Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Sebastian, Carotta"'
Autor:
Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106381- (2023)
Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties. Th
Externí odkaz:
https://doaj.org/article/68266ad8652247818e6f91fc5012f708
Autor:
Jesse J. Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Müller, Sabina Berezowska, Patrick Dorn, Thomas M. Marti, Ralph A. Schmid, Belazs Hegedüs, Abdallah Souabni, Sebastian Carotta, Mark A. Pearson, Wolfgang Sommergruber, Greg J. Kocher, Sean R.R. Hall
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Antibody-mediated cancer immunotherapy targets inhibitory surface molecules, such as PD1, PD-L1, and CTLA-4, aiming to re-invigorate dysfunctional T cells. We purified and characterized tumor-infiltrating lymphocytes (TILs) and their patient-matched
Externí odkaz:
https://doaj.org/article/9667d060bac747349286c601bb989662
Autor:
Katrin Fischer, Roland Tschismarov, Andreas Pilz, Susy Straubinger, Sebastian Carotta, Andrew McDowell, Thomas Decker
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cutibacterium (previously Propionibacterium) acnes is an anaerobic, Gram-positive commensal of the human body. The bacterium has been associated with a variety of diseases, including acne vulgaris, prosthetic joint infections, prostate cancer, and sa
Externí odkaz:
https://doaj.org/article/6b91f7d7e80e4c39a5e9c6b9276d55bd
Autor:
Nadine Teichweyde, Lara Kasperidus, Sebastian Carotta, Valerie Kouskoff, Georges Lacaud, Peter A. Horn, Stefan Heinrichs, Hannes Klump
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 875-889 (2018)
Summary: Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4. T
Externí odkaz:
https://doaj.org/article/0cc8fcfdcd024a1ea70266de08fac1d3
Autor:
Jürgen Moll, Natarajan Muthusamy, Norbert Kraut, Darryl B. McConnell, Mark Pearson, Segundo Gonzalez, Peter Ettmayer, Sumithira Vasu, Swagata Goswami, Girish Rajgolikar, Michael P. Sanderson, Thomas Gerstberger, Renate Schnitzer, Andreas Zoephel, Heribert Arnhof, Dirk Scharn, Jark Böttcher, Seila Lorenzo-Herrero, Marc Kerenyi, Sebastian Carotta, Maria A. Impagnatiello, Harald Engelhardt, Rajeswaran Mani, Marco H. Hofmann
Supplementary Data including Table S1-Table S5 and Figure S1 - Figure S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d553495bd4441df245e0ecc2903f83f
https://doi.org/10.1158/1535-7163.22520835
https://doi.org/10.1158/1535-7163.22520835
Autor:
Jürgen Moll, Natarajan Muthusamy, Norbert Kraut, Darryl B. McConnell, Mark Pearson, Segundo Gonzalez, Peter Ettmayer, Sumithira Vasu, Swagata Goswami, Girish Rajgolikar, Michael P. Sanderson, Thomas Gerstberger, Renate Schnitzer, Andreas Zoephel, Heribert Arnhof, Dirk Scharn, Jark Böttcher, Seila Lorenzo-Herrero, Marc Kerenyi, Sebastian Carotta, Maria A. Impagnatiello, Harald Engelhardt, Rajeswaran Mani, Marco H. Hofmann
Natural killer (NK) cells play a pivotal role in controlling cancer. Multiple extracellular receptors and internal signaling nodes tightly regulate NK activation. Cyclin-dependent kinases of the mediator complex (CDK8 and CDK19) were described as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7267496a9a3dfd136c6ecb06ec5a6826
https://doi.org/10.1158/1535-7163.c.6542802.v1
https://doi.org/10.1158/1535-7163.c.6542802.v1
Autor:
Cyril Seillet, Lisa A. Mielke, Daniela B. Amann-Zalcenstein, Shian Su, Jerry Gao, Francisca F. Almeida, Wei Shi, Matthew E. Ritchie, Shalin H. Naik, Nicholas D. Huntington, Sebastian Carotta, Gabrielle T. Belz
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 436-447 (2016)
Innate lymphoid cells (ILCs) are enriched at mucosal surfaces, where they provide immune surveillance. All ILC subsets develop from a common progenitor that gives rise to pre-committed progenitors for each of the ILC lineages. Currently, the temporal
Externí odkaz:
https://doaj.org/article/47142904a3f54a61bc57324661408c07
Autor:
Swee Heng Milon Pang, Carolyn A. de Graaf, Douglas J. Hilton, Nicholas D. Huntington, Sebastian Carotta, Li Wu, Stephen L. Nutt
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. Due to this essential role and the importance of PU.1 in regulating several signature markers of lymphoid progenitors, its precise function in early l
Externí odkaz:
https://doaj.org/article/b714f5dfc2de4602a304a76bc553e9c0
Autor:
James S. Wilmott, David Hoffmann, Richard A. Scolyer, Anais Elewaut, Kevin J. Harrington, Harriet Witthock, Johannes Zuber, Christian Umkehrer, Olivier Michielin, Maria Novatchkova, Tobias Neumann, Lukas Leiendecker, Sebastian Carotta, Thomas Wiesner, Sakari Vanharanta, Georgina V. Long, Anna C. Obenauf, Izabela Krecioch, Ines Pires da Silva, Camille L. Gerard, Lisa Haas, Michel A. Cuendet, Malin Pedersen, Mario Kuttke
Publikováno v:
Nature Cancer. 2:693-708
How targeted therapies and immunotherapies shape tumors, and thereby influence subsequent therapeutic responses, is poorly understood. In the present study, we show, in melanoma patients and mouse models, that when tumors relapse after targeted thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa35d79b5fecd0bb59068e383a0c837
https://doi.org/10.1038/s43018-021-00221-9
https://doi.org/10.1038/s43018-021-00221-9
Autor:
Segundo Gonzalez, Dirk Scharn, Mark Pearson, Sebastian Carotta, Swagata Goswami, Natarajan Muthusamy, Heribert Arnhof, Sumithira Vasu, Norbert Kraut, Seila Lorenzo-Herrero, Harald Engelhardt, Michael P. Sanderson, Marc Kerenyi, Maria Antonietta Impagnatiello, Rajeswaran Mani, Renate Schnitzer, Jark Böttcher, Peter Ettmayer, Girish Rajgolikar, Marco H. Hofmann, Jürgen Moll, Andreas Zoephel, Darryl B. McConnell, Thomas Gerstberger
Publikováno v:
Mol Cancer Ther
Natural killer (NK) cells play a pivotal role in controlling cancer. Multiple extracellular receptors and internal signaling nodes tightly regulate NK activation. Cyclin-dependent kinases of the mediator complex (CDK8 and CDK19) were described as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaac64dc345ae1363e27768a9e757d9
https://doi.org/10.1158/1535-7163.mct-19-0789
https://doi.org/10.1158/1535-7163.mct-19-0789