Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Sebastian Barg"'
Autor:
Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kina
Externí odkaz:
https://doaj.org/article/07e41593908f4d84a89d335f3da86332
Autor:
Chen Liu, Andriani Mentzelopoulou, Fotini Papagavriil, Prashanth Ramachandran, Artemis Perraki, Lucas Claus, Sebastian Barg, Peter Dörmann, Yvon Jaillais, Philipp Johnen, Eugenia Russinova, Electra Gizeli, Gabriel Schaaf, Panagiotis Nikolaou Moschou
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002305 (2023)
Protein function can be modulated by phase transitions in their material properties, which can range from liquid- to solid-like; yet, the mechanisms that drive these transitions and whether they are important for physiology are still unknown. In the
Externí odkaz:
https://doaj.org/article/e2a44caa675b4120a3b674204b069a27
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112036- (2023)
Summary: Phosphatidylinositol(4,5)bisphosphate (PI(4,5)P2) is an important signaling phospholipid that is required for regulated exocytosis and some forms of endocytosis. The two processes share a topologically similar pore structure that connects th
Externí odkaz:
https://doaj.org/article/73360117586d43abba0cc01632454d95
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin
Externí odkaz:
https://doaj.org/article/e632b127eee5439face77166a636f601
Autor:
Sergiy V. Korol, Zhe Jin, Yang Jin, Amol K. Bhandage, Anders Tengholm, Nikhil R. Gandasi, Sebastian Barg, Daniel Espes, Per-Ola Carlsson, Derek Laver, Bryndis Birnir
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 273-282 (2018)
In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human is
Externí odkaz:
https://doaj.org/article/1bc71a74c5a548beb4885579c8991456
Autor:
Alenka Guček, Nikhil R Gandasi, Muhmmad Omar-Hmeadi, Marit Bakke, Stein O Døskeland, Anders Tengholm, Sebastian Barg
Publikováno v:
eLife, Vol 8 (2019)
Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like insulin requires further expa
Externí odkaz:
https://doaj.org/article/f3583b0e1c3843dc81713366c995681e
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167282 (2016)
Hormones and neurotransmitters are released when secretory granules or synaptic vesicles fuse with the cell membrane, a process denoted exocytosis. Modern imaging techniques, in particular total internal reflection fluorescence (TIRF) microscopy, all
Externí odkaz:
https://doaj.org/article/2777d46aa2884ea5b0ac8bb82c8eb63b
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127801 (2015)
Fluorescent proteins (FPs) have proven to be valuable tools for high-resolution imaging studies of vesicle transport processes, including exo- and endocytosis. Since the pH of the vesicle lumen changes between acidic and neutral during these events,
Externí odkaz:
https://doaj.org/article/03525fd23a4f41f2b5c02bf89336d2b6
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67228 (2013)
In the rat islets γ-aminobutyric acid (GABA) is produced by the β-cells and, at least, the α-cells express the GABA(A) receptors (GABA(A) channels). In this study, we examined in intact islets if the interstitial GABA activated the GABA(A) recepto
Externí odkaz:
https://doaj.org/article/f1e4995e9319427a81dd2186f89fbf50
Autor:
Stefanie Obermüller, Federico Calegari, Angus King, Anders Lindqvist, Ingmar Lundquist, Albert Salehi, Maura Francolini, Patrizia Rosa, Patrik Rorsman, Wieland B Huttner, Sebastian Barg
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8936 (2010)
Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B
Externí odkaz:
https://doaj.org/article/dc6cb480a3934b038bec420cb3830119