A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection

Autor: Jesus Augusto Vazquez-Rodriguez, Bahaa Shaqour, Clara Guarch-Pérez, Emilia Choińska, Martijn Riool, Bart Verleije, Koen Beyers, Vivian J. A. Costantini, Wojciech Święszkowski, Sebastian A. J. Zaat, Paul Cos, Antonio Felici, Livia Ferrari

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract Biomaterial-associated infections are a major healthcare challenge as they are responsible for high disease burden in critically ill patients. In this study, we have developed drug-eluting antibacterial catheters to prevent catheter-related

Externí odkaz: https://doaj.org/article/063a964a93684d7aa1e518dfdf52a798

CalcAMP: A New Machine Learning Model for the Accurate Prediction of Antimicrobial Activity of Peptides

Autor: Colin Bournez, Martijn Riool, Leonie de Boer, Robert A. Cordfunke, Leonie de Best, Remko van Leeuwen, Jan Wouter Drijfhout, Sebastian A. J. Zaat, Gerard J. P. van Westen

Publikováno v: Antibiotics, Vol 12, Iss 4, p 725 (2023)

To combat infection by microorganisms host organisms possess a primary arsenal via the innate immune system. Among them are defense peptides with the ability to target a wide range of pathogenic organisms, including bacteria, viruses, parasites, and

Externí odkaz: https://doaj.org/article/bba35ed07cc441348c3987da0c9147cf

3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Staphylococcus aureus Infection in Mice

Autor: Clara Guarch-Pérez, Bahaa Shaqour, Martijn Riool, Bart Verleije, Koen Beyers, Chris Vervaet, Paul Cos, Sebastian A. J. Zaat

Publikováno v: Pharmaceutics, Vol 14, Iss 7, p 1363 (2022)

Bacterial infections are a serious healthcare complication in orthopedic and trauma surgery worldwide. Compared to systemic, local antibiotic prophylaxis has been shown to provide a higher antibiotic dose and bioavailability at the bone site with min

Externí odkaz: https://doaj.org/article/0f8403bf84c64581addac0cc0ad3ad34

CalcAMP

Autor: Colin Bournez, Martijn Riool, Leonie de Boer, Robert A. Cordfunke, Leonie de Best, Remko van Leeuwen, Jan Wouter Drijfhout, Sebastian A. J. Zaat, Gerard J. P. van Westen

Publikováno v: Antibiotics; Volume 12; Issue 4; Pages: 725
Antibiotics, 12(4):725
Antibiotics, 12(4):725. Multidisciplinary Digital Publishing Institute (MDPI)

To combat infection by microorganisms host organisms possess a primary arsenal via the innate immune system. Among them are defense peptides with the ability to target a wide range of pathogenic organisms, including bacteria, viruses, parasites, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc8bc37eb251bc4d3bda010ce4400bf
https://hdl.handle.net/1887/3618249

Development of an Antimicrobial Peptide SAAP-148-Functionalized Supramolecular Coating on Titanium to Prevent Biomaterial-Associated Infections

Autor: Moniek G. J. Schmitz, Martijn Riool, Leonie de Boer, Annika F. Vrehen, Paul A. A. Bartels, Sebastian A. J. Zaat, Patricia Y. W. Dankers

Publikováno v: Advanced Materials Technologies. Wiley-Blackwell

Titanium implants are widely used in medicine but have a risk of biomaterial-associated infection (BAI), of which traditional antibiotic-based treatment is affected by resistance. Antimicrobial peptides (AMPs) are used to successfully kill antibiotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc60db3fcb594df9497edf3c73837f68
https://pure.amc.nl/en/publications/development-of-an-antimicrobial-peptide-saap148functionalized-supramolecular-coating-on-titanium-to-prevent-biomaterialassociated-infections(6f4dfe9f-34c7-41a1-bb8c-fe712adc6f62).html