Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sebastian J Theobald"'
Autor:
Sebastian J Theobald, Alexander Simonis, Julie M Mudler, Ulrike Göbel, Richard Acton, Viktoria Kohlhas, Marie‐Christine Albert, Anna‐Maria Hellmann, Jakob J Malin, Sandra Winter, Michael Hallek, Henning Walczak, Phuong‐Hien Nguyen, Manuel Koch, Jan Rybniker
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 8, Pp 1-15 (2022)
Abstract Durable cell‐mediated immune responses require efficient innate immune signaling and the release of pro‐inflammatory cytokines. How precisely mRNA vaccines trigger innate immune cells for shaping antigen specific adaptive immunity remain
Externí odkaz:
https://doaj.org/article/7926e223485940a9aef27db746442b81
Autor:
Sebastian J Theobald, Alexander Simonis, Theodoros Georgomanolis, Christoph Kreer, Matthias Zehner, Hannah S Eisfeld, Marie‐Christine Albert, Jason Chhen, Susanne Motameny, Florian Erger, Julia Fischer, Jakob J Malin, Jessica Gräb, Sandra Winter, Andromachi Pouikli, Friederike David, Boris Böll, Philipp Koehler, Kanika Vanshylla, Henning Gruell, Isabelle Suárez, Michael Hallek, Gerd Fätkenheuer, Norma Jung, Oliver A Cornely, Clara Lehmann, Peter Tessarz, Janine Altmüller, Peter Nürnberg, Hamid Kashkar, Florian Klein, Manuel Koch, Jan Rybniker
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-20 (2021)
Abstract Innate immunity triggers responsible for viral control or hyperinflammation in COVID‐19 are largely unknown. Here we show that the SARS‐CoV‐2 spike protein (S‐protein) primes inflammasome formation and release of mature interleukin
Externí odkaz:
https://doaj.org/article/2445731f5efd43e7bf9dcd749ffcad99
Autor:
Sebastian J Theobald, Jan Rybniker
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-2 (2022)
Abstract Cells of the innate immune system represent the first line of defense against SARS‐CoV‐2 and play an essential role in activating adaptive immunity, which mediates long‐term protection. In addition, the same cells are key drivers of ti
Externí odkaz:
https://doaj.org/article/3f16e54c816544cfbbc0b2235bcb1571
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract The ongoing SARS‐CoV‐2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By repurposing of broadly active antiviral drugs and com
Externí odkaz:
https://doaj.org/article/350ac924a79b4e16a9a43340f086ed61
Autor:
Sebastian J Theobald, Christoph Kreer, Sahamoddin Khailaie, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Michael Mach, Marija Backovic, Matthias Ballmaier, Johannes Koenig, Henning Olbrich, Andreas Schneider, Valery Volk, Simon Danisch, Lutz Gieselmann, Meryem Seda Ercanoglu, Martin Messerle, Constantin von Kaisenberg, Torsten Witte, Frank Klawonn, Michael Meyer-Hermann, Florian Klein, Renata Stripecke
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009385 (2021)
[This corrects the article DOI: 10.1371/journal.ppat.1008560.].
Externí odkaz:
https://doaj.org/article/72bbc76a422042ae8b6a3c595f061581
Autor:
Sebastian J Theobald, Christoph Kreer, Sahamoddin Khailaie, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Michael Mach, Marija Backovic, Matthias Ballmaier, Johannes Koenig, Henning Olbrich, Andreas Schneider, Valery Volk, Simon Danisch, Lutz Gieselmann, Meryem Seda Ercanoglu, Martin Messerle, Constantin von Kaisenberg, Torsten Witte, Frank Klawonn, Michael Meyer-Hermann, Florian Klein, Renata Stripecke
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008560 (2020)
Human cytomegalovirus (HCMV) causes serious complications to immune compromised hosts. Dendritic cells (iDCgB) expressing granulocyte-macrophage colony-stimulating factor, interferon-alpha and HCMV-gB were developed to promote de novo antiviral adapt
Externí odkaz:
https://doaj.org/article/c1d9d22801744c638a64acbe75f4086c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mycobacterium tuberculosis (Mtb) infection represents a global health problem and is characterized by formation of granuloma with a necrotic center and a systemic inflammatory response. Inflammasomes have a crucial role in the host immune response to
Externí odkaz:
https://doaj.org/article/2a359759e477494d8d8e538cde9db323
Autor:
Julia D. Knopf, Susanne S. Steigleder, Friederike Korn, Nathalie Kühnle, Marina Badenes, Marina Tauber, Sebastian J. Theobald, Jan Rybniker, Colin Adrain, Marius K. Lemberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The toll-like receptor 4 (TLR4) is a central regulator of innate immunity that primarily recognizes bacterial lipopolysaccharide cell wall constituents to trigger cytokine secretion. We identify the intramembrane protease RHBDL4 as a negativ
Externí odkaz:
https://doaj.org/article/2af17f35039c4574bcf982ab43936405
Autor:
Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans A. Schlößer, Kerstin Wennhold, Martin Thelen, Maria A. Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, Masudur Rahman, Jan-Malte Kleid, Sebastian J. Theobald, Eugen Bauer, Constantin von Kaisenberg, Steven R. Talbot, Leonard D. Shultz, Brian Soper, Renata Stripecke
Publikováno v:
Cells, Vol 13, Iss 20, p 1686 (2024)
Background: Humanized mice transplanted with CD34+ hematopoietic cells (HPCs) are broadly used to study human immune responses and infections in vivo and for testing therapies pre-clinically. However, until now, it was not clear whether interactions
Externí odkaz:
https://doaj.org/article/633b76dd515d43d3b3abd9316c52d10a
Autor:
Sebastian J. Theobald, Elena Fiestas, Andreas Schneider, Benjamin Ostermann, Simon Danisch, Constantin von Kaisenberg, Jan Rybniker, Wolfgang Hammerschmidt, Reinhard Zeidler, Renata Stripecke
Publikováno v:
Cells, Vol 13, Iss 1, p 20 (2023)
Antiviral neutralizing antibodies (nAbs) are commonly derived from B cells developed in immunized or infected animals and humans. Fully human antibodies are preferred for clinical use as they are potentially less immunogenic. However, the function of
Externí odkaz:
https://doaj.org/article/fbf2eb71ec7849e58367a95268336eee