Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sebastian Koochaki"'
Autor:
Zuzana Tothova, Anne-Laure Valton, Rebecca A. Gorelov, Mounica Vallurupalli, John M. Krill-Burger, Amie Holmes, Catherine C. Landers, J. Erika Haydu, Edyta Malolepsza, Christina Hartigan, Melanie Donahue, Katerina D. Popova, Sebastian Koochaki, Sergey V. Venev, Jeanne Rivera, Edwin Chen, Kasper Lage, Monica Schenone, Alan D. D’Andrea, Steven A. Carr, Elizabeth A. Morgan, Job Dekker, Benjamin L. Ebert
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myelo
Externí odkaz:
https://doaj.org/article/04d99d4ec50c41c1a8bc57f790a16758
Autor:
Christina R. Hartigan, Benjamin L. Ebert, Caroline Stanclift, Namrata D. Udeshi, Monica Schenone, Amanuel Bizuayehu, Veronica Kovalcik, Tanya Svinkina, Alexis Vedder, Marie McConkey, Eric Padron, Sebastian Koochaki, Roger Belizaire, Steven A. Carr, Lei Sun
Publikováno v:
Blood
Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in myeloid neoplasms, including 10% to 20% of chronic myelomonocytic leukemi
Autor:
Christina R. Hartigan, John M. Krill-Burger, Jeanne F Rivera, Catherine C. Landers, Sergey V. Venev, Steven A. Carr, Rebecca A. Gorelov, Edwin Chen, Elizabeth A. Morgan, Alan D. D'Andrea, Job Dekker, Mounica Vallurupalli, Edyta Malolepsza, Katerina D. Popova, Amie Holmes, Kasper Lage, Anne-Laure Valton, J. Erika Haydu, Monica Schenone, Melanie Donahue, Sebastian Koochaki, Zuzana Tothova, Benjamin L. Ebert
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
JCI Insight
JCI Insight
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myelo
Autor:
Caroline Stanclift, Roger Belizaire, Tanya Svinkina, Alexis Vedder, Christina R. Hartigan, Steven A. Carr, Sebastian Koochaki, Benjamin L. Ebert, Lei Sun, Monica Schenone, Eric Padron, Namrata D. Udeshi
CBL encodes an E3 ubiquitin ligase and signaling adaptor that acts downstream of cytokine receptors. Recurrent CBL mutations occur in myeloid malignancies, but the mechanism by which these mutations drive oncogenesis remains incompletely understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaeb73dbda9ed918a96fa4fb120ee36c
https://doi.org/10.1101/2020.04.13.038448
https://doi.org/10.1101/2020.04.13.038448
Autor:
Monica Schenone, Roger Belizaire, Eric Padron, Alexis Vedder, Lei Sun, Namrata D. Udeshi, Steven A. Carr, Benjamin L. Ebert, Sebastian Koochaki
Publikováno v:
Blood. 134:563-563
CBL encodes an E3 ubiquitin ligase and signaling adaptor that acts downstream of cytokine receptors. Recurrent CBL mutations are found in a variety of myeloid disorders, including 10-15% of chronic myelomonocytic leukemia (CMML) cases, and specifical
Autor:
Steven A. Carr, Catherine C. Landers, Jeanne F Rivera, Zuzana Tothova, Monica Schenone, Denes Hnisz, Edwin Chen, Benjamin L. Ebert, Katerina D. Popova, Melanie Donahue, Amie Holmes, Christina R. Hartigan, Brian J. Abraham, Richard A. Young, Michael Seiler, Daniel S. Day, Sebastian Koochaki, J. Erika Haydu, Alan D. D'Andrea, Silvia Buonamici, John M. Krill-Burger, Edyta Malolepsza
Publikováno v:
Blood. 132:940-940
Recurrent somatic mutations in core components and modulators of the cohesin ring - a multimeric protein complex that forms a ring structure around DNA and provides spatial genome organization - have been identified across multiple cancer types, incl
Autor:
Alex George, Diamantis G. Konstantinidis, Sebastian Koochaki, Narla Mohandas, Yi Zheng, Suvarnamala Pushkaran, Theodosia A. Kalfa, Punam Malik, Clinton H. Joiner
Publikováno v:
Blood. 121:2099-2107
Chronic inflammation has emerged as an important pathogenic mechanism in sickle cell disease (SCD). One component of this inflammatory response is oxidant stress mediated by reactive oxygen species (ROS) generated by leukocytes, endothelial cells, pl
Autor:
Sebastian Koochaki, Alex George, Narla Mohandas, Yi Zheng, Suvarnamala Pushkaran, Clinton H. Joiner, Theodosia A. Kalfa
Publikováno v:
Blood. 116:1634-1634
Abstract 1634 Chronic inflammation has emerged as an important pathogenic mechanism in sickle cell disease. One component of this inflammatory response is oxidant stress mediated by reactive oxygen species (ROS) generated by leukocytes, endothelial c