Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Sebastian A Mikolajczak"'
Autor:
Nicole L Bertschi, Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, Sven Schuierer, Florian Nigsch, Walter Carbone, Judith Knehr, Devendra K Gupta, Sam O Hofman, Nicole van der Werff, Ivonne Nieuwenhuis, Els Klooster, Bart W Faber, Erika L Flannery, Sebastian A Mikolajczak, Vorada Chuenchob, Binesh Shrestha, Martin Beibel, Tewis Bouwmeester, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Thierry T Diagana, Clemens HM Kocken, Guglielmo Roma
Publikováno v:
eLife, Vol 7 (2018)
Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery. We previously unraveled the transcriptome
Externí odkaz:
https://doaj.org/article/6d1126676c6b4f1ea54e1b0c7ad01e87
Autor:
Kristian E Swearingen, Scott E Lindner, Erika L Flannery, Ashley M Vaughan, Robert D Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L Moritz, Stefan H I Kappe, Jetsumon Sattabongkot, Sebastian A Mikolajczak
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005791 (2017)
Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases. Research efforts predominantly focus on P. falciparum because of the clinical severity of infection and associated mortality rates. However, P. vivax malaria affect
Externí odkaz:
https://doaj.org/article/3893574e7ba44319831b3cd61e68b2d9
Autor:
Gabriel Mitchell, Laura Torres, Matthew E. Fishbaugher, Melanie Lam, Vorada Chuenchob, Reena Zalpuri, Shreya Ramasubban, Caitlin N. Baxter, Erika L. Flannery, Anke Harupa, Sebastian A. Mikolajczak, Danielle M. Jorgens
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background The infection of the liver by Plasmodium parasites is an obligatory step leading to malaria disease. Following hepatocyte invasion, parasites differentiate into replicative liver stage schizonts and, in the case of Plasmodium spec
Externí odkaz:
https://doaj.org/article/913dea0f200b435c9b2339a51e0dc3fa
Autor:
Adela Nacer, Alexandru Movila, Kerstin Baer, Sebastian A Mikolajczak, Stefan H I Kappe, Ute Frevert
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002982 (2012)
Plasmodium falciparum malaria is responsible for nearly one million annual deaths worldwide. Because of the difficulty in monitoring the pathogenesis of cerebral malaria in humans, we conducted a study in various mouse models to better understand dis
Externí odkaz:
https://doaj.org/article/ff39d7fdce9d41f185422f6fd36ab36a
Autor:
Gabriel Mitchell, Guglielmo Roma, Annemarie Voorberg-van der Wel, Martin Beibel, Anne-Marie Zeeman, Sven Schuierer, Laura Torres, Erika L. Flannery, Clemens H. M. Kocken, Sebastian A. Mikolajczak, Thierry T. Diagana
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract Background The zoonotic simian parasite Plasmodium cynomolgi develops into replicating schizonts and dormant hypnozoites during the infection of hepatocytes and is used as a model organism to study relapsing malaria. The transcriptional prof
Externí odkaz:
https://doaj.org/article/0e680a8fe8ac407888ecdc3feea9dfd8
Autor:
Erika L. Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Wanlapa Roobsoong, Matthew Fishbaugher, Kevin Zhou, Zachary P. Billman, Thomas Martinson, Tayla M. Olsen, Carola Schäfer, Brice Campo, Sean C. Murphy, Sebastian A. Mikolajczak, Stefan H.I. Kappe, Jetsumon Sattabongkot
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 427-440 (2022)
Plasmodium vivax is a malaria-causing pathogen that establishes a dormant form in the liver (the hypnozoite), which can activate weeks, months, or years after the primary infection to cause a relapse, characterized by secondary blood-stage infection.
Externí odkaz:
https://doaj.org/article/3f99df60d3ce4a3b823a1cfa275feab1
Autor:
Gigliola Zanghi, Hardik Patel, Nelly Camargo, Jenny L. Smith, Yeji Bae, Erika L. Flannery, Vorada Chuenchob, Matthew E. Fishbaugher, Sebastian A Mikolajczak, Wanlapa Roobsoong, Jetsumon Sattabongkot, Kiera Hayes, Ashley M. Vaughan, Stefan H. I. Kappe
Plasmodium falciparum(Pf) is causing the greatest malaria burden, yet the liver stages (LS) of this most important parasite species have remained poorly studied. Here, we used a human liver-chimeric mouse model in combination with a novel fluorescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5700625ca3d8df880b0400fe5ee9d60
https://doi.org/10.1101/2023.01.05.522945
https://doi.org/10.1101/2023.01.05.522945
Autor:
Mélanie Pellisson, Lucy Kirchhofer-Allan, Guglielmo Roma, Matthias Mueller, Sven Schuierer, Anne-Marie Zeeman, Erika L. Flannery, Matthias Rottmann, Sebastian A. Mikolajczak, Thierry Doll, Clemens H. M. Kocken, Pascal Maeser
Plasmodium cynomolgi (Pc) is one of the few parasite species that forms quiescent liver stage parasites known as hypnozoites and is therefore a suitable model for Plasmodium vivax. Very little is known about liver stage dormancy, which hampers the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c53501278911115abce0980ba986154
https://doi.org/10.1101/2021.11.16.468833
https://doi.org/10.1101/2021.11.16.468833
Autor:
Melisa Gualdrón-López, Miriam Díaz-Varela, Gigliola Zanghi, Iris Aparici-Herraiz, Ryan W.J. Steel, Carola Schäfer, Pol Cuscó, Vorada Chuenchob, Niwat Kangwangransan, Zachary P. Billman, Tayla M. Olsen, Juan R. González, Wanlapa Roobsoong, Jetsumon Sattabongkot, Sean C. Murphy, Sebastian A. Mikolajczak, Eva Borràs, Eduard Sabidó, Carmen Fernandez-Becerra, Erika L. Flannery, Stefan H.I. Kappe, Hernando A. del Portillo
Publikováno v:
Molecular & Cellular Proteomics. 21:100406
Latent liver stages termed hypnozoites cause relapsing Plasmodium vivax malaria infection and represent a major obstacle in the goal of malaria elimination. Hypnozoites are clinically undetectable, and presently, there are no biomarkers of this persi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b45c9c9d46c0502bbdf6f74b7dfa99e
https://doi.org/10.1016/j.mcpro.2022.100406
https://doi.org/10.1016/j.mcpro.2022.100406
Autor:
Carola Schäfer, Olesya Trakhimets, Nicholas Dambrauskas, Laura M. Reynolds, Jetsumon Sattabongkot, Stefan H. I. Kappe, Sebastian A. Mikolajczak, Andrew Raappana, D. Noah Sather, Erika L. Flannery, Wanlapa Roobsoong
Publikováno v:
Cell hostmicrobe. 29(5)
Summary Latent forms of Plasmodium vivax, called hypnozoites, cause malaria relapses from the liver into the bloodstream and are a major obstacle to malaria eradication. To experimentally assess the impact of a partially protective pre-erythrocytic v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b911b301b607efb482f047687d52e7
https://pubmed.ncbi.nlm.nih.gov/33857426
https://pubmed.ncbi.nlm.nih.gov/33857426