Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sebastian Enck"'
Publikováno v:
European Journal of Organic Chemistry. 2015:7443-7448
Substitution of a peptide bond for an imine transforms the irreversible macrocyclization of peptides into a reversible process. The inherent cyclization tendency of a linear peptide is then analyzable through the equilibrium between the aldehyde and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1f472bafb8e2013313d7ecacba7f6f8
https://doi.org/10.1002/ejoc.201501179
https://doi.org/10.1002/ejoc.201501179
Autor:
Lin-Ya Huang, Ting-Jen R. Cheng, Yi-Fan Chang, Shih-Hsien Huang, Mathias Schelwies, Che-Hsiung Hsu, Chi-Huey Wong, Sebastian Enck, Wei-Chieh Cheng
Publikováno v:
The Journal of Organic Chemistry
We herein describe the first synthesis of iminosugar C-glycosides of α-D-GlcNAc-1-phosphate in 10 steps starting from unprotected D-GlcNAc. A diastereoselective intramolecular iodoamination-cyclization as the key step was employed to construct the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c593eac4f6db4c0d5b511f3e5ea1af5
https://doi.org/10.1021/jo501340s
https://doi.org/10.1021/jo501340s
Publikováno v:
Tetrahedron. 68:7166-7178
We present the stereoselective synthesis of various highly functionalized thiazole dipeptides that are found in thiopeptide antibiotics like thiazomycins and nocathiacins. The condensation of an uronic acid with l -cysteine methyl ester delivers alon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b1a61fdbe38dda6bb998a2f23507e8
https://doi.org/10.1016/j.tet.2012.06.022
https://doi.org/10.1016/j.tet.2012.06.022
Publikováno v:
Journal of the American Chemical Society. 130:8326-8336
Whereas the C-terminal fragment of neuropeptide Y (NPY) has been structurally well-defined both in solution and as membrane-bound, detailed structural information regarding the proline-rich N-terminus is still missing. The systematic variation of eac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f878288a9b61cc45dc4b7f00ca58ca
https://doi.org/10.1021/ja8004495
https://doi.org/10.1021/ja8004495
Publikováno v:
ACS chemical biology. 8(10)
N-glycans play important roles in many cellular processes and can increase protein conformational stability in specific structural contexts. Glycosylation (with a single GlcNAc) of the reverse turn sequence Phe-Yyy-Asn-Xxx-Thr at Asn stabilizes the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c1316239b0652001376f3931e9b4c4
https://pubmed.ncbi.nlm.nih.gov/23937634
https://pubmed.ncbi.nlm.nih.gov/23937634
Autor:
Sebastian Enck, Joshua L. Price, H. Jane Dyson, Jeffery W. Kelly, David L. Powers, Wentao Chen, Chi-Huey Wong, Evan T. Powers
Publikováno v:
Journal of the American Chemical Society. 135(26)
Carbohydrate-aromatic interactions mediate many biological processes. However, the structure-energy relationships underpinning direct carbohydrate-aromatic packing interactions in aqueous solution have been difficult to assess experimentally and rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9687520b60741a50a2d39aac2f1b593c
https://pubmed.ncbi.nlm.nih.gov/23742246
https://pubmed.ncbi.nlm.nih.gov/23742246
Publikováno v:
Organicbiomolecular chemistry. 8(3)
In spite of the important role of peptide macrocyclizations for the generation of conformationally constrained biological ligands, our knowledge of factors that determine the inclination of a substrate to cyclize is low. Therefore, methods that give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fdfb91033289c86a8105d9a5ad3416
https://pubmed.ncbi.nlm.nih.gov/20090972
https://pubmed.ncbi.nlm.nih.gov/20090972
Publikováno v:
Chembiochem : a European journal of chemical biology. 9(16)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268f384f2ba9a72d20f69e79cae233b6
https://pubmed.ncbi.nlm.nih.gov/18821552
https://pubmed.ncbi.nlm.nih.gov/18821552