Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

Autor: Harald H.H.W. Schmidt, Ulla G. Knaus, Mayra P. Pachado, Mahmoud H. Elbatreek, Christopher T. Neullens, Sebastian Altenhöfer, Vu Thao-Vi Dao, Ana I. Casas

Publikováno v: Free Radical Biology and Medicine, 148, 60-69. Elsevier Science
Free Radical Biology and Medicine

Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however, has failed in multiple clinical trials to provide patient benefit. Instead,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b1439084aae1f7e843ab4206f951aa
https://doi.org/10.1016/j.freeradbiomed.2019.12.038

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

Autor: Christoph Kleinschnitz, Kirstin Wingler, Sebastian Altenhöfer, Friederike Langhauser, Kim A. Radermacher, Pamela W. M. Kleikers, Harald H.H.W. Schmidt, Martin Hrabě de Angelis, J. J. Rob Hermans

Publikováno v: Antioxidants & Redox Signaling, 18(12), 1418-1427. Mary Ann Liebert Inc.
Antioxidants & Redox Signaling
Antioxid. Redox Signal. 18, 1418-1427 (2013)

Significance: Stroke, a leading cause of death and disability, poses a substantial burden for patients, relatives, and our healthcare systems. Only one drug is approved for treating stroke, and more than 30 contraindications exclude its use in 90% of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33006be7fcc9c9d8ee985eeb92d043c1
https://doi.org/10.1089/ars.2012.4797

One Enzyme, Two Functions

Autor: Sebastian Altenhöfer, Albrecht M. Clement, John F. Teiber, Sven Horke, Heidrun Witan, Andrea Pautz, Ulrich Förstermann, Petra Wilgenbus, Ines Witte, Andreas Daiber, Huige Li

Publikováno v: Journal of Biological Chemistry. 285:24398-24403

The human enzyme paraoxonase-2 (PON2) has two functions, an enzymatic lactonase activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly hydrolyzes bacterial signaling molecule 3OC12 and may contribute to the defens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8030f93a02da0ed78e7d2a30b90879a
https://doi.org/10.1074/jbc.m110.118604

Similar Regulation of Human Inducible Nitric-oxide Synthase Expression by Different Isoforms of the RNA-binding Protein AUF1

Autor: Sebastian Heil, Nadine Schmidt, Hartmut Kleinert, Andrea Pautz, Robert J. Schneider, Adam R. Pont, Sebastian Altenhöfer, Shirley K. Knauer, Julia Art, Roland H. Stauber, Navid Sadri, Katrin Linker

Publikováno v: Journal of Biological Chemistry. 284:2755-2766

The ARE/poly-(U) binding factor 1 (AUF1), a protein family consisting of four isoforms, is believed to mediate mRNA degradation by binding to AU-rich elements (ARE). However, evidence exists that individual AUF1 isoforms may stabilize ARE-containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bacbb14102f4f1f08384ba189a9017f
https://doi.org/10.1074/jbc.m809314200

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Autor: Sebastian Altenhöfer, Heidi Ho, Paul M. H. Schiffers, Kirstin Wingler, Pamela W. M. Kleikers, Peter Scheurer, Kim A. Radermacher, Harald H.H.W. Schmidt, J. J. Rob Hermans

Publikováno v: Cellular and Molecular Life Sciences, 69(14), 2327-2343. Springer
Cellular and Molecular Life Sciences

Reactive oxygen species (ROS) are cellular signals but also disease triggers; their relative excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents are potentially deleterious. This may explain why antioxidants fail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b719b7a600434e2f2659f234866b54a
https://cris.maastrichtuniversity.nl/en/publications/673a541e-668a-4157-9c0c-06e6951529b6