Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Sebastian A, Mikolajczak"'
Autor:
Gabriel Mitchell, Laura Torres, Matthew E. Fishbaugher, Melanie Lam, Vorada Chuenchob, Reena Zalpuri, Shreya Ramasubban, Caitlin N. Baxter, Erika L. Flannery, Anke Harupa, Sebastian A. Mikolajczak, Danielle M. Jorgens
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background The infection of the liver by Plasmodium parasites is an obligatory step leading to malaria disease. Following hepatocyte invasion, parasites differentiate into replicative liver stage schizonts and, in the case of Plasmodium spec
Externí odkaz:
https://doaj.org/article/913dea0f200b435c9b2339a51e0dc3fa
Autor:
Gabriel Mitchell, Guglielmo Roma, Annemarie Voorberg-van der Wel, Martin Beibel, Anne-Marie Zeeman, Sven Schuierer, Laura Torres, Erika L. Flannery, Clemens H. M. Kocken, Sebastian A. Mikolajczak, Thierry T. Diagana
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract Background The zoonotic simian parasite Plasmodium cynomolgi develops into replicating schizonts and dormant hypnozoites during the infection of hepatocytes and is used as a model organism to study relapsing malaria. The transcriptional prof
Externí odkaz:
https://doaj.org/article/0e680a8fe8ac407888ecdc3feea9dfd8
Autor:
Erika L. Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Wanlapa Roobsoong, Matthew Fishbaugher, Kevin Zhou, Zachary P. Billman, Thomas Martinson, Tayla M. Olsen, Carola Schäfer, Brice Campo, Sean C. Murphy, Sebastian A. Mikolajczak, Stefan H.I. Kappe, Jetsumon Sattabongkot
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 427-440 (2022)
Plasmodium vivax is a malaria-causing pathogen that establishes a dormant form in the liver (the hypnozoite), which can activate weeks, months, or years after the primary infection to cause a relapse, characterized by secondary blood-stage infection.
Externí odkaz:
https://doaj.org/article/3f99df60d3ce4a3b823a1cfa275feab1
Autor:
Carola Schäfer, Wanlapa Roobsoong, Niwat Kangwanrangsan, Martino Bardelli, Thomas A. Rawlinson, Nicholas Dambrauskas, Olesya Trakhimets, Chaitra Parthiban, Debashree Goswami, Laura M. Reynolds, Spencer Y. Kennedy, Erika L. Flannery, Sean C. Murphy, D. Noah Sather, Simon J. Draper, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, Stefan H.I. Kappe
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101381- (2020)
Summary: The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to the lack of suitable laboratory models. Here, we report a humanized mouse model to test interventions that block P. vivax parasite transition from liver s
Externí odkaz:
https://doaj.org/article/539baa8ec6b04adda354f129f8d342b9
Autor:
Carola Schafer, Nicholas Dambrauskas, Ryan W. Steel, Sara Carbonetti, Vorada Chuenchob, Erika L. Flannery, Vladimir Vigdorovich, Brian G. Oliver, Wanlapa Roobsoong, Steven P. Maher, Dennis Kyle, Jetsumon Sattabongkot, Stefan H. I. Kappe, Sebastian A. Mikolajczak, D. Noah Sather
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract Background Plasmodium vivax is the most geographically widespread of the human malaria parasites, causing 50,000 to 100,000 deaths annually. Plasmodium vivax parasites have the unique feature of forming dormant liver stages (hypnozoites) tha
Externí odkaz:
https://doaj.org/article/50d4e920d50749a48c3b9346d940940a
Autor:
Alison Roth, Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson-Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H. I. Kappe, David E. Lanar, François Nosten, Silas Davidson, Rays H. Y. Jiang, Dennis E. Kyle, John H. Adams
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug
Externí odkaz:
https://doaj.org/article/0b14f6d533014ef091394f171d42ba23
Autor:
Gigliola Zanghi, Hardik Patel, Nelly Camargo, Jenny L. Smith, Yeji Bae, Erika L. Flannery, Vorada Chuenchob, Matthew E. Fishbaugher, Sebastian A Mikolajczak, Wanlapa Roobsoong, Jetsumon Sattabongkot, Kiera Hayes, Ashley M. Vaughan, Stefan H. I. Kappe
Plasmodium falciparum(Pf) is causing the greatest malaria burden, yet the liver stages (LS) of this most important parasite species have remained poorly studied. Here, we used a human liver-chimeric mouse model in combination with a novel fluorescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5700625ca3d8df880b0400fe5ee9d60
https://doi.org/10.1101/2023.01.05.522945
https://doi.org/10.1101/2023.01.05.522945
Autor:
Nicole L Bertschi, Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, Sven Schuierer, Florian Nigsch, Walter Carbone, Judith Knehr, Devendra K Gupta, Sam O Hofman, Nicole van der Werff, Ivonne Nieuwenhuis, Els Klooster, Bart W Faber, Erika L Flannery, Sebastian A Mikolajczak, Vorada Chuenchob, Binesh Shrestha, Martin Beibel, Tewis Bouwmeester, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Thierry T Diagana, Clemens HM Kocken, Guglielmo Roma
Publikováno v:
eLife, Vol 7 (2018)
Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery. We previously unraveled the transcriptome
Externí odkaz:
https://doaj.org/article/6d1126676c6b4f1ea54e1b0c7ad01e87
Autor:
Melisa Gualdrón-López, Erika L. Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Dietmar Fernandez-Orth, Joan Segui-Barber, Felix Royo, Juan M. Falcón-Pérez, Carmen Fernandez-Becerra, Marcus V. G. Lacerda, Stefan H. I. Kappe, Jetsumon Sattabongkot, Juan R. Gonzalez, Sebastian A. Mikolajczak, Hernando A. del Portillo
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Exosomes are extracellular vesicles of endocytic origin containing molecular signatures implying the cell of origin; thus, they offer a unique opportunity to discover biomarkers of disease. Plasmodium vivax, responsible for more than half of all mala
Externí odkaz:
https://doaj.org/article/580a4f327ad84defa1f7c6e360dd02f1
Autor:
Lander Foquet, Carola Schafer, Nana K. Minkah, Daniel G. W. Alanine, Erika L. Flannery, Ryan W. J. Steel, Brandon K. Sack, Nelly Camargo, Matthew Fishbaugher, Will Betz, Thao Nguyen, Zachary P. Billman, Elizabeth M. Wilson, John Bial, Sean C. Murphy, Simon J. Draper, Sebastian A. Mikolajczak, Stefan H. I. Kappe
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of Plasmodium falciparum. In contrast, the current models to directly study blood stage infection in vivo are extremely limited. Humanizat
Externí odkaz:
https://doaj.org/article/c64469f54c4448cfa0dcb7e11dccc724