Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sebastian M B Nijman"'
Autor:
Barbara Mair, Tomasz Konopka, Claudia Kerzendorfer, Katia Sleiman, Sejla Salic, Violeta Serra, Markus K Muellner, Vasiliki Theodorou, Sebastian M B Nijman
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006279 (2016)
Patterns of somatic mutations in cancer genes provide information about their functional role in tumourigenesis, and thus indicate their potential for therapeutic exploitation. Yet, the classical distinction between oncogene and tumour suppressor may
Externí odkaz:
https://doaj.org/article/bca218518bad4ab88318e85224b8d950
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31003 (2012)
BACKGROUND:Phosphorylation by the phospho-inositide-dependent kinase 1 (PDK1) is essential for many growth factor-activated kinases and thus plays a critical role in various processes such as cell proliferation and metabolism. However, the mechanisms
Externí odkaz:
https://doaj.org/article/8c938c4a09a042fc805e3404f0b9b7eb
Autor:
Andrea Perne, Markus K Muellner, Magdalena Steinrueck, Nils Craig-Mueller, Julia Mayerhofer, Ilse Schwarzinger, Mathew Sloane, Iris Z Uras, Gregor Hoermann, Sebastian M B Nijman, Matthias Mayerhofer
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8292 (2009)
BACKGROUND:Cardiac glycosides are Na(+)/K(+)-pump inhibitors widely used to treat heart failure. They are also highly cytotoxic, and studies have suggested specific anti-tumor activity leading to current clinical trials in cancer patients. However, a
Externí odkaz:
https://doaj.org/article/56333376f154435899319fc91d9ee048
Autor:
Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z. Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M. Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K. Muellner, Zsuzsanna Bago-Horvath, Eric B. Haura, Joanna I. Loizou, Sebastian M. B. Nijman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modu
Externí odkaz:
https://doaj.org/article/d580c8bada764855b9d9cdb7d5d53e6b
Publikováno v:
Science (New York, N.Y.). 342(6160)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31b62ae7b28c5c1d1a79488ce863975a
https://pubmed.ncbi.nlm.nih.gov/24233712
https://pubmed.ncbi.nlm.nih.gov/24233712
Publikováno v:
Methods in enzymology. 398
Protein ubiquitination is a dynamic process, depending on a tightly regulated balance between the activity of ubiquitin ligases and their antagonists, the ubiquitin-specific proteases or deubiquitinating enzymes. The family of ubiquitin ligases has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5c083cbe97eaad63073f8c958848902
https://pubmed.ncbi.nlm.nih.gov/16275358
https://pubmed.ncbi.nlm.nih.gov/16275358