Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Sebastian J. Streichan"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
How does DNA encode shape? Here, via in toto light sheet microscopy and optogenetic control of cellular forces, the authors show that spatially patterned mechanical feedback loops establish the cytoskeletal patterns driving axis elongation tissue flo
Externí odkaz:
https://doaj.org/article/95c6771c45d545038a417f9466ece5b5
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The extracellular matrix can shape developing organs, but how external forces direct intercellular morphogenesis is unclear. Here, the authors use 3D imaging to show that elongation of the Drosophila egg chamber involves polarized cell reorientation
Externí odkaz:
https://doaj.org/article/e771acac7c584a05a3c17ffd57e94efa
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Neural crest cells arise within the central nervous system, then migrate and contribute to a variety of cell types. Here, the authors use multiplex transcript analysis at single cell resolution to define neural crest and neural subpopulations within
Externí odkaz:
https://doaj.org/article/20ff53cbeb6f4c4cb688d6afb9c826e3
Publikováno v:
Cell Reports, Vol 15, Iss 6, Pp 1125-1133 (2016)
Planar cell polarity (PCP) information is a critical determinant of organ morphogenesis. While PCP in bounded epithelial sheets is increasingly well understood, how PCP is organized in tubular and acinar tissues is not. Drosophila egg chambers (folli
Externí odkaz:
https://doaj.org/article/d32e1f27cd6b4b2abe34c90b1b9c078f
Publikováno v:
Physical Review X, Vol 10, Iss 1, p 011072 (2020)
Cellular mechanics drives epithelial morphogenesis, the process wherein cells collectively rearrange to produce tissue-scale deformations that determine organismal shape. However, quantitative understanding of tissue mechanics is impaired by the diff
Externí odkaz:
https://doaj.org/article/d5d5d3216ced40f186fa87ddb57e5a6c
Autor:
Noah P Mitchell, Dillon J Cislo, Suraj Shankar, Yuzheng Lin, Boris I Shraiman, Sebastian J Streichan
Publikováno v:
eLife, Vol 11 (2022)
Organ architecture is often composed of multiple laminar tissues arranged in concentric layers. During morphogenesis, the initial geometry of visceral organs undergoes a sequence of folding, adopting a complex shape that is vital for function. Geneti
Externí odkaz:
https://doaj.org/article/f09c7a41efc14ef283cc4d865938d3b1
Autor:
Dillon J. Cislo, Fengshuo Yang, Haodong Qin, Anastasios Pavlopoulos, Mark J. Bowick, Sebastian J. Streichan
Publikováno v:
Nature Physics.
Morphogenesis, the process through which genes generate form, establishes tissue-scale order as a template for constructing the complex shapes of the body plan. The extensive growth required to build these ordered substrates is fuelled by cell prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c319fc396d5b26cdbfcfff21cfea4618
https://doi.org/10.1038/s41567-023-02025-3
https://doi.org/10.1038/s41567-023-02025-3
Autor:
Nikolas H Claussen, Matthew F Lefebvre, Noah P Mitchell, Hannah J Gustafson, Sebastian J Streichan
The actomyosin cytoskeleton is a crucial driver of morphogenesis. Yet how the behavior of large-scale cytoskeletal patterns in deforming tissues emerges from the interplay of geometry, genetics, and mechanics remains incompletely understood. Converge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabe95adc2d9d8a18b00bbd2153543b3
https://escholarship.org/uc/item/36f9f64p
https://escholarship.org/uc/item/36f9f64p
Publikováno v:
eLife, Vol 7 (2018)
During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding into specific shapes. While developmental biology has identified key genes and local cellular processes, global coordination of tissue remodeling at the organ scale
Externí odkaz:
https://doaj.org/article/808e6457005543f7bf13854d34731e01
Autor:
Heitor C. Megale, George Britton, Kenneth S. Kosik, Aryeh Warmflash, Aimal H. Khankhel, Eyal Karzbrun, Eric D. Siggia, Sebastian J. Streichan, Stella M. K. Glasauer, Yofiel Wyle, Boris I. Shraiman
Publikováno v:
Nature. 599:268-272
Understanding human organ formation is a scientific challenge with far-reaching medical implications1,2. Three-dimensional stem-cell cultures have provided insights into human cell differentiation3,4. However, current approaches use scaffold-free ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3095db8b29b0bcd082e9709224830f61
https://doi.org/10.1038/s41586-021-04026-9
https://doi.org/10.1038/s41586-021-04026-9