Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Sebastian E Ahnert"'
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1006886 (2019)
The self-assembly of proteins into protein quaternary structures is of fundamental importance to many biological processes, and protein misassembly is responsible for a wide range of proteopathic diseases. In recent years, abstract lattice models of
Externí odkaz:
https://doaj.org/article/373d859ee3134cd28b55a49c016a453a
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004773 (2016)
Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to share characteristics than expected from random chance. Such genetic correlations should strongly influence evolutionary dynamics. We explore and quant
Externí odkaz:
https://doaj.org/article/685fab11b49747a1abcd8f6f6a778c81
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103500 (2014)
The provision of healthcare in rural African communities is a highly complex and largely unsolved problem. Two main difficulties are the identification of individuals that are most likely affected by disease and the prediction of responses to health
Externí odkaz:
https://doaj.org/article/ab6605f230a9411fa4627ed35178b3b9
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113685 (2014)
Competition is ubiquitous in many complex biological, social, and technological systems, playing an integral role in the evolutionary dynamics of the systems. It is often useful to determine the dominance hierarchy or the rankings of the components o
Externí odkaz:
https://doaj.org/article/6a1a261f1cd245ba84dffcdf4560088e
Autor:
Susanna Manrubia, José A. Cuesta, Jacobo Aguirre, Sebastian E. Ahnert, Lee Altenberg, Alejandro V. Cano, Pablo Catalán, Ramon Diaz-Uriarte, Santiago F. Elena, Juan Antonio García-Martín, Paulien Hogeweg, Bhavin S. Khatri, Joachim Krug, Ard A. Louis, Nora S. Martin, Joshua L. Payne, Matthew J. Tarnowski, Marcel Weiß
Publikováno v:
Physics of Life Reviews. 42:19-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20aeafe2ae40e20b2c2dfe984bb042c9
https://doi.org/10.1016/j.plrev.2022.05.007
https://doi.org/10.1016/j.plrev.2022.05.007
Autor:
Vaibhav Mohanty, Sam F. Greenbury, Tasmin Sarkany, Shyam Narayanan, Kamaludin Dingle, Sebastian E. Ahnert, Ard A. Louis
Phenotype robustness, defined as the average mutational robustness of all the genotypes that map to a given phenotype, plays a key role in facilitating neutral exploration of novel phenotypic variation by an evolving population. By applying results f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e51da3cbcac5a9e06447fd53944b808
https://doi.org/10.1101/2023.03.11.532236
https://doi.org/10.1101/2023.03.11.532236
Selection and variation are both key aspects in the evolutionary process. Previous research on the mapping between molecular sequence (genotype) and molecular fold (phenotype) has shown the presence of several structural properties in different biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b3df9bf311fc5195acdaaf6fd5ae2f5
https://doi.org/10.1101/2023.02.27.530309
https://doi.org/10.1101/2023.02.27.530309
Autor:
Nora S. Martin, Sebastian E. Ahnert
New folded molecular structures can only evolve after arising through mutations. This aspect is modelled using genotype-phenotype (GP) maps, which connect sequence changes through mutations to changes in molecular structures. Previous work has shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caad1c2622e6d2f25182dd3913d85bf2
https://doi.org/10.1101/2023.02.22.529545
https://doi.org/10.1101/2023.02.22.529545
Fitness landscapes are often described in terms of ‘peaks’ and ‘valleys’, implying an intuitive low-dimensional landscape of the kind encountered in everyday experience. The space of genotypes, however, is extremely high-dimensional, which re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20cc91075ef0852cc80f1386b862aa8
https://www.repository.cam.ac.uk/handle/1810/338241
https://www.repository.cam.ac.uk/handle/1810/338241