Cytosolic delivery of monobodies using the bacterial type III secretion system inhibits oncogenic BCR: ABL1 signaling

Autor: Chiara Lebon, Sebastian Grossmann, Greg Mann, Florian Lindner, Akiko Koide, Shohei Koide, Andreas Diepold, Oliver Hantschel

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)

Abstract Background The inability of biologics to pass the plasma membrane prevents their development as therapeutics for intracellular targets. To address the lack of methods for cytosolic protein delivery, we used the type III secretion system (T3S

Externí odkaz: https://doaj.org/article/055f4ef3608b4ed18bbc2d25a0454144

A viral genome wide association study and genotypic resistance testing in patients failing first line antiretroviral therapy in the first large countrywide Ethiopian HIV cohort

Autor: Nigus Fikrie Telele, Amare Worku Kalu, Solomon Gebre-Selassie, Daniel Fekade, Gaetano Marrone, Sebastian Grossmann, Ujjwal Neogi, Belete Tegbaru, Anders Sönnerborg

Publikováno v: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)

Abstract Background Antiretroviral therapy (ART) was rolled-out in Ethiopia in 2005, but there are no reports on outcome of ART and human immunodeficiency virus drug resistance (HIVDR) at national level. We described acquired drug resistance mutation

Externí odkaz: https://doaj.org/article/b0587b4c4d184371a73a8239506ae58e

A viral genome wide association study and genotypic resistance testing in patients failing first line antiretroviral therapy in the first large countrywide Ethiopian HIV cohort

Autor: Belete Tegbaru, Gaetano Marrone, Sebastian Grossmann, Solomon Gebre-Selassie, Anders Sönnerborg, Daniel Fekade, Amare Worku Kalu, Ujjwal Neogi, Nigus Fikrie Telele

Publikováno v: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Infectious Diseases

Background Antiretroviral therapy (ART) was rolled-out in Ethiopia in 2005, but there are no reports on outcome of ART and human immunodeficiency virus drug resistance (HIVDR) at national level. We described acquired drug resistance mutations in pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad3fb2bff3d1cf722480eec11b2f7f
http://link.springer.com/article/10.1186/s12879-019-4196-8

Population dynamics of normal human blood inferred from somatic mutations

Autor: Elisa Laurenti, Anthony R. Green, Michael R. Stratton, Nina F. Øbro, Mairi Shepherd, Henry Lee-Six, Sebastian Grossmann, Kevin J. Dawson, Inigo Martincorena, David G. Kent, Robert J. Osborne, Peter J. Campbell, Brian J. P. Huntly, Laura O’Neill, Elizabeth Anderson, Miriam Belmonte

Publikováno v: Nature

Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e59697b90528b553cc0b3747803db9
https://doi.org/10.1038/s41586-018-0497-0

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Autor: David C. Wedge, Michael R. Stratton, Kevin J. Dawson, Sebastian Grossmann, Peter J. Campbell, Jonathan S. Brammeld, Ilias Georgakopoulos-Soares, Young Seok Ju, Sarah O’Meara, Keiran Raine, Calli Latimer, Francesco Iorio, Bee Ling Ng, Burcak Otlu, Kathryn Beal, Jorge Zamora, Adam Butler, Shriram G. Bhosle, Bernardo Rodriguez-Martin, Jennifer Graham, Jon W. Teague, Mark Maddison, Elizabeth Anderson, Nikita Patel, Ludmil B. Alexandrov, Ultan McDermott, Mathew J. Garnett, David Jones, Ching Chiek Koh, Andrew Menzies, Stacey Price, Laura O’Neill, Serena Nik-Zainal, Mia Petljak, Jose M. C. Tubio

Publikováno v: Cell
Petljak, M, Alexandrov, L B, Brammeld, J S, Price, S, Wedge, D C, Grossmann, S, Dawson, K J, Ju, Y S, Iorio, F, Tubio, J M C, Koh, C C, Georgakopoulos-Soares, I, Rodríguez-Martín, B, Otlu, B, O'Meara, S, Butler, A P, Menzies, A, Bhosle, S G, Raine, K, Jones, D R, Teague, J W, Beal, K, Latimer, C, O'Neill, L, Zamora, J, Anderson, E, Patel, N, Maddison, M, Ng, B L, Graham, J, Garnett, M J, McDermott, U, Nik-Zainal, S, Campbell, P J & Stratton, M R 2019, ' Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis ', Cell . https://doi.org/10.1016/j.cell.2019.02.012
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

Summary Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef46c3ac8f2812db476d77816fba4765
https://www.repository.cam.ac.uk/handle/1810/291718