Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sebastian, Werneburg"'
Autor:
Radhika Joshi, Veronika Brezani, Gabrielle M. Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szabo
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficien
Externí odkaz:
https://doaj.org/article/a6777c870b7d4b4d97a8c4e5b7383a1a
Publikováno v:
Stem Cell Research, Vol 14, Iss 3, Pp 339-346 (2015)
Oligodendrocyte precursor cells (OPCs) are the progenitors of myelinating oligodendrocytes in brain development and repair. Successful myelination depends on the control of adhesiveness during OPC migration and axon contact formation. The decoration
Externí odkaz:
https://doaj.org/article/3382f1f3cac64472987a855d5ea7b7b9
Autor:
Matthieu Moisse, Daphna Rothschild, Kevin P. Kenna, Tsviya Olender, Eran Segal, Aleksey Shatunov, Elik Chapnik, Elad Barkan, Sebastian Werneburg, Alfredo Iacoangeli, Justin K. Ichida, Pamela J. Shaw, Ammar Al-Chalabi, Farhan Smk, Dorothy P. Schafer, Eran Hornstein, Omer Weissbrod, Nancy S Yacovzada, Ashley R. Jones, van Eijk Kr, William Sproviero, Van Damme P, van den Berg Lh, Jan H. Veldink, Hung S, Robert H. Brown, van der Spek Raa, Aviad Siany, Chen Eitan, Johnathan Cooper-Knock, Al Khleifat A, Hemali Phatnani
The non-coding genome is substantially larger than the protein-coding genome but is largely unexplored by genetic association studies. Here, we performed region-based burden analysis of >25,000 variants in untranslated regions of 6,139 amyotrophic la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7694d3e8d29fe3d56d03a5d31951adc3
https://doi.org/10.1101/2021.06.03.446863
https://doi.org/10.1101/2021.06.03.446863
Autor:
Chen, Eitan, Aviad, Siany, Elad, Barkan, Tsviya, Olender, Kristel R, van Eijk, Matthieu, Moisse, Sali M K, Farhan, Yehuda M, Danino, Eran, Yanowski, Hagai, Marmor-Kollet, Natalia, Rivkin, Nancy Sarah, Yacovzada, Shu-Ting, Hung, Johnathan, Cooper-Knock, Chien-Hsiung, Yu, Cynthia, Louis, Seth L, Masters, Kevin P, Kenna, Rick A A, van der Spek, William, Sproviero, Ahmad, Al Khleifat, Alfredo, Iacoangeli, Aleksey, Shatunov, Ashley R, Jones, Yael, Elbaz-Alon, Yahel, Cohen, Elik, Chapnik, Daphna, Rothschild, Omer, Weissbrod, Gilad, Beck, Elena, Ainbinder, Shifra, Ben-Dor, Sebastian, Werneburg, Dorothy P, Schafer, Robert H, Brown, Pamela J, Shaw, Philip, Van Damme, Leonard H, van den Berg, Hemali, Phatnani, Eran, Segal, Justin K, Ichida, Ammar, Al-Chalabi, Jan H, Veldink, Eran, Hornstein
Publikováno v:
Nature neuroscience. 25(4)
The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of25,000 variants in untranslated regions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc9e56b786ebabba09c3e4ae6a7ecb6d
https://pubmed.ncbi.nlm.nih.gov/35361972
https://pubmed.ncbi.nlm.nih.gov/35361972
Publikováno v:
Current Opinion in Neurobiology. 47:138-145
Microglia have recently been recognized as key regulators of synapse development, function, and plasticity. Critical to progressing the field is the identification of molecular underpinnings necessary for microglia to carry out these important functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d0bacc3aed451ca785b0705ad53417
https://doi.org/10.1016/j.conb.2017.10.002
https://doi.org/10.1016/j.conb.2017.10.002
Autor:
Sebastian Werneburg, Jonathan Jung, Stephen J. Crocker, Nicholas J. Luciano, Daniel S. Reich, Brian Popko, Dorothy P. Schafer, Guangping Gao, Rejani B. Kunjamma, Seung Kwon Ha, Cory M. Willis
SummaryMultiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes. Here, in striking similarity to other neurodegenerative diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c1b91b3aba026dccec6ba6ce884dc1
Autor:
Maike Steindel, Dorothy P. Schafer, Omer Ali Bayraktar, Jan Broder Engler, Dmitry Velmeshev, Lawrence R. Shiow, Aparna Bhaduri, Richard Reynolds, David H. Rowitch, John H. Stockley, Maximilian Haeussler, Max Kaufmann, Brian Tung, Nitasha Goyal, Stephanie Vistnes, Arnold R. Kriegstein, Robin J.M. Franklin, Diane Jung, Manuel A. Friese, Simone Mayer, Sebastian Werneburg, Staffan Holmqvist, Lucas Schirmer, Adam Young
Publikováno v:
Nature, vol 573, iss 7772
Nature
Nature
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing-remitting disease course at early stages, distinct lesion characteristics in cortical grey versus subcortical white matter and neurodegeneration at chronic stages. Here we used s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340b3c64f631133e1768fea137d0d953
https://escholarship.org/uc/item/3zw1916g
https://escholarship.org/uc/item/3zw1916g
Autor:
Nikola Brozko, Marta B. Wisniewska, L Szewczyk, Herbert Hildebrandt, Iris Röckle, Sebastian Werneburg, Andrzej Nagalski, Jacek Kuznicki
Publikováno v:
Glia. 65:34-49
ST8SIA2 is a polysialyltransferase that attaches polysialic acid to the glycoproteins NCAM1 and CADM1. Polysialylation is involved in brain development and plasticity. ST8SIA2 is a schizophrenia candidate gene, and St8sia2-/- mice exhibit schizophren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb0ac0855bf28c653f0b579c5bbde08b
https://doi.org/10.1002/glia.23048
https://doi.org/10.1002/glia.23048
Autor:
Herbert Hildebrandt, Harald Neumann, Falk F. R. Buettner, Mona Mathews, Sebastian Werneburg, Martina Mühlenhoff, Larissa Erben
Publikováno v:
Glia. 64:1314-1330
Microglia are tissue macrophages and mediators of innate immune responses in the brain. The protein-modifying glycan polysialic acid (polySia) is implicated in modulating microglia activity. Cultured murine microglia maintain a pool of Golgi-confined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cc87b9e61c03267d91e22b0c46bcb07
https://doi.org/10.1002/glia.23004
https://doi.org/10.1002/glia.23004