Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sebastian J, Theobald"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mycobacterium tuberculosis (Mtb) infection represents a global health problem and is characterized by formation of granuloma with a necrotic center and a systemic inflammatory response. Inflammasomes have a crucial role in the host immune response to
Externí odkaz:
https://doaj.org/article/2a359759e477494d8d8e538cde9db323
Autor:
Julia D. Knopf, Susanne S. Steigleder, Friederike Korn, Nathalie Kühnle, Marina Badenes, Marina Tauber, Sebastian J. Theobald, Jan Rybniker, Colin Adrain, Marius K. Lemberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The toll-like receptor 4 (TLR4) is a central regulator of innate immunity that primarily recognizes bacterial lipopolysaccharide cell wall constituents to trigger cytokine secretion. We identify the intramembrane protease RHBDL4 as a negativ
Externí odkaz:
https://doaj.org/article/2af17f35039c4574bcf982ab43936405
Autor:
Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans A. Schlößer, Kerstin Wennhold, Martin Thelen, Maria A. Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, Masudur Rahman, Jan-Malte Kleid, Sebastian J. Theobald, Eugen Bauer, Constantin von Kaisenberg, Steven R. Talbot, Leonard D. Shultz, Brian Soper, Renata Stripecke
Publikováno v:
Cells, Vol 13, Iss 20, p 1686 (2024)
Background: Humanized mice transplanted with CD34+ hematopoietic cells (HPCs) are broadly used to study human immune responses and infections in vivo and for testing therapies pre-clinically. However, until now, it was not clear whether interactions
Externí odkaz:
https://doaj.org/article/633b76dd515d43d3b3abd9316c52d10a
Autor:
Sebastian J Theobald, Alexander Simonis, Julie M Mudler, Ulrike Göbel, Richard Acton, Viktoria Kohlhas, Marie‐Christine Albert, Anna‐Maria Hellmann, Jakob J Malin, Sandra Winter, Michael Hallek, Henning Walczak, Phuong‐Hien Nguyen, Manuel Koch, Jan Rybniker
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 8, Pp 1-15 (2022)
Abstract Durable cell‐mediated immune responses require efficient innate immune signaling and the release of pro‐inflammatory cytokines. How precisely mRNA vaccines trigger innate immune cells for shaping antigen specific adaptive immunity remain
Externí odkaz:
https://doaj.org/article/7926e223485940a9aef27db746442b81
Autor:
Sebastian J. Theobald, Elena Fiestas, Andreas Schneider, Benjamin Ostermann, Simon Danisch, Constantin von Kaisenberg, Jan Rybniker, Wolfgang Hammerschmidt, Reinhard Zeidler, Renata Stripecke
Publikováno v:
Cells, Vol 13, Iss 1, p 20 (2023)
Antiviral neutralizing antibodies (nAbs) are commonly derived from B cells developed in immunized or infected animals and humans. Fully human antibodies are preferred for clinical use as they are potentially less immunogenic. However, the function of
Externí odkaz:
https://doaj.org/article/fbf2eb71ec7849e58367a95268336eee
Autor:
Max Augustin, Ferdinand Heyn, Stella Ullrich, Ute Sandaradura de Silva, Marie-Christine Albert, Viktoria Linne, Maike Schlotz, Philipp Schommers, Elisabeth Pracht, Carola Horn, Isabelle Suarez, Alexander Simonis, Lea Katharina Picard, Alexander Zoufaly, Christoph Wenisch, Gerd Fätkenheuer, Henning Gruell, Florian Klein, Michael Hallek, Henning Walczak, Jan Rybniker, Sebastian J. Theobald, Clara Lehmann
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundSymptoms lasting longer than 12 weeks after severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection are called post-coronavirus disease (COVID) syndrome (PCS). The identification of new biomarkers that predict the occurr
Externí odkaz:
https://doaj.org/article/8cfddbe633b846a390c185607e2ac33d
Autor:
Sebastian J. Theobald, Jessica Gräb, Melanie Fritsch, Isabelle Suárez, Hannah S. Eisfeld, Sandra Winter, Maximilian Koch, Christoph Hölscher, Manolis Pasparakis, Hamid Kashkar, Jan Rybniker
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis (Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but how these are interconnected and linked to the rel
Externí odkaz:
https://doaj.org/article/0c22479060434ec2ab2a8edcce1329f5
Autor:
Julia K. Bialek-Waldmann, Sabine Domning, Ruth Esser, Wolfgang Glienke, Mira Mertens, Krasimira Aleksandrova, Lubomir Arseniev, Suresh Kumar, Andreas Schneider, Johannes Koenig, Sebastian J. Theobald, Hsin-Chieh Tsay, Angela D.A. Cornelius, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Dirk Schaudien, Steven R. Talbot, Andre Bleich, Loukia M. Spineli, Constantin von Kaisenberg, Caren Clark, Rainer Blasczyk, Michael Heuser, Arnold Ganser, Ulrike Köhl, Farzin Farzaneh, Renata Stripecke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 621-641 (2021)
Acute myeloid leukemia (AML) patients with minimal residual disease and receiving allogeneic hematopoietic stem cell transplantation (HCT) have poor survival. Adoptive administration of dendritic cells (DCs) presenting the Wilms tumor protein 1 (WT1)
Externí odkaz:
https://doaj.org/article/aa4cf9a177124c648d5410e058e734cf
Autor:
Sebastian J Theobald, Alexander Simonis, Theodoros Georgomanolis, Christoph Kreer, Matthias Zehner, Hannah S Eisfeld, Marie‐Christine Albert, Jason Chhen, Susanne Motameny, Florian Erger, Julia Fischer, Jakob J Malin, Jessica Gräb, Sandra Winter, Andromachi Pouikli, Friederike David, Boris Böll, Philipp Koehler, Kanika Vanshylla, Henning Gruell, Isabelle Suárez, Michael Hallek, Gerd Fätkenheuer, Norma Jung, Oliver A Cornely, Clara Lehmann, Peter Tessarz, Janine Altmüller, Peter Nürnberg, Hamid Kashkar, Florian Klein, Manuel Koch, Jan Rybniker
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-20 (2021)
Abstract Innate immunity triggers responsible for viral control or hyperinflammation in COVID‐19 are largely unknown. Here we show that the SARS‐CoV‐2 spike protein (S‐protein) primes inflammasome formation and release of mature interleukin
Externí odkaz:
https://doaj.org/article/2445731f5efd43e7bf9dcd749ffcad99
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract The ongoing SARS‐CoV‐2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By repurposing of broadly active antiviral drugs and com
Externí odkaz:
https://doaj.org/article/350ac924a79b4e16a9a43340f086ed61