Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sebastian M. Dieter"'
Autor:
Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter, Remco Nagel, Jin Ma, Abhijeet Pataskar, Gozde Korkmaz, Ran Elkon, Miao-Ping Chien, Li You, Pin-Rui Su, Onno B. Bleijerveld, Maarten Altelaar, Lyubomir Momchev, Zohar Manber, Ruiqi Han, Pieter C. van Breugel, Rui Lopes, Peter ten Dijke, Jacco van Rheenen, Reuven Agami
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-28 (2021)
Abstract Background Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thous
Externí odkaz:
https://doaj.org/article/c775eb768cb945179e71e99f571ae872
Autor:
Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm, Claudia R. Ball
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the mechanisms regulating
Externí odkaz:
https://doaj.org/article/ba1aaeb46e174969b3e687ece0a945c4
Autor:
Felix Bormann, Manuel Rodríguez-Paredes, Felix Lasitschka, Dominic Edelmann, Tanja Musch, Axel Benner, Yehudit Bergman, Sebastian M. Dieter, Claudia R. Ball, Hanno Glimm, Heinz G. Linhart, Frank Lyko
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3407-3418 (2018)
Summary: Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, prov
Externí odkaz:
https://doaj.org/article/e86c318f3a9a4f9bb5b8774c69ab0e1e
Autor:
Karl Roland Ehrenberg, Jianpeng Gao, Felix Oppel, Stephanie Frank, Na Kang, Tim Kindinger, Sebastian M. Dieter, Friederike Herbst, Lino Möhrmann, Taronish D. Dubash, Erik R. Schulz, Hendrik Strakerjahn, Klara M. Giessler, Sarah Weber, Ava Oberlack, Eva-Maria Rief, Oliver Strobel, Frank Bergmann, Felix Lasitschka, Jürgen Weitz, Hanno Glimm, Claudia R. Ball
Publikováno v:
Cells, Vol 8, Iss 2, p 142 (2019)
In highly aggressive malignancies like pancreatic cancer (PC), patient-derived tumor models can serve as disease-relevant models to understand disease-related biology as well as to guide clinical decision-making. In this study, we describe a two-step
Externí odkaz:
https://doaj.org/article/1256f87644bb43a386fa5d4e662c089e
Autor:
Sebastian M. Dieter, Domenica Lovecchio, Abhijeet Pataskar, Martina K. Zowada, Pierre-René Körner, Anna Khalizieva, Olaf van Tellingen, Dirk Jäger, Hanno Glimm, Reuven Agami
Publikováno v:
Oncogene, 41(32), 3953-3968. Nature Publishing Group
Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its paralog TAZ in resistance to multiple tar
Autor:
Claudia R Ball, Felix Oppel, Karl Roland Ehrenberg, Taronish D Dubash, Sebastian M Dieter, Christopher M Hoffmann, Ulrich Abel, Friederike Herbst, Moritz Koch, Jens Werner, Frank Bergmann, Naveed Ishaque, Manfred Schmidt, Christof von Kalle, Claudia Scholl, Stefan Fröhling, Benedikt Brors, Wilko Weichert, Jürgen Weitz, Hanno Glimm
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 918-932 (2017)
Abstract Although tumor‐initiating cell (TIC) self‐renewal has been postulated to be essential in progression and metastasis formation of human pancreatic adenocarcinoma (PDAC), clonal dynamics of TICs within PDAC tumors are yet unknown. Here, we
Externí odkaz:
https://doaj.org/article/806e5c3796d448e3a3f8956eba08fa15
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 856-858 (2017)
Abstract Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells)
Externí odkaz:
https://doaj.org/article/b4d8be118cce48e187cdd3b6d3dc4afa
Autor:
Ava Oberlack, Mathias Kalxdorf, Katharina Jechow, Mark Kriegsmann, Stephan M Tirier, Jeroen Krijgsveld, Christian Conrad, Roland Eils, Karin Laaber, Torsten Müller, Teresa G Krieger, Martin Schneider, Friederike Herbst, Mario Huerta, Sebastian M. Dieter, Claudia R. Ball, Robert Lorenz Chua, Foo Wei Ten, Martina K. Zowada, Katharina Kriegsmann, Jeongbin Park, Hanno Glimm
Publikováno v:
Cancers, Vol 13, Iss 1097, p 1097 (2021)
Cancers
Volume 13
Issue 5
Cancers
Volume 13
Issue 5
Simple Summary Different types of cells with tumor-initiating cell (TIC) activity contribute to colorectal cancer (CRC) progression and resistance to anti-cancer treatment. In this study, we aimed to understand whether different cell types exist with
Autor:
Martin Lange, Erik Schulz, Mario Huerta, Mona Blatter, Ali Nowrouzi, Bernhard Kuster, Ulrike Uhrig, Karin Laaber, Axel Benner, Hanno Glimm, Claudia R. Ball, Sina Kreth, Dominik Mumberg, Kerstin Putzker, Friederike Herbst, Joerg Weiske, Hannes Hahne, Sarah Johannes, Gerhard Siemeister, Frank Westermann, Andrea Haegebarth, Martina K. Zowada, Gabriele Stoehr, Simon Holton, Paula L Codo, Joe Lewis, Sebastian M. Dieter, Ulrike Scheib, Lena-Marit Toepper, Sylvia Martin, Christine Siegl, Anna L. Ostermann-Parucha
Summary Novel treatment options for metastatic colorectal cancer (CRC) are urgently needed to improve patient outcome. Here, we screen a library of non-characterized small molecules against a heterogeneous collection of patient-derived CRC spheroids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410f992a87b35fec1505c6f97a79632
https://mediatum.ub.tum.de/doc/1652086/document.pdf
https://mediatum.ub.tum.de/doc/1652086/document.pdf
Autor:
Friederike Herbst, Katharina Kriegsmann, Christine Siegl, Sebastian M. Dieter, Hendrik Strakerjahn, Martin Schneider, Mark Kriegsmann, Claudia R. Ball, Lino Möhrmann, Martina K. Zowada, Hanno Glimm, Annette Kopp-Schneider, Dirk Strunk, Damir Krunic
Publikováno v:
International journal of cancerReferences. 147(2)
Disseminated tumor cells (dTCs) can frequently be detected in the bone marrow (BM) of colorectal cancer (CRC) patients, raising the possibility that the BM serves as a reservoir for metastatic tumor cells. Identification of dTCs in BM aspirates harbo