Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sebastian Kelm"'
Autor:
Igor Jaszczyszyn, Weronika Bielska, Tomasz Gawlowski, Pawel Dudzic, Tadeusz Satława, Jarosław Kończak, Wiktoria Wilman, Bartosz Janusz, Sonia Wróbel, Dawid Chomicz, Jacob D. Galson, Jinwoo Leem, Sebastian Kelm, Konrad Krawczyk
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
AlphaFold2 has hallmarked a generational improvement in protein structure prediction. In particular, advances in antibody structure prediction have provided a highly translatable impact on drug discovery. Though AlphaFold2 laid the groundwork for all
Externí odkaz:
https://doaj.org/article/b9bf830784aa46f6b4415c0e2d6b8f50
Publikováno v:
Journal of Functional Morphology and Kinesiology, Vol 9, Iss 1, p 25 (2024)
The correction of postural weaknesses through the better positioning of the pelvis is an important approach in sports therapy and physiotherapy. The pelvic position in the sagittal plane is largely dependent on the muscular balance of the ventral and
Externí odkaz:
https://doaj.org/article/93db101e014049a2a55427bca5744193
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The propensity for some monoclonal antibodies (mAbs) to aggregate at physiological and manufacturing pH values can prevent their use as therapeutic molecules or delay time to market. Consequently, developability assessments are essential to select op
Externí odkaz:
https://doaj.org/article/ae4bb49c558444769fdeb77ccc96bfe5
Autor:
Bingfa Sun, Dan Feng, Matthew Ling-Hon Chu, Inbar Fish, Silvia Lovera, Zara A. Sands, Sebastian Kelm, Anne Valade, Martyn Wood, Tom Ceska, Tong Sun Kobilka, Florence Lebon, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) an
Externí odkaz:
https://doaj.org/article/2dbb4259799647b08364c62567b2949b
Autor:
Mabel T. Y. Wong, Sebastian Kelm, Xiaofeng Liu, Richard D. Taylor, Terry Baker, Jonathan W. Essex
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/9c003273c04047e885cde25b39cf0c43
Autor:
Mabel T. Y. Wong, Sebastian Kelm, Xiaofeng Liu, Richard D. Taylor, Terry Baker, Jonathan W. Essex
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We have carried out a long-timescale simulation study on crystal structures of nine antibody-antigen pairs, in antigen-bound and antibody-only forms, using molecular dynamics with enhanced sampling and an explicit water model to explore interface con
Externí odkaz:
https://doaj.org/article/9c8442dbe84e4fc28e2f66dd4fdc1822
Autor:
Aleksandr Kovaltsuk, Matthew I J Raybould, Wing Ki Wong, Claire Marks, Sebastian Kelm, James Snowden, Johannes Trück, Charlotte M Deane
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007636 (2020)
Most current analysis tools for antibody next-generation sequencing data work with primary sequence descriptors, leaving accompanying structural information unharnessed. We have used novel rapid methods to structurally characterize the complementary-
Externí odkaz:
https://doaj.org/article/a1a3d6bfc23646c3895acfba9e2ad92f
Autor:
Nicholas M. Pearce, Tobias Krojer, Anthony R. Bradley, Patrick Collins, Radosław P. Nowak, Romain Talon, Brian D. Marsden, Sebastian Kelm, Jiye Shi, Charlotte M. Deane, Frank von Delft
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Building a ligand into a weak region of an electron density map of a protein is a subjective process. Here, the authors present a new method to obtain a clear electron density for a bound ligand based on multi-crystal experiments and 3D background co
Externí odkaz:
https://doaj.org/article/c88bb825cf794f33ac6c39f01dd123b7
Autor:
Konrad Krawczyk, Sebastian Kelm, Aleksandr Kovaltsuk, Jacob D. Galson, Dominic Kelly, Johannes Trück, Cristian Regep, Jinwoo Leem, Wing K. Wong, Jaroslaw Nowak, James Snowden, Michael Wright, Laura Starkie, Anthony Scott-Tucker, Jiye Shi, Charlotte M. Deane
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq). This technique produces large volume sequence snapshots of B-cell receptors that are
Externí odkaz:
https://doaj.org/article/47fb86b0ffff496db413cd8995409a66
Autor:
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2006192 (2018)
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 k
Externí odkaz:
https://doaj.org/article/8aa07cda1edf4eacba469577557c2556