Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sebastian H. Grimm"'
Autor:
Sebastian H. Grimm, Eelke B. Lenselink, Adriaan W. Tuin, Constant A. A. van Boeckel, Adrianus M. C. H. van den Nieuwendijk, Ruud H. Wijdeven, Jordi F. Keijzer, Mario van der Stelt, Herman S. Overkleeft, Jacques Neefjes, Nora Liu, Gerard J. P. van Westen, Berend Gagestein
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 27(5), 692-699
Bioorganic and Medicinal Chemistry, 27(5), 692-699
Acute myeloid leukemia (AML) is characterized by fast progression and low survival rates, in which Fms-like tyrosine kinase 3 (FLT3) receptor mutations have been identified as a driver mutation in cancer progression in a subgroup of AML patients. Cli
Autor:
Hans den Dulk, Laura Mulder, Lindsey Burggraaff, Thomas Hankemeier, Juan Zhou, Marc P. Baggelaar, Andrea Martella, Bogdan I. Florea, Alexander T Bakker, Mario van der Stelt, Karol Al-Ayed, Chun T. Li, Gerard J. P. van Westen, Herman S. Overkleeft, Vasudev Kantae, Elliot D. Mock, Xinyu Di, Sebastian H. Grimm
Publikováno v:
ACS Chemical Biology, 14(2), 164-169
ACS Chemical Biology
ACS Chemical Biology
Phospholipase A2, group XVI (PLA2G16) is a thiol hydrolase from the HRASLS family that regulates lipolysis in adipose tissue and has been identified as a host factor enabling the cellular entry of picornaviruses. Chemical tools are essential to visua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca19c73d265df10e65e3bb195c5746cb
http://hdl.handle.net/1887/69904
http://hdl.handle.net/1887/69904
Autor:
Giuseppe Campiani, Antonius P A Janssen, Stefania Butini, Daan van der Vliet, Sebastian H. Grimm, Mario van der Stelt, Ming Jiang, Alexander T Bakker
Publikováno v:
ACS Chemical Biology, 13(9), 2406-2413
ACS Chemical Biology
ACS Chemical Biology
Endocannabinoids, an important class of signaling lipids involved in health and disease, are predominantly synthesized and metabolized by enzymes of the serine hydrolase superfamily. Activity-based protein profiling (ABPP) using fluorescent probes, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1b358bcd699473e5e3e01da7422e90
http://hdl.handle.net/11365/1058758
http://hdl.handle.net/11365/1058758
Autor:
Mario van der Stelt, Ruud H. Wijdeven, Sebastian H. Grimm, Eelke B. Lenselink, Gerard J. P. van Westen, Constant A. A. van Boeckel, Jacques Neefjes, Antonius P A Janssen
Publikováno v:
Journal of Chemical Information and Modeling, 59(3), 1221-1229
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling
The interpretation of high-dimensional structure-activity data sets in drug discovery to predict ligand-protein interaction landscapes is a challenging task. Here we present Drug Discovery Maps (DDM), a machine learning model that maps the activity p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcedc0d253974eb16b4a35cae9de6692
http://hdl.handle.net/1887/75291
http://hdl.handle.net/1887/75291