Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sebastian Kallus"'
Autor:
Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Daniela Heilos, Lisa Gabler, Sushilla van Schoonhoven, Alessio Terenzi, Patrick Moser, Christine Pirker, Gerald Timelthaler, Walter Jäger, Christian R. Kowol, Petra Heffeter, Michael Grusch, Walter Berger
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
Abstract Background Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanis
Externí odkaz:
https://doaj.org/article/ab5f3166b8d14e12903480ffb0754129
Autor:
Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Anna Laemmerer, Patrick Moser, Lisa Gabler, Diana Groza, Christian R. Kowol, Petra Heffeter, Michael Grusch, Walter Berger
Publikováno v:
Cells, Vol 7, Iss 12, p 259 (2018)
Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex an
Externí odkaz:
https://doaj.org/article/27749548bad24da2a5f58de1701548d9
Autor:
Christian R. Kowol, Bernhard Englinger, Dina Baier, Johannes Gojo, Anna Laemmerer, Laura Niederstaetter, Walter Berger, Thomas Mohr, Clemens Röhrl, Gerald Timelthaler, Walter Jäger, Patrick Moser, Christine Pirker, Samuel M. Meier-Menches, Lisa Gabler, Petra Heffeter, Julia Senkiv, Sebastian Kallus, Christopher Gerner
Publikováno v:
International Journal of Cancer
Ponatinib is a small molecule multi‐tyrosine kinase inhibitor clinically approved for anticancer therapy. Molecular mechanisms by which cancer cells develop resistance against ponatinib are currently poorly understood. Likewise, intracellular drug
Autor:
Éva A. Enyedy, Lukas Uhlik, Christian R. Kowol, Thilo Hofmann, Sebastian Kallus, Walter Berger, Petra Heffeter, Sushilla van Schoonhoven, Karla Pelivan, Bernhard K. Keppler
Publikováno v:
Journal of Inorganic Biochemistry. 190:85-97
Triapine, the most prominent anticancer drug candidate from the substance class of thiosemicarbazones, was investigated in >30 clinical phase I and II studies. However, the results were rather disappointing against solid tumors, which can be explaine
Autor:
Christian Freudlsperger, Urs Eisenmann, Jürgen Hoffmann, Moritz Berger, Robin Seeberger, Hartmut Dickhaus, Michael Engel, Sebastian Kallus, Oliver Ristow, Igor Nova
Publikováno v:
Journal of Cranio-Maxillofacial Surgery. 45:1593-1599
Introduction Because of the inaccuracy of intermaxillary splints in orthognathic surgery, intraoperative guidance via a real time navigation system might represent a suitable method for enhancing the precision of maxillary positioning. Therefore, in
Autor:
Sebastian Kallus, Christian Freudlsperger, Urs Eisenmann, Moritz Berger, Hartmut Dickhaus, Oliver Ristow, Jürgen Hoffmann, Robin Seeberger, Igor Nova
Publikováno v:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123:298-304
Objectives Inaccuracies in orthognathic surgery can be caused during face-bow registration, model surgery on plaster models, and intermaxillary splint manufacturing. Electromagnetic (EM) navigation is a promising method for splintless digitized maxil
Publikováno v:
Current Directions in Biomedical Engineering, Vol 2, Iss 1, Pp 363-367 (2016)
Severe gait abnormalities in patients with cerebral palsy are often treated by correction osteotomy. The established procedure of femoral derotation osteotomy (FDO) has proven effective to realign femur anteversion. Nevertheless, studies have reveale
Autor:
Bernhard Englinger, Bernhard K. Keppler, Petra Heffeter, Julia Senkiv, Sebastian Kallus, Christian R. Kowol, Walter Berger, Anna Laemmerer
Publikováno v:
Nanomedicine
Fibroblast growth factor receptor (FGFR) inhibitors like ponatinib and nintedanib are clinically approved for defined cancer patient cohorts but often exert dose-limiting adverse effects. Hence, we encapsulated the FGFR inhibitors ponatinib, PD173074
Autor:
Jürgen Hoffmann, Moritz Berger, Hartmut Dickhaus, Igor Nova, Urs Eisenmann, Sebastian Kallus, Christian Freudlsperger, Oliver Ristow
Publikováno v:
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 45(5)
Introduction Modifications of the temporomandibular joint position after mandible osteotomy are reluctantly accepted in orthognathic surgery. To tackle this problem, we developed a new navigation system using miniaturized electromagnetic sensors. Our
Autor:
Walter Berger, Bernhard K. Keppler, Kushtrim Kryeziu, Britta Fischer, Petra Heffeter, Christian R. Kowol, Sebastian Kallus
Triapine is a promising anticancer thiosemicarbazone which was investigated in multiple clinical trials, where it was active against leukemia but not against solid cancers. This is probably based on insufficient drug levels in the tumor due to a shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e0f2877c44ad1612855c0cc30dbff6
https://doi.org/10.1039/c6ra07659a
https://doi.org/10.1039/c6ra07659a