Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sebastian Haen"'
Autor:
Nikolaj Frost, Petros Christopoulos, Diego Kauffmann-Guerrero, Jan Stratmann, Richard Riedel, Monica Schaefer, Jürgen Alt, Sylvia Gütz, Daniel C. Christoph, Eckart Laack, Martin Faehling, Richard Fischer, Klaus Fenchel, Sebastian Haen, Lukas Heukamp, Christian Schulz, Frank Griesinger
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Introduction: We report on the results of the German early access program (EAP) with the third-generation ALK- and ROS1-inhibitor lorlatinib. Patients and Methods: Patients with documented treatment failure of all approved ALK/ROS1-specific therapies
Externí odkaz:
https://doaj.org/article/f7e788036eba4a14b4cfaa74838a764b
Autor:
Fiamma Berner, Rebekka Niederer, Jolien J. Luimstra, Oltin Tiberiu Pop, Ann-Kristin Jochum, Mette-Triin Purde, Omar Hasan Ali, David Bomze, Jens Bauer, Lena Katharina Freudenmann, Ana Marcu, Eva-Maria Wolfschmitt, Sebastian Haen, Thorben Gross, Marissa Lisa Dubbelaar, Marie-Therese Abdou, Petra Baumgaertner, Christina Appenzeller, Caroline Cicin-Sain, Tobias Lenz, Daniel E. Speiser, Burkhard Ludewig, Christoph Driessen, Markus Jörger, Martin Früh, Wolfram Jochum, Antonio Cozzio, Hans-Georg Rammensee, Juliane Walz, Jacques Neefjes, Lukas Flatz
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Immune checkpoint inhibitors (ICIs) have improved the survival of patients with non-small cell lung cancer (NSCLC) by reinvigorating tumor-specific T cell responses. However, the specificity of such T cells and the human leukocyte antigen (HLA)-assoc
Externí odkaz:
https://doaj.org/article/0f632727db4e447a8295135e640367b1
Autor:
Nikolaj Frost, Petros Christopoulos, Diego Kauffmann-Guerrero, Jan Stratmann, Richard Riedel, Monica Schaefer, Jürgen Alt, Sylvia Gütz, Daniel C. Christoph, Eckart Laack, Martin Faehling, Richard Fischer, Klaus Fenchel, Sebastian Haen, Lukas Heukamp, Christian Schulz, Frank Griesinger
Publikováno v:
Therapeutic Advances in Medical Oncology
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Introduction: We report on the results of the German early access program (EAP) with the third-generation ALK- and ROS1-inhibitor lorlatinib. Patients and Methods: Patients with documented treatment failure of all approved ALK/ROS1-specific therapies
Autor:
Miriam Baeumers, Kristina Ruhnau, Thomas Breuer, Hendrik Pannen, Bastian Goerlich, Anna Kniebel, Sebastian Haensch, Stefanie Weidtkamp-Peters, Lutz Schmitt, Thomas Klein
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Background A major task of the endosomal sorting complex required for transport (ESCRT) machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of maturing endosomes (MEs), which is essential for the complet
Externí odkaz:
https://doaj.org/article/7647a97da18c48268faae09df2476ff7
Autor:
Alexander Baer, Stephan Schmidt, Sebastian Haensch, Michaela Eder, Georg Mayer, Matthew J. Harrington
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Velvet worms expel a fluid slime that, under shear force, forms stiff fibres that can be dissolved and then regenerated. Here, the authors reveal that the recyclability of these biopolymers relies on mechanoresponsive lipid-protein nanoglobules in th
Externí odkaz:
https://doaj.org/article/fbd672c20d884142820129ea845b2fc3
Autor:
Nicole Berndt, Ekaterina Seib, Soya Kim, Tobias Troost, Marvin Lyga, Jessica Langenbach, Sebastian Haensch, Konstantina Kalodimou, Christos Delidakis, Thomas Klein
Publikováno v:
eLife, Vol 6 (2017)
Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1) and Neuralized (Neur) is required for activation of the DSL ligands Delta (Dl) and Serrate (Ser) to activate Notch signalling. These ligases transfer ubiquitin to lysines of the ligands' intrace
Externí odkaz:
https://doaj.org/article/6c3883d977c54f37b368fed7de5158d6