Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Sebastian Kracun"'
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Akademický článek
Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells.
Autor: Paraskevi Krashia, Mirko Moroni, Steven Broadbent, Giovanna Hofmann, Sebastian Kracun, Marco Beato, Paul J Groot-Kormelink, Lucia G Sivilotti
Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13611 (2010)
The neuronal nicotinic receptors that mediate excitatory transmission in autonomic ganglia are thought to be formed mainly by the α3 and β4 subunits. Expressing this composition in oocytes fails to reproduce the properties of ganglionic receptors,
Externí odkaz: https://doaj.org/article/4d77485c365f4a4fb7ce408a1faa24d7
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2
Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway
Autor: Jonathan S. Marvin, Sebastian Kracun, Ji Xu, Baljit S. Khakh, Xiaoping Tong, Mark H. Ellisman, Xiao-Hong Lu, Thomas J. O'Dell, X. William Yang, Eric A. Bushong, Olan Jackson-Weaver, Tiffany Shih, Loren L. Looger, Martin D. Haustein
Publikováno v: Neuron, vol 82, iss 2
SummaryThe spatiotemporal activities of astrocyte Ca2+ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca2+ and glutamate indicators as well as pharmacogenetic and electrical control of neurotransmitter release to ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d3e5741fd008ae89f62cb13862ec14
https://doi.org/10.1016/j.neuron.2014.02.041
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4
A genetically targeted optical sensor to monitor calcium signals in astrocyte processes
Autor: Eiji Shigetomi, Baljit S. Khakh, Sebastian Kracun, Michael V. Sofroniew
Publikováno v: Nature Neuroscience. 13:759-766
Calcium signaling is studied as a potential form of astrocyte excitability that may control astrocyte involvement in synaptic and cerebrovascular regulation. Fundamental questions remain unanswered about astrocyte calcium signaling, as current method
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c38c73b150473dd06784e5d1e35e5bc
https://doi.org/10.1038/nn.2557
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5
Gated Access to the Pore of a P2X Receptor
Autor: Sebastian Kracun, Vincent Chaptal, Jeff Abramson, Baljit S. Khakh
Publikováno v: Journal of Biological Chemistry. 285:10110-10121
P2X receptors are ligand-gated cation channels that transition from closed to open states upon binding ATP. The crystal structure of the closed zebrafish P2X4.1 receptor directly reveals that the ion-conducting pathway is formed by three transmembran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3595872e49097ba8dddfe7693fc9336a
https://doi.org/10.1074/jbc.m109.089185
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6
Inhibition of the α9α10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-d-aspartate receptors
Autor: Ana Belén Elgoyhen, Paola V. Plazas, Eleonora Katz, Sebastian Kracun, María Eugenia Gómez-Casati, Jessica Savino, Neil S. Millar, Chris G. Parsons
Publikováno v: European Journal of Pharmacology. 566:11-19
In this study we report the effects of neramexane, a novel amino-alkyl-cyclohexane derivative that is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, on recombinant rat α9α10 nicotinic acetylcholine receptors expressed in Xenopus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c82059bd01b5be0073bcc16146fb99
https://doi.org/10.1016/j.ejphar.2007.03.026
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7
Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses
Autor: Sebastian Kracun, Ji Xu, Baljit S. Khakh, Martin D. Haustein, Eiji Shigetomi, Eric A. Bushong, Mark H. Ellisman, Michael V. Sofroniew, Xiaoping Tong, Olan Jackson-Weaver
Publikováno v: The Journal of General Physiology
Intracellular Ca2+ transients are considered a primary signal by which astrocytes interact with neurons and blood vessels. With existing commonly used methods, Ca2+ has been studied only within astrocyte somata and thick branches, leaving the distal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609d7ece1815334a304047a058e280ba
https://pubmed.ncbi.nlm.nih.gov/23589582
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8
Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells
Autor: Steven D. Broadbent, Giovanna Hofmann, Paraskevi Krashia, Mirko Moroni, Sebastian Kracun, Paul J. Groot-Kormelink, Lucia G. Sivilotti, Marco Beato
Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13611 (2010)
PLoS ONE
Background: The neuronal nicotinic receptors that mediate excitatory transmission in autonomic ganglia are thought to be formed mainly by the alpha 3 and beta 4 subunits. Expressing this composition in oocytes fails to reproduce the properties of gan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede160d6fc3252c89505afe64ceede0f
http://europepmc.org/articles/PMC2964301?pdf=render
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9
Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters
Autor: Sebastian Kracun, Baljit S. Khakh, Eiji Shigetomi
Astrocytes are involved in synaptic and cerebrovascular regulation in the brain. These functions are regulated by intracellular calcium signalling that is thought to reflect a form of astrocyte excitability. In a recent study, we reported modificatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8d687ae02ca9cab9e00e4c3cd0c6e3
https://europepmc.org/articles/PMC3136572/
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