Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sebastian, Bossert"'
Autor:
Toby M. Maher, Christina Schlecker, Doreen Luedtke, Sebastian Bossert, Donald F. Zoz, Armin Schultz
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Introduction BI 1015550 is a phosphodiesterase 4 (PDE4) inhibitor that has antifibrotic properties. Phase I and Ic studies were conducted to investigate the safety, tolerability and pharmacokinetics of BI 1015550 in healthy male subjects and patients
Externí odkaz:
https://doaj.org/article/21b9b0816508498c90339a882a036afe
Autor:
Marilisa Konietzke, Simon M. F. Triphan, Monika Eichinger, Sebastian Bossert, Hartmut Heller, Sabine Wege, Ralf Eberhardt, Michael U. Puderbach, Hans-Ulrich Kauczor, Gudula Heußel, Claus P. Heußel, Frank Risse, Mark O. Wielpütz
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) allows the assessment of pulmonary perfusion, which may play a key role in the development of muco-obstructive lung disease. One problem with quantifying pulmonary perfusion is
Externí odkaz:
https://doaj.org/article/1ca8b4993189489d94245dcd273b73f9
Autor:
Toby M, Maher, Christina, Schlecker, Doreen, Luedtke, Sebastian, Bossert, Donald F, Zoz, Armin, Schultz
IntroductionBI 1015550 is a phosphodiesterase 4 (PDE4) inhibitor that has antifibrotic properties. Phase I and Ic studies were conducted to investigate the safety, tolerability and pharmacokinetics of BI 1015550 in healthy male subjects and patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc33ee0552be7587e3a47357d3f4ec9
http://hdl.handle.net/10044/1/100466
http://hdl.handle.net/10044/1/100466
Publikováno v:
Pharmaceutical statisticsREFERENCES. 21(3)
Multiple comparison procedures and modeling (MCPMod) has established itself as a method for dose-finding under model uncertainty. A downside of MCPMod is that due to its frequentist nature in particular with respect to the multiple comparison part it
Autor:
Sebastian Bossert, Peter Pfaffelhuber
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/739e6c3130e54038a272812a1ab8ceae
Autor:
Christian Thoma, James G. Krueger, Patrick Baum, Benjamin Lang, Janine Roy, Sebastian Bossert, Hervé Bachelez, Robert Bissonnette, Sandra Garcet, Sudha Visvanathan, Ramona Schmid
Publikováno v:
The Journal of allergy and clinical immunology. 149(4)
Background The IL-36 pathway plays a key role in the pathogenesis of generalized pustular psoriasis (GPP). In a proof-of-concept clinical trial, treatment with spesolimab, an anti-IL-36 receptor antibody, resulted in rapid skin and pustular clearance
Autor:
Sebastian Bossert, Peter Pfaffelhuber
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81738 (2013)
In the area of evolutionary theory, a key question is which portions of the genome of a species are targets of natural selection. Genetic hitchhiking is a theoretical concept that has helped to identify various such targets in natural populations. In
Externí odkaz:
https://doaj.org/article/c67237c89a284fb38f9d801e63db404d
Autor:
Peter Pfaffelhuber, Sebastian Bossert
For a highly beneficial mutant $A$ entering a randomly reproducing population of constant size, we study the situation when a second beneficial mutant $B$ arises before $A$ has fixed. If the selection coefficient of $B$ is greater than the selection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d0757b5f3647b6ef434d0d26263fde
http://arxiv.org/abs/1610.06613
http://arxiv.org/abs/1610.06613
Autor:
Sebastian Bossert, Peter Pfaffelhuber
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 1 (2014)
PLoS ONE, Vol 9, Iss 1 (2014)
This article was republished on January 17th, 2014 to include a document containing the Supporting Information for the article that was incorrectly omitted from the original edition of the article. The original edition of the article is available her