Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Sebastian Heikaus"'
Autor:
Natalie Herold, Johanna Schmolling, Corinna Ernst, Beyhan Ataseven, Britta Blümcke, Birgid Schömig‐Markiefka, Sebastian Heikaus, Uwe‐Jochen Göhring, Christoph Engel, Björn Lampe, Kerstin Rhiem, Philipp Harter, Jan Hauke, Rita K. Schmutzler, Eric Hahnen
Publikováno v:
Cancer Medicine, Vol 12, Iss 14, Pp 15256-15260 (2023)
To assess the role of germline pathogenic variants (PVs) in SMARCA4 and further established ovarian cancer (OC) predisposition genes in early onset OC, we investigated a clinical cohort of 206 unrelated OC index patients with an age at diagnosis of O
Externí odkaz:
https://doaj.org/article/a4dab6cdb70a41468a57a4e15e0a1712
Autor:
Florian Heitz, Beyhan Ataseven, Claudia Staniczok, Carsten Denkert, Kerstin Rhiem, Eric Hahnen, Sebastian Heikaus, Malak Moubarak, Julia Welz, Timoleon Dagres, Vasilios Vrentas, Mareike Bommert, Stephanie Schneider, Nicole Concin, Philipp Harter
Publikováno v:
Cancers, Vol 15, Iss 3, p 818 (2023)
The chemotherapy backbone for patients with high-grade advanced epithelial ovarian cancer (HG-AOC) is carboplatin and paclitaxel followed by a maintenance therapy either with bevacizumab, with a PARP inhibitor, or with a combination of both, which is
Externí odkaz:
https://doaj.org/article/f6c4d16fac17483bbedcd32331bd872d
Autor:
Florian Heitz, Sotirios Lakis, Philipp Harter, Sebastian Heikaus, Jalid Sehouli, Jatin Talwar, Roopika Menon, Beyhan Ataseven, Miriam Bertrand, Stephanie Schneider, Erika Mariotti, Mareike Bommert, Judith N Müller, Sonia Prader, Frauke Leenders, Alexandra Hengsbach, Christian Gloeckner, Elena Ioana Braicu, Lukas C Heukamp, Andreas du Bois, Johannes M Heuckmann
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0262770 (2022)
BackgroundThe present prospective study aimed at determining the impact of cell-free tumor DNA (ct-DNA), CA125 and HE4 from blood and ascites for quantification of tumor burden in patients with advanced high-grade serous epithelial ovarian cancer (EO
Externí odkaz:
https://doaj.org/article/e2bb896377e24b0ba18e2a7ddeeda5de
Autor:
Elena Ioana Braicu, Andreas du Bois, Jalid Sehouli, Julia Beck, Sonia Prader, Hagen Kulbe, Bernd Eiben, Philipp Harter, Alexander Traut, Klaus Pietzner, Ralf Glaubitz, Beyhan Ataseven, Radoslav Chekerov, Christoph Keck, Thomas Winkler, Sebastian Heikaus, Peggy Gellendin, Ekkehard Schütz, Florian Heitz
Publikováno v:
Cancers, Vol 14, Iss 1, p 168 (2021)
Background: Chromosomal instability, a hallmark of cancer, results in changes in the copy number state. These deviant copy number states can be detected in the cell-free DNA (cfDNA) and provide a quantitative measure of the ctDNA levels by converting
Externí odkaz:
https://doaj.org/article/a1aad3f89dfd43378fe80cdacab867a5
Autor:
Helmut Plett, MD, Enzo Ricciardi, MD, PhD, Philipp Harter, MD, PhD, Beyhan Ataseven, MD, PhD, Florian Heitz, MD, Sonia Prader, MD, Stephanie Schneider, MD, Sebastian Heikaus, MD, PhD, Annette Fisseler-Eckhoff, MD, PhD, Friedrich Kommoss, MD, PhD, Sigurd F. Lax, MD, PhD, Annette Staebler, MD, PhD, Alexander Traut, Andreas du Bois, MD, PhD
Publikováno v:
Data in Brief, Vol 30, Iss , Pp 105653- (2020)
The data presented here is related to the research article entitled “FERTILITY-SPARING SURGERY AND REPRODUCTIVE-OUTCOMES IN PATIENTS WITH BORDERLINE OVARIAN TUMORS” by Plett et al. in Journal of Gynecologic Oncology [1] and is analysed and discus
Externí odkaz:
https://doaj.org/article/287df27b7cf04d7a9a9bac7b479dc386
Autor:
Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher, Sebastian Heikaus
Publikováno v:
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-14 (2017)
Abstract Background Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One important anti-apoptotic fa
Externí odkaz:
https://doaj.org/article/719614e47c2b4761a2747fcd0330dbeb
Publikováno v:
The Thoracic & Cardiovascular Surgeon Reports, Vol 04, Iss 01, Pp 046-048 (2014)
Abstract Deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the articular structures affects predominantly temporomandibular, knee, hip, spine, and wrist joints, and is a rare condition, often mimicking malignancy. Sternoclavicular join
Externí odkaz:
https://doaj.org/article/a9f3150cdc86437e9a366a4a6e3f5321
Autor:
Michael Gliem, Dimitris Panayotopoulos, Peter Feindt, Sebastian Heikaus, Markus C. Fleisch, Rüdiger J. Seitz
Publikováno v:
Case Reports in Neurology, Vol 3, Iss 1, Pp 54-61 (2011)
We report a 66-year-old woman with slowly progressive ataxia due to cerebellar atrophy. Imaging studies revealed multiple lesions in both the lungs and dorsal subpleural space. A biopsy identified the lesions as metastases of a low-grade endometrial
Externí odkaz:
https://doaj.org/article/a2f8b339c1834ad8995c0ec81f64e46b
PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs
Publikováno v:
Cellular Oncology, Vol 32, Iss 1-2, Pp 29-42 (2010)
Background: The importance of caspase-2 activation for mediating apoptosis in cancer is not clear and seems to differ between different tumour types. Furthermore, only few data have been obtained concerning the expression of caspase-2, which can be a
Externí odkaz:
https://doaj.org/article/0e5c1332b20f4a9ea865973ab3126219
Autor:
Sebastian Heikaus, Linda van den Berg, Tobias Kempf, Csaba Mahotka, Helmut Erich Gabbert, Uwe Ramp
Publikováno v:
Cellular Oncology, Vol 30, Iss 5, Pp 419-433 (2008)
Renal cell carcinomas (RCCs) exhibit a marked resistance towards apoptosis. Although most apoptotic stimuli converge at the level of the mitochondria, little is known about the mitochondrial apoptosis pathway in renal cell carcinomas. The aim of the
Externí odkaz:
https://doaj.org/article/4a8d5d0e03bc458fa719a3165b21c867