Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study

Autor: Mariangela Pellegrini, Mayson L. A. Sousa, Sebastian Dubo, Luca S. Menga, Vanessa Hsing, Martin Post, Laurent J. Brochard

Publikováno v: Annals of Intensive Care, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Background Efficacy of inhaled therapy such as Nitric Oxide (iNO) during mechanical ventilation may depend on airway patency. We hypothesized that airway closure and lung collapse, countered by positive end-expiratory pressure (PEEP), influe

Externí odkaz: https://doaj.org/article/6162bf44baa74f5fa12df901b5832b17

Closed‐loop parameter optimisation for patient‐specific phrenic nerve stimulation

Autor: Conor Keogh, Francisco Saavedra, Sebastian Dubo, Pablo Aqueveque, Paulina Ortega, Britam Gomez, Enrique Germany, Daniela Pinto, Rodrigo Osorio, Francisco Pastene, Adrian Poulton, Jonathan Jarvis, Brian Andrews, James J. FitzGerald

Publikováno v: Artificial Organs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bee8e95e6a5cbe99fc0eb78bab6c6595
https://doi.org/10.1111/aor.14593

Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients

Autor: Jan O. Friedrich, Sebastian Dubo, Ewan C. Goligher, Leo M. A. Heunks, Michael C. Sklar, Fabiana Madotto, Michela Rauseo, Ibrahim Soliman, Ricard M. Artigas, Nuttapol Rittayamai, L. Felipe Damiani, Rémi Coudroy, Lu Chen, Irene Telias, Annemijn H. Jonkman, Guang-Qiang Chen, Laurent Brochard, Tài Pham, Martin Dres, Christer Sinderby

Publikováno v: Sklar, M C, Madotto, F, Jonkman, A, Rauseo, M, Soliman, I, Damiani, L F, Telias, I, Dubo, S, Chen, L, Rittayamai, N, Chen, G-Q, Goligher, E C, Dres, M, Coudroy, R, Pham, T, Artigas, R M, Friedrich, J O, Sinderby, C, Heunks, L & Brochard, L 2021, ' Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients ', Critical Care, vol. 25, no. 1, 26 . https://doi.org/10.1186/s13054-020-03435-y
Critical Care, Vol 25, Iss 1, Pp 1-15 (2021)
Critical Care
Critical Care, 25(1):26. Springer Science + Business Media
Critical Care, BioMed Central, 2021, 25 (1), pp.26. ⟨10.1186/s13054-020-03435-y⟩
Critical Care, 2021, 25 (1), pp.26. ⟨10.1186/s13054-020-03435-y⟩

BackgroundIn patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and patient severity.MethodsProspectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b4bdd25988a25831788289fb03e1bb
https://research.vumc.nl/en/publications/432cd363-8473-434a-9d53-34100151d10a

Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?

Autor: Sebastián Dubo, Emilio Daniel Valenzuela, Andrés Aquevedo, Manuel Jibaja, Dolores Berrutti, Christian Labra, Rossana Lagos, María Fernanda García, Vanessa Ramírez, Milton Tobar, Fabricio Picoita, Cristian Peláez, David Carpio, Leyla Alegría, Carolina Hidalgo, Karen Godoy, Alejandro Bruhn, Glenn Hernández, Jan Bakker, Ricardo Castro

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0225181 (2019)

BACKGROUND:The spontaneous breathing trial (SBT) assesses the risk of weaning failure by evaluating some physiological responses to the massive venous return increase imposed by discontinuing positive pressure ventilation. This trial can be very dema

Externí odkaz: https://doaj.org/article/66990451c9d742e2a0499e73bab047bd