Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sebastian Alers"'
Autor:
Sebastian Alers
Publikováno v:
ScienceOpen Research (2015)
Dear Reader, Welcome to the inaugural Editorial of a unique journal: ScienceOpen Research. The birth of the academic journal goes back more than 300 years, when the very first volume of the Philosophical Transactions was published by the Royal
Externí odkaz:
https://doaj.org/article/66671c093c3f4c878f5d08f344d440c3
Autor:
Antje S. Löffler, Tomohiro Kurosaki, Alexander Gray, Michael Engelke, Christoph Peter, Sebastian Alers, Nora Hieke, S Pietkiewicz, Björn Stork, M Bonin, Nick R. Leslie, Stefan Drießen, Alexandra M. Dieterle, Sebastian Wesselborg, Hildegard Keppeler, Hisaaki Shinohara, Niklas Berleth, Jürgen Wienands, Philip Böhler
Publikováno v:
Oncogene. 33:3043-3053
The PI3K/PDK1/Akt signaling axis is centrally involved in cellular homeostasis and controls cell growth and proliferation. Due to its key function as regulator of cell survival and metabolism, the dysregulation of this pathway is manifested in severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e58fc88defa7e4ebd0300058372e21
https://doi.org/10.1038/onc.2013.266
https://doi.org/10.1038/onc.2013.266
Autor:
David G. Campbell, Mirita Franz-Wachtel, Antje S. Löffler, Mondira Kundu, Sebastian Wesselborg, Sebastian Alers, Björn Stork, Hildegard Keppeler, Dario R. Alessi, Alexandra M. Dieterle
Publikováno v:
Autophagy. 7:696-706
Unc-51-like kinase 1 (Ulk1) plays a central role in autophagy induction. It forms a stable complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP 200). This complex is negatively regulated by the mammalian targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad3ef9675f8a92b341dedc277389854
https://doi.org/10.4161/auto.7.7.15451
https://doi.org/10.4161/auto.7.7.15451
Autor:
Björn Stork, Michael Naumann, Sebastian Alers, Michael Engelke, Ingo Goldbeck, Thilo Kähne, Jürgen Wienands, Konstantin Neumann
Publikováno v:
The EMBO Journal. 26:1140-1149
Spatial and temporal modulation of intracellular Ca2+ fluxes controls the cellular response of B lymphocytes to antigen stimulation. Herein, we identify the hematopoietic adaptor protein Dok-3 (downstream of kinase-3) as a key component of negative f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7226843fd510e6f4d25745c1d92e5ba8
https://doi.org/10.1038/sj.emboj.7601557
https://doi.org/10.1038/sj.emboj.7601557
Autor:
Birgit Fehrenbacher, Kirsten Lauber, Martin Schaller, David G. Campbell, Sebastian Alers, Alexandra M. Dieterle, Björn Stork, Sebastian Wesselborg, Florian Paasch, Hildegard Keppeler, Antje S. Löffler
Publikováno v:
Autophagy. 7(12)
Under normal growth conditions the mammalian target of rapamycin complex 1 (mTORC1) negatively regulates the central autophagy regulator complex consisting of Unc-51-like kinases 1/2 (Ulk1/2), focal adhesion kinase family-interacting protein of 200 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ecbd616ba36b42ea6caa6d684913db
https://pubmed.ncbi.nlm.nih.gov/22024743
https://pubmed.ncbi.nlm.nih.gov/22024743
Publikováno v:
Molecular and cellular biology. 32(1)
Living cells are adaptive self-sustaining systems. They strictly depend on the sufficient supply of oxygen, energy, and nutrients from the outside in order to sustain their internal organization. However, as autonomous entities they are able to monit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6d9e5b56ae05c615f6408bfd2f88cf
https://pubmed.ncbi.nlm.nih.gov/22025673
https://pubmed.ncbi.nlm.nih.gov/22025673
Autor:
Thomas Iftner, Florian Paasch, Joachim Manns, Sebastian Wesselborg, Antje S. Löffler, Sebastian Alers, Alexandra M. Dieterle, Stefan Driessen, Klaus Schulze-Osthoff, Nadine Hoffmann, Björn Stork, Kirsten Lauber, Merle Daubrawa
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(9)
The protein kinase inhibitor staurosporine is one of the most potent and frequently used proapoptotic stimuli, although its mechanism of action is poorly understood. Here, we show that staurosporine as well as its analog 7-hydroxystaurosporine (UCN-0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a86e24fecef119fb1395ad6d60eb18
https://pubmed.ncbi.nlm.nih.gov/21659556
https://pubmed.ncbi.nlm.nih.gov/21659556
Autor:
Simon G. Pfisterer, Sebastian Wesselborg, Sebastian Alers, Antje Grotemeier, Benoit Viollet, Florian Paasch, Merle Daubrawa, Alexandra M. Dieterle, Björn Stork, Tassula Proikas-Cezanne
Publikováno v:
Cellular signalling. 22(6)
Autophagy is a eukaryotic lysosomal bulk degradation system initiated by cytosolic cargo sequestration in autophagosomes. The Ser/Thr kinase mTOR has been shown to constitute a central role in controlling the initiation of autophagy by integrating mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a029952abef8551bee6597202cd8a0
https://pubmed.ncbi.nlm.nih.gov/20114074
https://pubmed.ncbi.nlm.nih.gov/20114074
Autor:
Ronald Orth, Björn Stork, Sebastian Wesselborg, Antje Grotemeier, Sebastian Alers, Reiner Lammers, Susanne Ullrich, Alexandra M. Dieterle, Merle Daubrawa
Publikováno v:
International journal of cancer. 125(4)
Aberrant PI3K/Akt signaling has been implicated in many human cancers, including prostate carcinomas. Currently different therapeutic strategies target the inhibition of this survival pathway. The nucleoside analog triciribine (TCN), which was initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaf54216e4d557896df67238e1452af
https://pubmed.ncbi.nlm.nih.gov/19422047
https://pubmed.ncbi.nlm.nih.gov/19422047
Publikováno v:
Autophagy. 10:1481-1481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::181497038374f3facf10cb4fc9e4ee58
https://doi.org/10.4161/auto.29717
https://doi.org/10.4161/auto.29717