Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Sebastian Kobold"'
Autor:
Florian Märkl, Christoph Schultheiß, Murtaza Ali, Shih-Shih Chen, Marina Zintchenko, Lukas Egli, Juliane Mietz, Obinna Chijioke, Lisa Paschold, Sebastijan Spajic, Anne Holtermann, Janina Dörr, Sophia Stock, Andreas Zingg, Heinz Läubli, Ignazio Piseddu, David Anz, Marcus Dühren-von Minden, Tianjiao Zhang, Thomas Nerreter, Michael Hudecek, Susana Minguet, Nicholas Chiorazzi, Sebastian Kobold, Mascha Binder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they
Externí odkaz:
https://doaj.org/article/f556d70ecba646069501e54817da7995
Autor:
Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela F. Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Remi Doucet-Ladevèze, Werner Schmitz, Bart Ghesquière, Sebastian Theurich, Jan Dudek, Georg Gasteiger, Alma Zernecke, Sebastian Kobold, Wolfgang Kastenmüller, Martin Vaeth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precu
Externí odkaz:
https://doaj.org/article/8569ec630ff141898b05f8e21eb43d82
Autor:
Tao Xu, Philipp Karschnia, Bruno Loureiro Cadilha, Sertac Dede, Michael Lorenz, Niklas Seewaldt, Elene Nikolaishvili, Katharina Müller, Jens Blobner, Nico Teske, Julika J. Herold, Kai Rejeski, Sigrid Langer, Hannah Obeck, Theo Lorenzini, Matthias Mulazzani, Wenlong Zhang, Hellen Ishikawa-Ankerhold, Veit R. Buchholz, Marion Subklewe, Niklas Thon, Andreas Straube, Joerg-Christian Tonn, Sebastian Kobold, Louisa von Baumgarten
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTLung cancer patients are at risk for brain metastases and often succumb to their intracranial disease. Chimeric Antigen Receptor (CAR) T-cells emerged as a powerful cell-based immunotherapy for hematological malignancies; however, it remains
Externí odkaz:
https://doaj.org/article/2cd0fd06eccb45e2812b5a5b9cb1aecb
Autor:
Hanna F. Nowotny, Thomas Marchant Seiter, Jing Ju, Adrian Gottschlich, Holger Schneider, Stephanie Zopp, Frederick Vogel, Lea Tschaidse, Matthias K. Auer, Christian Lottspeich, Sebastian Kobold, Simon Rothenfusser, Felix Beuschlein, Martin Reincke, Leah Braun, Nicole Reisch
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPatients with primary adrenal insufficiency (PAI) suffer from increased risk of infection, adrenal crises and have a higher mortality rate. Such dismal outcomes have been inferred to immune cell dysregulation because of unphysiological co
Externí odkaz:
https://doaj.org/article/31411e1bff0346db9eb92c284fd78142
Autor:
Natascha Ingrid Drude, Lorena Martinez-Gamboa, Meggie Danziger, Anja Collazo, Silke Kniffert, Janine Wiebach, Gustav Nilsonne, Frank Konietschke, Sophie K. Piper, Samuel Pawel, Charlotte Micheloud, Leonhard Held, Florian Frommlet, Daniel Segelcke, Esther M. Pogatzki-Zahn, Bernhard Voelkl, Tim Friede, Edgar Brunner, Astrid Dempfle, Bernhard Haller, Marie Juliane Jung, Lars Björn Riecken, Hans-Georg Kuhn, Matthias Tenbusch, Lina Maria Serna Higuita, Edmond J. Remarque, Servan Luciano Grüninger-Egli, Katrin Manske, Sebastian Kobold, Marion Rivalan, Lisa Wedekind, Juliane C. Wilcke, Anne-Laure Boulesteix, Marcus W. Meinhardt, Rainer Spanagel, Simone Hettmer, Irene von Lüttichau, Carla Regina, Ulrich Dirnagl, Ulf Toelch
Publikováno v:
Translational Medicine Communications, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Clinical translation from bench to bedside often remains challenging even despite promising preclinical evidence. Among many drivers like biological complexity or poorly understood disease pathology, preclinical evidence often lacks desired
Externí odkaz:
https://doaj.org/article/bf47b97f5e2949fb928a3da8d60cd224
Autor:
Laura Heeb, Betül Taskoparan, Antonios Katsoulas, Michal Beffinger, Pierre- Clavien, Sebastian Kobold, Anurag Gupta, Johannes vom Berg
Publikováno v:
Bio-Protocol, Vol 13, Iss 14 (2023)
The immune-inhibitory molecule programmed cell death ligand 1 (PD-L1) has been shown to play a role in pathologies such as autoimmunity, infections, and cancer. The expression of PD-L1 not only on cancer cells but also on non-transformed host cells i
Externí odkaz:
https://doaj.org/article/c93e4172eacb4444b5477a5df9728293
Autor:
Christian Klein, Daria Briukhovetska, Michael von Bergwelt-Baildon, Sebastian Kobold, Mitchell P Levesque, Bruno L Cadilha, Stefan Endres, Mohamed-Reda Benmebarek, Hannah Obeck, Sophia Stock, Florian Märkl, Julius Keyl, Martina Geiger, Clara Karches, Melanie Schwerdtfeger, Stefanos Michaelides, Jakob Jobst, Philipp Jie Müller, Lina Majed, Matthias Seifert, Anna-Kristina Klüver, Theo Lorenzini, Ruth Grünmeier, Moritz Thomas, Adrian Gottschlich, Richard Klaus, Carsten Marr, Simon Rothenfusser, Markus Vincent Heppt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Melanoma is an immune sensitive disease, as demonstrated by the activity of immune check point blockade (ICB), but many patients will either not respond or relapse. More recently, tumor infiltrating lymphocyte (TIL) therapy has shown promi
Externí odkaz:
https://doaj.org/article/b199e93aa3494d549053b8485d6551d1
Autor:
Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Sven Michel, Frank Jaschinski, Sebastian Kobold, Abhishek S Kashyap, Johannes vom Berg, Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Nicole Kirchhammer, Rainer H Kohler, Elham Jones, Andre Maaske, Karen O Dixon, Mikael J Pittet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Although immune checkpoint inhibitors have been a breakthrough in clinical oncology, these therapies fail to produce durable responses in a significant fraction of patients. This lack of long-term efficacy may be due to a poor pre-existing
Externí odkaz:
https://doaj.org/article/78cf6c8515374d7f847b8913a986bde6
Autor:
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Günes Günsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime García-Añoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Önder Yildirim, Martin Biel, Christian Grimm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the l
Externí odkaz:
https://doaj.org/article/7d029bd581f74fcaa96bcacc1faef5b8
Autor:
Julian Kolorz, Salih Demir, Adrian Gottschlich, Iris Beirith, Matthias Ilmer, Daniel Lüthy, Christoph Walz, Mario M. Dorostkar, Thomas Magg, Fabian Hauck, Dietrich von Schweinitz, Sebastian Kobold, Roland Kappler, Michael Berger
Publikováno v:
Current Oncology, Vol 29, Iss 1, Pp 94-110 (2021)
Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 recep
Externí odkaz:
https://doaj.org/article/b4d76b70588949f19417df65d47f2b16