Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sebastian Essig"'
Autor:
Amanda J Price, David A Jacques, William A McEwan, Adam J Fletcher, Sebastian Essig, Jason W Chin, Upul D Halambage, Christopher Aiken, Leo C James
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004459 (2014)
The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), a
Externí odkaz:
https://doaj.org/article/af6eb117e61e461b8dd82edacf42765a
Autor:
Yves P. Auberson, Paola B. Arimondo, Maria Duca, Sebastian Essig, Uwe Grether, Arne C. Rufer, Gianluca Sbardella, Ulrich Schopfer, Antoni Torrens, Mario van der Stelt, Boris Vauzeilles, Olalla Vázquez, Andrew X. Zhang
Publikováno v:
ChemBioChem. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d8dd6f2ea73f60739279de36705d85f
https://doi.org/10.1002/cbic.202200690
https://doi.org/10.1002/cbic.202200690
Autor:
Lukas M. Wingen, Martina Adamek, Max Schönenbroicher, Dirk Menche, Sebastian Essig, Maximilian Seul, Michael Kurz, Nadine Ziemert, Stefanie Spindler
Publikováno v:
Organic Letters. 23:1175-1180
Elaborate fragments of the proposed stereostructure of the complex polyketide antibiotic vancoresmycin have been synthesized in a stereoselective fashion based on a modular and convergent approach. Significant nuclear magnetic resonance differences i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab1d1419199cf0115dffc70d657e26c
https://doi.org/10.1021/acs.orglett.0c03957
https://doi.org/10.1021/acs.orglett.0c03957
Publikováno v:
Organic letters. 22(16)
The total synthesis of the potent respiratory chain inhibitor ajudazol A was accomplished by a concise strategy in 17 steps (longest linear sequence). The modular approach was based on a direct oxazole functionalization strategy involving a halogen d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f654744c540e8cce15d0060e230b77
https://pubmed.ncbi.nlm.nih.gov/32806171
https://pubmed.ncbi.nlm.nih.gov/32806171
Autor:
Sebastian Thiede, Peter Winterscheid, Gregor Schnakenburg, Dirk Menche, Sebastian Essig, Jan Hartmann
Publikováno v:
Synthesis. 48:697-709
An efficient synthetic strategy to access hydroxyl-isochromanone and -isobenzofurans from readily available joint alkene precursors by a regiodivergent one-pot iodocyclization–substitution tandem process is reported. The cyclizations proceed with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c17cd31c1a07f7b60b0593e6d215b3f0
https://doi.org/10.1055/s-0035-1561278
https://doi.org/10.1055/s-0035-1561278
Autor:
Sebastian Essig, Dirk Menche
Publikováno v:
Pure and Applied Chemistry. 85:1103-1120
Polyketides are a very diverse family of natural products with an extremely broad range of biological activities and pharmacological properties, including antiproliferative, antibiotic, antifungal, or antiplasmodial activities, and in many cases spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d776cbed6141fa099c1494f1447334d6
https://doi.org/10.1351/pac-con-12-09-12
https://doi.org/10.1351/pac-con-12-09-12
Autor:
Dirk Menche, Sebastian Essig
Publikováno v:
The Journal of organic chemistry. 81(5)
Full details on the design, development, and application of a highly stereoselective strategy for the synthesis of isochromanones are reported. The method is based on an asymmetric ortho lithiation with aldehyde electrophiles and utilizes the chiral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c1be690c459aba75ff22677c7bc0b5
https://pubmed.ncbi.nlm.nih.gov/26824669
https://pubmed.ncbi.nlm.nih.gov/26824669
Autor:
Olga Scherer, Sebastian Essig, Dirk Menche, Björn Schmalzbauer, Oliver Werz, Andreas Koeberle, Rolf Müller, Sebastian Bretzke
Publikováno v:
The Journal of organic chemistry. 81(4)
Full details on the evaluation and application of an easily feasible and generally useful method for configurational assignments of isolated methyl-bearing stereocenters are reported. The analytical tool relies on a bioinformatic gene cluster analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e02ba3c7b145953a4aa163d9f8aef4f
https://pubmed.ncbi.nlm.nih.gov/26796481
https://pubmed.ncbi.nlm.nih.gov/26796481
Autor:
Helmut Wieczorek, Florenz Sasse, Markus Huss, Sebastian Essig, Svenja Bockelmann, Dirk Menche, Nicole Horstmann
Publikováno v:
Journal of Natural Products. 74:1100-1105
Two structurally novel analogues of the macrolides archazolids A and B, archazolid A-15-O-β-D-glucopyranoside (archazolid E, 5) and iso-archazolid B (archazolid F, 6), were isolated from the myxobacterium Cystobacter violaceus and Archangium gephyra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f147b7e022ec9ca4c26338f8eaf222
https://doi.org/10.1021/np200036v
https://doi.org/10.1021/np200036v
The rapid and selective regulation of a target protein within living cells that contain closely related family members is an outstanding challenge. Here we introduce genetically directed bioorthogonal ligand tethering (BOLT) and demonstrate selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdec485f3d0b26b396acf80f42d63ca
https://europepmc.org/articles/PMC4673907/
https://europepmc.org/articles/PMC4673907/
