Zobrazeno 1 - 10
of 483
pro vyhledávání: '"Sebastian, Stintzing"'
Autor:
Abdelhadi Boulifa, Martin J. Raftery, Alexander Sebastian Franzén, Clarissa Radecke, Sebastian Stintzing, Jens-Uwe Blohmer, Gabriele Pecher
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Beta-(1,3)(1,6)-D-glucan is a complex polysaccharide, which is found in the cell wall of various fungi, yeasts, bacteria, algae, barley, and oats and has immunomodulatory, anticancer and antiviral effects. In the present study, we
Externí odkaz:
https://doaj.org/article/6fd8548e041f4b07ba2f2ba4a7de30ca
Autor:
Alexander J. Ohnmacht, Arndt Stahler, Sebastian Stintzing, Dominik P. Modest, Julian W. Holch, C. Benedikt Westphalen, Linus Hölzel, Marisa K. Schübel, Ana Galhoz, Ali Farnoud, Minhaz Ud-Dean, Ursula Vehling-Kaiser, Thomas Decker, Markus Moehler, Matthias Heinig, Volker Heinemann, Michael P. Menden
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Precision medicine has revolutionised cancer treatments; however, actionable biomarkers remain scarce. To address this, we develop the Oncology Biomarker Discovery (OncoBird) framework for analysing the molecular and biomarker landscape of r
Externí odkaz:
https://doaj.org/article/6154ff20ebe74724a6a6c7ebb50722a3
Autor:
Nina Winkelmann, Michaela Schwarz, Bert Hildebrandt, Oliver Henke, Lars Bullinger, Il‐Kang Na, Sebastian Stintzing, Philipp le Coutre
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 949-953 (2022)
Abstract In this analysis, we examined the risk of secondary malignancies for tyrosine kinase inhibitor (TKI) therapy in chronic myeloid leukemia (CML) patients. We also collected data on specific risk factors for colorectal cancer. Ninety‐one pati
Externí odkaz:
https://doaj.org/article/54f065c65b1b4468aa13636b34af3f54
Autor:
Jingyuan Wang, Joshua Millstein, Yan Yang, Sebastian Stintzing, Hiroyuki Arai, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Christoph Mancao, Chiara Cremolini, Tianshu Liu, Volker Heinemann, Alfredo Falcone, Lin Shen, Heinz-Josef Lenz
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101827- (2023)
Summary: Background: Antiangiogenic drug (AAD)-triggered oxygen and nutrient depletion through suppression of angiogenesis switches glucose-dependent to lipid-dependent metabolism. Blocking fatty acid oxidation can enhance AAD-mediated anti-tumor eff
Externí odkaz:
https://doaj.org/article/369c666a028b48c587ea629fca3a1f39
Autor:
Nathanael Raschzok, Sebastian Stintzing, Volker Heinemann, Geraldine Rauch, Jens Ricke, Matthias Guckenberger, Annika Kurreck, Annabel H. S. Alig, Arndt Stahler, Lars Bullinger, Moritz Schmelzle, Wenzel Schöning, Georg Lurje, Felix Krenzien, Oliver Haase, Beate Rau, Bernhard Gebauer, Igor M. Sauer, Johann Pratschke, Dominik P. Modest
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Additive/adjuvant chemotherapy as concept after local treatment of colorectal metastases has not been proven to be successful by phase III trials. Accordingly, a standard of care to improve relapse rates and long-term survival is
Externí odkaz:
https://doaj.org/article/55d7920af6364e2ab185a5a9e624c46b
Autor:
Chiara Cremolini, Clara Montagut, Philippe Ronga, Filippo Venturini, Kensei Yamaguchi, Sebastian Stintzing, Alberto Sobrero
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
In patients with RAS wild-type metastatic colorectal cancer (mCRC), an anti-epidermal growth factor receptor (EGFR) monoclonal antibody plus chemotherapy is a standard option for treatment in the first-line setting. Patients who progress while on tre
Externí odkaz:
https://doaj.org/article/1777e610457b4d03857d820d434f40e8
Autor:
Deepak Vangala, Swetlana Ladigan, Sven T. Liffers, Soha Noseir, Abdelouahid Maghnouj, Tina-Maria Götze, Berlinda Verdoodt, Susanne Klein-Scory, Laura Godfrey, Martina K. Zowada, Mario Huerta, Daniel L. Edelstein, Jaime Martinez de Villarreal, Miriam Marqués, Jörg Kumbrink, Andreas Jung, Tobias Schiergens, Jens Werner, Volker Heinemann, Sebastian Stintzing, Doris Lindoerfer, Ulrich Mansmann, Michael Pohl, Christian Teschendorf, Christiane Bernhardt, Heiner Wolters, Josef Stern, Selami Usta, Richard Viebahn, Jacob Admard, Nicolas Casadei, Stefan Fröhling, Claudia R. Ball, Jens T. Siveke, Hanno Glimm, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-25 (2021)
Abstract Background The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully understood at the molecular level. Here we tested in vivo s
Externí odkaz:
https://doaj.org/article/cfb1d471a175414a977bd791dd7bb74a
Autor:
Madiha Naseem, Shu Cao, Dongyun Yang, Joshua Millstein, Alberto Puccini, Fotios Loupakis, Sebastian Stintzing, Chiara Cremolini, Ryuma Tokunaga, Francesca Battaglin, Shivani Soni, Martin D. Berger, Afsaneh Barzi, Wu Zhang, Alfredo Falcone, Volker Heinemann, Heinz-Josef Lenz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract KRAS status serves as a predictive biomarker of response to treatment in metastatic colorectal cancer (mCRC). We hypothesize that complex interactions between multiple pathways contribute to prognostic differences between KRAS wild-type and
Externí odkaz:
https://doaj.org/article/bcef797c1a0241b78b98c0ecbb71d350
Autor:
Luise Victoria Claaß, Christoph Schultheiß, Rebekka Scholz, Lisa Paschold, Donjete Simnica, Volker Heinemann, Sebastian Stintzing, Mascha Binder
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The two most common antibody targeting principles in oncology are the induction of direct antitumor effects and the release of antitumor T cell immunity by immune checkpoint blockade. These two principles, however, may be overlapping if the targeted
Externí odkaz:
https://doaj.org/article/2d6370d424ab4af9b1f101acb1e6819d
Autor:
Laura E. Fischer, Sebastian Stintzing, Volker Heinemann, Ulrich Keilholz, Dietmar Keune, Claudia Vollbrecht, Thomas Burmeister, Andreas Kind, Lena Weiss, David Horst, Thomas Kirchner, Frederick Klauschen, Andreas Jung, Christoph Benedikt Westphalen, Ivan Jelas
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectivesThe use of liquid biopsies (LB) in patients with solid malignancies enables comprehensive genomic profiling (CGP) of circulating tumor DNA (ctDNA) and has the potential to guide therapy stratification and support disease monitoring. To exam
Externí odkaz:
https://doaj.org/article/965735d49d9549379321a45c09777ab9