Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sebastian Honnen"'
Autor:
Fabian Rose, Beate Köberle, Sebastian Honnen, Cindy Bay, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Dirk Theile
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116450- (2024)
Cisplatin not only targets DNA but also RNA. However, it is largely unknown whether platinated RNA (Pt-RNA) causes apoptosis and thus contributes to the cytotoxic effects of cisplatin. Consequently, cellular RNA was isolated from HepG2 and LS180 cell
Externí odkaz:
https://doaj.org/article/691ee0e015794113952a9066ccf52ae9
Autor:
Carmen Martínez-Fernández, Milana Bergamino, Alfonso Schiavi, David Brena, Natascia Ventura, Sebastian Honnen, Alberto Villanueva, Ernest Nadal, Julián Cerón
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used the nematode Caenorhabditis elegans to identify genetic factors influencing the sensitivity and resistance to cisplatin. In this stu
Externí odkaz:
https://doaj.org/article/cdcb1c8b76c94909a5a92b8767d40b32
Autor:
Francisco Javier García-Rodríguez, Carmen Martínez-Fernández, David Brena, Dmytro Kukhtar, Xènia Serrat, Ernest Nadal, Mike Boxem, Sebastian Honnen, Antonio Miranda-Vizuete, Alberto Villanueva, Julián Cerón
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties, namely the onset of resistance to the
Externí odkaz:
https://doaj.org/article/51ccd73708654c859b50b6fa34bb2138
Autor:
Vanessa Brinkmann, Anna Wellenberg, Sebastian Honnen, Julia Bornhorst, Natascia Ventura, Gerhard Fritz
Publikováno v:
Pharmacological Research. 174:105921
Neurotoxicity is a frequent side effect of cisplatin (CisPt)-based anticancer therapy whose pathophysiology is largely vague. Here, we exploited C. elegans as a 3R-compliant in vivo model to elucidate molecular mechanisms contributing to CisPt-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c5aff1aecd16a658a3d7f79ca8e025
https://doi.org/10.1016/j.phrs.2021.105921
https://doi.org/10.1016/j.phrs.2021.105921
Autor:
Anna Wellenberg, Lea Weides, Gerhard Fritz, Jennifer Kurzke, Vanessa Brinkmann, Sebastian Honnen, Till Hennecke, Uwe Karst, Julia Bornhorst, Barbara Crone
Publikováno v:
Experimental Neurology. 341:113705
Anticancer therapeutics can provoke severe side effects that impair the patient's quality of life. A frequent dose-limiting side effect of platinum-based anticancer therapy is neurotoxicity. Its pathophysiology is poorly understood, and effective pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60be21009911c959c071d7751035f52
https://doi.org/10.1016/j.expneurol.2021.113705
https://doi.org/10.1016/j.expneurol.2021.113705
Autor:
Sebastian Honnen
Publikováno v:
Archives of Toxicology. 91:2029-2044
In view of increased life expectancy the risk for disturbed integrity of genetic information increases. This inevitably holds the implication for higher incidence of age-related diseases leading to considerable cost increase in health care systems. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f863237293082e2afc73bfa1ebe42c
https://doi.org/10.1007/s00204-017-1944-7
https://doi.org/10.1007/s00204-017-1944-7
Publikováno v:
Aging and Disease
Statins belong to the most pre-scribed cholesterol lowering drugs in western countries. Their competitive inhibition of the HMG-CoA reductase causes a reduction in the mevalonate pool, resulting in reduced cholesterol biosynthesis, impaired protein p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2f022a1b82d6b0b6c716183d14e53f
https://doi.org/10.14336/ad.2019.0416
https://doi.org/10.14336/ad.2019.0416
Autor:
Thomas E. Johnson, Sebastian Honnen, Henok Kassahun, Björn Schumacher, Natascia Ventura, Anjumara Shaik, Silvia Maglioni, Shane L. Rea, Alfonso Schiavi, Hans Christian Reinhardt, Hilde Nilsen, Alessandro Torgovnick
Publikováno v:
EMBO reports. 19
Interventions that promote healthy aging are typically associated with increased stress resistance. Paradoxically, reducing the activity of core biological processes such as mitochondrial or insulin metabolism promotes the expression of adaptive resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17db3ae2712c4d99d1d0f68f2b61a746
https://doi.org/10.15252/embr.201845856
https://doi.org/10.15252/embr.201845856
Autor:
Mike Boxem, Dmytro Kukhtar, Julián Cerón, Antonio Miranda-Vizuete, Carmen Martínez-Fernández, Alberto Villanueva, Ernest Nadal, Francisco J. García-Rodríguez, Xènia Serrat, Sebastian Honnen, David Brena
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties, namely the onset of resistance to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447873359fc65d1dfeedb2f4366ac15d
http://hdl.handle.net/2445/172420
http://hdl.handle.net/2445/172420
Autor:
Katharina Geist, Lena Schumacher, Sebastian Honnen, Björn Stork, Sebastian Wesselborg, Fabian Stuhldreier, Katharina Krüger, Nicolaj Klöcker, Stefanie Bormann, Gerhard Fritz, Wynand P. Roos, Lena Blümel, Marc Remke
Publikováno v:
Cancer letters. 430
Targeting of oncogene-driven replicative stress as therapeutic option for high-risk medullobastoma was assessed using a panel of medulloblastoma cells differing in their c-Myc expression [i.e. group SHH (c-Myc low) vs. group 3 (c-Myc high)]. High c-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122873589a5ddf9431a26118c6c26843
https://pubmed.ncbi.nlm.nih.gov/29753759
https://pubmed.ncbi.nlm.nih.gov/29753759