Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sebastian Gb Furness"'
Autor:
Thomas Kruse, Patrick M. Sexton, Trine R. Clausen, Grace Mennen, Tin T. Truong, Denise Wootten, Peter Keov, Peishen Zhao, Sebastian Gb Furness, Madeleine M. Fletcher, Caroline A. Hick
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 377(3)
Obesity and associated comorbidities are a major health burden, and novel therapeutics to help treat obesity are urgently needed. There is increasing evidence that targeting the amylin receptors (AMYRs), heterodimers of the calcitonin G protein-coupl
Autor:
Huynh Th Nguyen, Sebastian Gb Furness, Simon S. Murray, Alexa R Prawdiuk, Rhiannon J. Wood, Jessica L. Fletcher, Junhua Xiao
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) myelination during development and after injury. This is achieved via activation of oligodendrocyte-expressed tropomyosin-related kinase (Trk) B receptor
Autor:
Simon S. Murray, Junhua Xiao, Rhiannon J. Wood, Alexa R Prawdiuk, Sebastian Gb Furness, Huynh Th Nguyen, Jessica L. Fletcher
The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) myelination during development and after injury. This is achieved via activation of oligodendrocyte-expressed tropomyosin-related kinase (Trk) B receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af7ff0aad4d8503e06d5d1efd9dadaf
https://doi.org/10.1101/642918
https://doi.org/10.1101/642918
Autor:
Francis S. Willard, Denise Wootten, Kyle W. Sloop, Krister Bokvist, James Ficorilli, Patrick M. Sexton, Jorge Alsina-Fernandez, Thomas B. Farb, Arthur Christopoulos, Emilia Elizabeth Savage, Aaron D. Showalter, Sebastian Gb Furness
Publikováno v:
Molecular Pharmacology. 82:1066-1073
Identifying novel mechanisms to enhance glucagon-like peptide-1 (GLP-1) receptor signaling may enable nascent medicinal chemistry strategies with the aim of developing new orally available therapeutic agents for the treatment of type 2 diabetes melli
Autor:
Kaleeckal G. Harikumar, Laurence J. Miller, Sebastian Gb Furness, Cassandra Koole, Maoqing Dong, Denise Wootten, Bim Graham, Alicja M. Ball, Arthur Christopoulos, Delia I. Pinon, Patrick M. Sexton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(45)
The glucagon-like peptide-1 receptor (GLP-1R) is a family B G protein-coupled receptor and an important drug target for the treatment of type II diabetes, with activation of pancreatic GLP-1Rs eliciting glucose-dependent insulin secretion. Currently,
Autor:
Alison Hirukawa, Helen Merkens, Erin J Frohwerk, Mindy Lam, Muriel David, Sebastian GB Furness, Michael R Hughes, Kelly M McNagny
Publikováno v:
The Journal of Immunology. 182:94.7-94.7
Endoglycan is a CD34-related sialomucin proposed to play a role in selectin-dependent adhesion of leukocytes to vasculature. Here we have investigated the distribution and function of endoglycan by generating a specific monoclonal antibody to an extr