Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Sebastian Brachs"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionHolistic phenotyping of rodent models is increasing, with a growing awareness of the 3Rs and the fact that specialized experimental setups can also impose artificial restrictions. Activity is an important parameter for almost all basic an
Externí odkaz:
https://doaj.org/article/84e750cc8cf74c7f9955627d31baedc4
Autor:
Essaikiammal Sodalai Muthu Konar, Knut Mai, Sebastian Brachs, Swapnil Gorakh Waghmare, Azadeh Mohagheghi Samarin, Tomas Policar, Azin Mohagheghi Samarin
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionPost-ovulatory aging is a time-dependent deterioration of ovulated oocytes and a major limiting factor reducing the fitness of offspring. This process may lead to the activation of cell death pathways like apoptosis in oocytes.Methodology
Externí odkaz:
https://doaj.org/article/d6e0d6ada12e4a2bba167b5ea9c91aa9
Autor:
Leontine Sandforth, Sebastian Brachs, Julia Reinke, Diana Willmes, Gencer Sancar, Judith Seigner, David Juarez-Lopez, Arvid Sandforth, Jeffrey D. McBride, Jian-Xing Ma, Sven Haufe, Jens Jordan, Andreas L. Birkenfeld
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101905- (2024)
Objective: Kallistatin (KST), also known as SERPIN A4, is a circulating, broadly acting human plasma protein with pleiotropic properties. Clinical studies in humans revealed reduced KST levels in obesity. The exact role of KST in glucose and energy h
Externí odkaz:
https://doaj.org/article/8029e4df1a684f388440b641e51135c4
Autor:
Julia Sbierski-Kind, Sophia Grenkowitz, Stephan Schlickeiser, Arvid Sandforth, Marie Friedrich, Désirée Kunkel, Rainer Glauben, Sebastian Brachs, Knut Mai, Andrea Thürmer, Aleksandar Radonić, Oliver Drechsel, Peter J. Turnbaugh, Jordan E. Bisanz, Hans-Dieter Volk, Joachim Spranger, Reiner Jumpertz von Schwartzenberg
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Background Caloric restriction can delay the development of metabolic diseases ranging from insulin resistance to type 2 diabetes and is linked to both changes in the composition and metabolic function of the gut microbiota and immunological
Externí odkaz:
https://doaj.org/article/d228d7c5d3a2491ebb31174f3078a8fd
Autor:
Julianna D. Zeidler, Claudia C.S. Chini, Karina S. Kanamori, Sonu Kashyap, Jair M. Espindola-Netto, Katie Thompson, Gina Warner, Fernanda S. Cabral, Thais R. Peclat, Lilian Sales Gomez, Sierra A. Lopez, Miles K. Wandersee, Renee A. Schoon, Kimberly Reid, Keir Menzies, Felipe Beckedorff, Joel M. Reid, Sebastian Brachs, Ralph G. Meyer, Mirella L. Meyer-Ficca, Eduardo Nunes Chini
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105431- (2022)
Summary: In mammals, nicotinamide (NAM) is the primary NAD precursor available in circulation, a signaling molecule, and a precursor for methyl-nicotinamide (M-NAM) synthesis. However, our knowledge about how the body regulates tissue NAM levels is s
Externí odkaz:
https://doaj.org/article/141dbe6e1aae41299df7a3192ac2247c
Autor:
Linna Li, Leonard Spranger, Nicole Stobäus, Finja Beer, Anne-Marie Decker, Charlotte Wernicke, Sebastian Brachs, Maria Brachs, Joachim Spranger, Knut Mai
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Background/objectives Numerous hepatokines are involved in inter-organ cross talk regulating tissue-specific insulin sensitivity. Adipose tissue lipolysis represents a crucial element of adipose insulin sensitivity and is substantially invol
Externí odkaz:
https://doaj.org/article/92ed883e4fe047988edfd4b9aa2c96c4
Autor:
Olena Mackert, Eva Katrin Wirth, Rongwan Sun, Jennifer Winkler, Aoxue Liu, Kostja Renko, Séverine Kunz, Joachim Spranger, Sebastian Brachs
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101563- (2022)
Objective: Alterations in mitochondrial function play an important role in the development of various diseases, such as obesity, insulin resistance, steatohepatitis, atherosclerosis and cancer. However, accurate assessment of mitochondrial respiratio
Externí odkaz:
https://doaj.org/article/8505d120091843a08eabbb00618e365e
Autor:
David Lohr, Arne Thiele, Max Stahnke, Vera Braun, Elia Smeir, Joachim Spranger, Sebastian Brachs, Robert Klopfleisch, Anna Foryst-Ludwig, Laura M. Schreiber, Ulrich Kintscher, Niklas Beyhoff
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundObesity exerts multiple deleterious effects on the heart that may ultimately lead to cardiac failure. This study sought to characterize myocardial microstructure and function in an experimental model of obesity-related cardiac dysfunction.M
Externí odkaz:
https://doaj.org/article/f61a6287ebfa4d6b852632693ca330ce
Autor:
Martin Regensburger, Iryna Prots, Dorothea Reimer, Sebastian Brachs, Sandra Loskarn, Dieter Chichung Lie, Dirk Mielenz, Beate Winner
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 347-355 (2018)
Summary: Swiprosin-1/Efhd2 (Efhd2) is highly expressed in the CNS during development and in the adult. EFHD2 is regulated by Ca2+ binding, stabilizes F-actin, and promotes neurite extension. Previous studies indicated a dysregulation of EFHD2 in huma
Externí odkaz:
https://doaj.org/article/af1574b7ef56425c96426e76eda0797f
Autor:
Sebastian Brachs, Angelika F. Winkel, Hui Tang, Andreas L. Birkenfeld, Bodo Brunner, Kerstin Jahn-Hofmann, Daniel Margerie, Hartmut Ruetten, Dieter Schmoll, Joachim Spranger
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1072-1082 (2016)
Objective: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotrans
Externí odkaz:
https://doaj.org/article/e5e65e2ccada43378f7614a3e68e2670