Tuft Cells and Their Role in Intestinal Diseases

Autor: Sebastian Kjærgaard Hendel, Lauge Kellermann, Annika Hausmann, Niels Bindslev, Kim Bak Jensen, Ole Haagen Nielsen

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune responses and relevance for gut diseases, have increased dramatically over the last fifteen years. A key discovery in 2016 of their close connection to h

Externí odkaz: https://doaj.org/article/5c3219b04c494a48b1ada5d231af0cd9

Nanomolar EP4 receptor potency and expression of eicosanoid-related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia.

Autor: Feddersen, Ulrike Ries¹ (AUTHOR) ulrikerf@hotmail.com, Hendel, Sebastian Kjærgaard¹ (AUTHOR), Berner-Hansen, Mark Alexander¹ (AUTHOR), Jepps, Thomas Andrew² (AUTHOR), Berner-Hansen, Mark¹ (AUTHOR), Bindslev, Niels² (AUTHOR)

Publikováno v: BMC Gastroenterology. Dec2022, Vol. 22 Issue 1, p1-8. 8p.

Decreased number of colonic tuft cells in quiescent ulcerative colitis patients

Autor: Steen Seier Poulsen, Sebastian Kjærgaard, Ulrike Ries Feddersen, Kaare V. Grunddal, Esben Budtz-Jørgensen, Niels Bindslev, Hanne B. Rasmussen, Mark Alexander Berner-Hansen, Thorbjørn Søren Rønn Jensen

Publikováno v: European Journal of Gastroenterology & Hepatology
Kjærgaard, S, Jensen, T S R, Feddersen, U R, Bindslev, N, Grunddal, K V, Poulsen, S S, Rasmussen, H B, Budtz-Jørgensen, E & Berner-Hansen, M 2021, ' Decreased number of colonic tuft cells in quiescent ulcerative colitis patients ', European journal of gastroenterology & hepatology, vol. 33, no. 6, pp. 817-824 . https://doi.org/10.1097/MEG.0000000000001959

BACKGROUND: Colonic tuft cells are epithelial chemosensory cells involved in barrier integrity, modulation of inflammatory responses and gut homeostasis. Recent evidence indicates an involvement of tuft cells in ulcerative colitis pathogenesis, thoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136eb161a40e79e23f88a7443f9e5df8
http://europepmc.org/articles/PMC8083166

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Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?

Autor: Rasmus Hytting-Andreasen, Sebastian Kjærgaard, Morten Matthiesen Bach Damm, Jörg-Dieter Schulzke, Joan Chang, L. Riis, Susanne M. Krug, Hanne B. Rasmussen, Niels Bindslev, Mark Berner Hansen

Publikováno v: Kjærgaard, S, Damm, M M B, Chang, J, Riis, L B, Rasmussen, H B, Hytting-Andreasen, R, Krug, S M, Schulzke, J-D, Bindslev, N & Hansen, M B 2020, ' Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria? ', International Journal of Molecular Sciences . https://doi.org/10.3390/ijms21051887
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1887 (2020)
Kjærgaard, S, Damm, M M B, Chang, J, Riis, L B, Rasmussen, H B, Hytting-Andreasen, R, Krug, S M, Schulzke, J D, Bindslev, N & Berner-Hansen, M 2020, ' Altered structural expression and enzymatic activity parameters in quiescent ulcerative colitis : Are these potential normalization criteria? ', International Journal of Molecular Sciences (Online), vol. 21, no. 5, 1887 . https://doi.org/10.3390/ijms21051887

Mucosal healing determined by endoscopy is currently the remission standard for ulcerative colitis (UC). However, new criteria for remission are emerging, such as histologic normalization, which appears to correlate better to the risk of relapse. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ec5659d808223c28734c6e6cf5f720
https://www.research.manchester.ac.uk/portal/en/publications/altered-structural-expression-and-enzymatic-activity-parameters-in-quiescent-ulcerative-colitis-are-these-potential-normalization-criteria(fb4f418c-9689-42b7-be32-47965c60cff6).html