Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Sebastian Hayes"'
2
Akademický článek
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
Autor: Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol bios
Externí odkaz: https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
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3
Akademický článek
Itaconate confers tolerance to late NLRP3 inflammasome activation
Autor: Monika Bambouskova, Lucie Potuckova, Tomas Paulenda, Martina Kerndl, Denis A. Mogilenko, Kate Lizotte, Amanda Swain, Sebastian Hayes, Ryan D. Sheldon, Hyeryun Kim, Unnati Kapadnis, Abigail E. Ellis, Christine Isaguirre, Samantha Burdess, Anwesha Laha, Gaya K. Amarasinghe, Victor Chubukov, Thomas P. Roddy, Michael S. Diamond, Russell G. Jones, Donald M. Simons, Maxim N. Artyomov
Publikováno v: Cell Reports, Vol 34, Iss 10, Pp 108756- (2021)
Summary: Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activ
Externí odkaz: https://doaj.org/article/dfbaa470a8684ff5a4d62690f4e0c2bb
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4
Akademický článek
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production
Autor: Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B. Sheetz, Kshitiz, Hans R. Aerni, Stefan Gross, Charles Kung, Varman T. Samuel, Gerald I. Shulman, Richard G. Kibbey, Jesse Rinehart
Publikováno v: Cell Reports, Vol 29, Iss 11, Pp 3394-3404.e9 (2019)
Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-f
Externí odkaz: https://doaj.org/article/843a5a89bddc469f9d601bd5b6452f15
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9
Itaconate confers tolerance to late NLRP3 inflammasome activation
Autor: Lucie Potuckova, Christine Isaguirre, Ryan D. Sheldon, Monika Bambouskova, Amanda Swain, Hyeryun Kim, Samantha Burdess, Maxim N. Artyomov, Martina Kerndl, Tomas Paulenda, Anwesha Laha, Abigail E. Ellis, Victor Chubukov, Michael S. Diamond, Sebastian Hayes, Unnati Kapadnis, Russell G. Jones, Kate Lizotte, Gaya K. Amarasinghe, Donald M. Simons, Thomas P. Roddy, Denis A. Mogilenko
Publikováno v: Cell Reports, Vol 34, Iss 10, Pp 108756-(2021)
Summary: Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962db5d46cf52479dac062503bbe2428
http://www.sciencedirect.com/science/article/pii/S2211124721000693
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