Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sebastian Jespersen Charlton"'
Autor:
Jan Fabio Nickels, Maria Eduarda Della-Rosa, Iñigo Miguelez Goyeneche, Sebastian Jespersen Charlton, Kim Sneppen, Genevieve Thon
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110828- (2022)
Summary: Transcription factors can exert opposite effects depending on the chromosomal context. The fission yeast transcription factor Atf1 both activates numerous genes in response to stresses and mediates heterochromatic gene silencing in the matin
Externí odkaz:
https://doaj.org/article/83af020f44bd438d961a62ac8d8fa949
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Charlton, S J, Jørgensen, M M & Thon, G 2020, ' Integrity of a heterochromatic domain ensured by its boundary elements ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 35, pp. 21504-21511 . https://doi.org/10.1073/pnas.2010062117
Charlton, S J, Jørgensen, M M & Thon, G 2020, ' Integrity of a heterochromatic domain ensured by its boundary elements ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 35, pp. 21504-21511 . https://doi.org/10.1073/pnas.2010062117
Significance The fission yeast silent mating-type region provides an excellent system to ask how chromatic domains with opposite effects on gene expression coexist side by side along chromosomes and to investigate roles played by DNA elements and arc
Autor:
Sif Christine Lykke Hougaard, Geneviève Thon, Jan Fabio Nickels, Ala Trusina, Amanda Møller Mortensen, Kim Sneppen, Sebastian Jespersen Charlton, Ashleigh Katrine Edwards
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Nickels, J F, Edwards, A K, Charlton, S J, Mortensen, A M, Hougaard, S C L, Trusina, A, Sneppen, K & Thon, G 2021, ' Establishment of heterochromatin in domain-size-dependent bursts ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 15, e2022887118 . https://doi.org/10.1073/pnas.2022887118
Proceedings of the National Academy of Sciences
Nickels, J F, Edwards, A K, Charlton, S J, Mortensen, A M, Hougaard, S C L, Trusina, A, Sneppen, K & Thon, G 2021, ' Establishment of heterochromatin in domain-size-dependent bursts ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 15, e2022887118 . https://doi.org/10.1073/pnas.2022887118
Significance How repressive heterochromatic states propagate along chromosomes and are subsequently maintained for many cell divisions remain important unanswered questions in biology. Combining mathematical modeling and single-cell measurements, we