Zobrazeno 1 - 10 of 258 pro vyhledávání: '"Sebastian Belle"'
1
Akademický článek
The drug-induced phenotypic landscape of colorectal cancer organoids
Autor: Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, Timo Gaiser, Inga Buchholz, Ralf Jesenofsky, Nicolai Härtel, Tianzuo Zhan, Bernd Fischer, Katja Breitkopf-Heinlein, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The heterogeneity underlying cancer organoid phenotypes is not yet well understood. Here, the authors develop an imaging analysis assay for high throughput phenotypic screening of colorectal organoids that allows to define specific morphological chan
Externí odkaz: https://doaj.org/article/781b445e149e41f2a3b65e3af8beee8f
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2
Akademický článek
Detection of mutational patterns in cell‐free DNA of colorectal cancer by custom amplicon sequencing
Autor: Simon Herrmann, Tianzuo Zhan, Johannes Betge, Benedikt Rauscher, Sebastian Belle, Tobias Gutting, Nadine Schulte, Ralf Jesenofsky, Nicolai Härtel, Timo Gaiser, Ralf‐Dieter Hofheinz, Matthias P. Ebert, Michael Boutros
Publikováno v: Molecular Oncology, Vol 13, Iss 8, Pp 1669-1683 (2019)
Monitoring the mutational patterns of solid tumors during cancer therapy is a major challenge in oncology. Analysis of mutations in cell‐free (cf) DNA offers a noninvasive approach to detect mutations that may be prognostic for disease survival or
Externí odkaz: https://doaj.org/article/0245d7ee846f4ae8a240a734bcbc0d3b
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3
Akademický článek
A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA)
Autor: Nadja M. Meindl-Beinker, Johannes Betge, Tobias Gutting, Elke Burgermeister, Sebastian Belle, Tianzuo Zhan, Nadine Schulte, Martin Maenz, Matthias P. Ebert, Nicolai Haertel
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Advanced esophageal squamous cell cancer (ESCC) is frequently diagnosed in elderly patients. The impact of 2nd line chemotherapy is poorly defined. Recent data demonstrated effectiveness of checkpoint inhibitors in different squam
Externí odkaz: https://doaj.org/article/213aab5f04994d7d828225467c3dd8b1
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4
Akademický článek
PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells
Autor: Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka, Elke Burgermeister
Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
Only a small subset of colorectal cancer (CRC) patients benefits from immunotherapies, comprising blocking antibodies (Abs) against checkpoint receptor “programmed-cell-death-1” (PD1) and its ligand (PD-L1), because most cases lack the required m
Externí odkaz: https://doaj.org/article/76d82438b7e2457c9fd5fa68a566c022
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5
Endoskopisches Komplikationsmanagment nach bariatrischen Operationen mit dem Fokus auf die aktuellen endoskopischen Therapien
Autor: Sebastian Belle, Konstantinos Kouladouros, Georg Kähler
Publikováno v: Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie. 147:539-546
ZusammenfassungKomplikationen nach bariatrischer Chirurgie sind selten. Die meisten Komplikationen lassen sich endoskopisch oder mithilfe der Endoskopie therapieren. Das Seltene stellt jedoch im klinischen Alltag eine Herausforderung dar. Damit die K
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b609345c21ed9b066310039d9f6fff3
https://doi.org/10.1055/a-1962-6910
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6
Akademický článek
A multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/− nab-paclitaxel in elderly pancreatic cancer patients (GrantPax)
Autor: Johannes Betge, Jing Chi-Kern, Nadine Schulte, Sebastian Belle, Tobias Gutting, Elke Burgermeister, Ralf Jesenofsky, Martin Maenz, Ulrich Wedding, Matthias P. Ebert, Nicolai Haertel
Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018)
Abstract Background In the group of elderly patients (≥70 years) with metastatic pancreatic ductal adenocarcinoma (mPDAC), it is not known who benefits from intensive 1st line nab-paclitaxel/gemcitabine (nab-p/gem) combination chemotherapy or who w
Externí odkaz: https://doaj.org/article/1b0752c83e964285a87408a0460a531c
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10
Expression of the EGFR-RAS Inhibitory Proteins DOK1 and MTMR7 and its Significance in Colorectal Adenoma and Adenoma Recurrence
Autor: Tobias, Gutting, Andreas, Merkel, David J, Fink, Svetlana, Hetjens, Philip, Weidner, Yanxiong, Yu, Georg, Kähler, Matthias P, Ebert, Timo, Gaiser, Elke, Burgermeister, Sebastian, Belle
Publikováno v: Journal of Gastrointestinal and Liver Diseases. 30:446-455
Background and Aims: Colorectal adenomas are precursor lesions for colorectal cancer (CRC), a major cause of cancer-related death. Despite all molecular insights, there are still unknown variables in the development of CRC as well as uncertainties re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e6b7a0e142588b31386314086258ea
https://doi.org/10.15403/jgld-3681
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