1 and KRAS mRNA. Using IMP1 variants with a point mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b8c6595ae2ab66c8316d9df9805aac
https://doi.org/10.1042/bcj20180575
https://doi.org/10.1042/bcj20180575
Autor:
Wai Ming Li, Ankush Barad, Linda E. Tackaberry, Chow H. Lee, Bryan Chu Chwen Lim, Xiaojie Li, Keith N. Egger, Faran Rashid, Kerry B. Reimer, Hugues B. Massicotte, Sebastian Mackedenski, Peter C.K. Cheung
Publikováno v:
Carbohydrate polymers. 181
A growth-inhibitory polysaccharide (GIPinv) was purified using size-exclusion and ion-exchange chromatography from the fourth sodium hydroxide extraction step of a fungus found in British Columbia. The fungus was genetically identified as a member of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d1c74adbaed8b19254ee904069f7e9
https://pubmed.ncbi.nlm.nih.gov/29254055
https://pubmed.ncbi.nlm.nih.gov/29254055
Publikováno v:
Molecular pharmacology. 89(6)
The stabilization of glioma-associated oncogene 1 (GLI1) mRNA by coding region determinant binding protein (CRD-BP) through the Wnt/β-catenin signaling pathway is implicated in the proliferation of colorectal cancer and basal cell carcinoma. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1959ee6466ccd2b27a1077bc5a7adf
https://pubmed.ncbi.nlm.nih.gov/27207839
https://pubmed.ncbi.nlm.nih.gov/27207839
Autor:
Andrew L. Miller, Ching-Man Chan, Mark Barnes, Chowhwee Lee, Gerrit van Rensburg, Dustin T. King, Wai-Ming Li, Sebastian Mackedenski, Kashif Mehmood
The ability of its four heterogeneous nuclear RNP-K-homology (KH) domains to physically associate with oncogenic mRNAs is a major criterion for the function of the coding region determinant-binding protein (CRD-BP). However, the particular RNA-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a49ca1f700c93534c0a93c63ebdd22c
https://europepmc.org/articles/PMC4281763/
https://europepmc.org/articles/PMC4281763/
Publikováno v:
Journal of molecular biology. 427(2)
Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant mammalian enzyme in DNA base excision repair pathway that cleaves the DNA backbone immediately 5' to abasic sites. In addition to its abasic endonuclease activity, APE1 has 3' phosphatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04ba8a24c23a0474a3585fde9424854
https://pubmed.ncbi.nlm.nih.gov/25498387
https://pubmed.ncbi.nlm.nih.gov/25498387
Autor:
Sebastian Mackedenski, Chow H. Lee
Publikováno v:
Cancer Research. 75:2133-2133
The Coding Region Determinant-Binding Protein (CRD-BP) is an RNA-binding protein which, among other functions, provides a protective effect for select target mRNA transcripts against degradation, effectively increasing their half-life leading to elev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d24e983ee82d6eeeedc4d3d5e4d12d4d
https://doi.org/10.1158/1538-7445.am2015-2133
https://doi.org/10.1158/1538-7445.am2015-2133