Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sebastian B Arredondo"'
Autor:
Sebastian B. Arredondo, Daniel T. Reyes, Andrea Herrera-Soto, Muriel D. Mardones, Nibaldo C. Inestrosa, Lorena Varela-Nallar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In Alzheimer´s disease (AD) there is a reduction in hippocampal neurogenesis that has been associated to cognitive deficits. Previously we showed that Andrographolide (ANDRO), the main bioactive component of Andrographis paniculate, induces
Externí odkaz:
https://doaj.org/article/ca4b966c21c9405888f78dead9baf1c9
Autor:
Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Muriel D. Mardones, Lorena Varela-Nallar
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dent
Externí odkaz:
https://doaj.org/article/64293ae60d764ac59effa6232ee3b4f3
Autor:
Andrea Herrera-Soto, Sebastian B. Arredondo, Lorena Varela-Nallar, Muriel D. Mardones, Daniel T. Reyes, Nibaldo C. Inestrosa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
In Alzheimer´s disease (AD) there is a reduction in hippocampal neurogenesis that has been associated to cognitive deficits. Previously we showed that Andrographolide (ANDRO), the main bioactive component of Andrographis paniculate, induces prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efe213d97ece946522f6baf01dcb6bf
https://doaj.org/article/ca4b966c21c9405888f78dead9baf1c9
https://doaj.org/article/ca4b966c21c9405888f78dead9baf1c9
Autor:
David M. Valenzuela, Ursula Wyneken, Waldo Cerpa, Sebastian B. Arredondo, Alfonso González, Lorena Varela-Nallar, Francisco J. Carvajal, Francisca Barake, Sofía Espinoza, Alejandro Rojas-Fernandez, Fernanda G. Guerrero, Fabián Segovia-Miranda, Loreto Massardo
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-17 (2020)
BMC Biology
BMC Biology
Background Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediated by cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9f9f1510edfae221211ebbebffc51b
http://link.springer.com/article/10.1186/s12915-020-00877-2
http://link.springer.com/article/10.1186/s12915-020-00877-2
Autor:
Lorena Varela-Nallar, Sebastian B. Arredondo, Cheril Tapia-Rojas, Juan Hancke, Nibaldo C. Inestrosa
Publikováno v:
Neural Plasticity, Vol 2015 (2015)
Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti-inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3β (GSK-3β), a key
Externí odkaz:
https://doaj.org/article/1d48c9dc7c75488485ffe526985498a3
Autor:
Gabriela A. Andaur, Felipe Salech, Daniel B. Bustamante, Andrés Couve, Sebastian B. Arredondo, Rodrigo Cisneros, Nibaldo C. Inestrosa, Patricia Ayala, Maria I. Behrens, José Luis Valdés, Daniela P. Ponce, Lorena Varela-Nallar
Publikováno v:
The Journals of Gerontology: Series A. 74:1043-1051
Klotho is an aging-related protein associated with hippocampal cognitive performance in mammals. Klotho regulates progenitor cell proliferation in non-neuronal tissues, but its role in adult hippocampal neurogenesis (AHN) has not been explored. Kloth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299d2ddcecc9e5339a1b8471d52f76a8
https://doi.org/10.1093/gerona/glx248
https://doi.org/10.1093/gerona/glx248
Autor:
Andrea Herrera-Soto, Manuel Varas-Godoy, Alejandro Oñate-Ponce, Daniel B. Bustamante, Nibaldo C. Inestrosa, Joaquin Jensen-Flores, Pablo Henny, Fernanda G. Guerrero, Sebastian B. Arredondo, Lorena Varela-Nallar
Publikováno v:
Stem cells (Dayton, Ohio)REFERENCES. 38(3)
In the adult hippocampus, new neurons are generated in the dentate gyrus. The Wnt signaling pathway regulates this process, but little is known about the endogenous Wnt ligands involved. We investigated the role of Wnt5a on adult hippocampal neurogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291500a7e4cad572710c2410dbb43502
https://pubmed.ncbi.nlm.nih.gov/31721364
https://pubmed.ncbi.nlm.nih.gov/31721364
Autor:
Paulina Salazar, Salesa Barja, Felipe Serrano, Sebastian B. Arredondo, Carla Montecinos-Oliva, Pedro Cisternas, Nibaldo C. Inestrosa, Fernando Gomez-Pinilla, Carlos P. Vio, Lorena Varela-Nallar
Publikováno v:
Biochimica et biophysica acta, vol 1852, iss 11
Biochimica et Biophysica Acta-Molecular Basis of Disease
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Biochimica et Biophysica Acta-Molecular Basis of Disease
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Metabolic syndrome (MetS) is a global epidemic, which involves a spectrum of metabolic disorders comprising diabetes and obesity. The impact of MetS on the brain is becoming to be a concern, however, the poor understanding of mechanisms involved has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be91cf847586402df9c4d72ea1338e99
https://doi.org/10.1016/j.bbadis.2015.08.016
https://doi.org/10.1016/j.bbadis.2015.08.016
Autor:
Lorena Varela-Nallar, Sebastian B. Arredondo, Daniela Sauma, Mario Rosemblatt, Leonardo Vargas, Felipe Flores-Santibáñez, Victoria Guixé, María Rosa Bono, Gabriela Tejón, Daniel Meza, Dominique Fernández
The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in the presence of transformin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e9935a637daab412c1632618fce2db
https://europepmc.org/articles/PMC4693903/
https://europepmc.org/articles/PMC4693903/
Autor:
Andrés Couve, Maria I. Behrens, Sebastian B. Arredondo, Lorena Varela-Nallar, Daniel B. Bustamante, D. Ponce de la Vega, Nibaldo C. Inestrosa, Felipe Salech
Publikováno v:
Journal of the Neurological Sciences. 357:e248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86c32b8eeca053078d1e0cc7a6ce1f70
https://doi.org/10.1016/j.jns.2015.08.865
https://doi.org/10.1016/j.jns.2015.08.865