Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sebastiaan P. van Kessel"'
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms through which drug–microbiota interactions occur are still obscure. Previously, we reported that tyrosine de
Externí odkaz:
https://doaj.org/article/0e431291b2654d0aa0852d1e827ffd3c
Autor:
Sebastiaan P. van Kessel, Hiltje R. de Jong, Simon L. Winkel, Sander S. van Leeuwen, Sieger A. Nelemans, Hjalmar Permentier, Ali Keshavarzian, Sahar El Aidy
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the
Externí odkaz:
https://doaj.org/article/5c0cd6a2d67849819e3d923f5a7b5f24
Publikováno v:
mSystems, Vol 7, Iss 1 (2022)
ABSTRACT Parkinson’s disease (PD) is known to be associated with altered gastrointestinal function and microbiota composition. To date, the effect of PD medication on the gastrointestinal function and microbiota, at the site of drug absorption, the
Externí odkaz:
https://doaj.org/article/8fc8b706f0b045cd85edb1facff8cb42
Autor:
Sebastiaan P. van Kessel, Alexandra K. Frye, Ahmed O. El-Gendy, Maria Castejon, Ali Keshavarzian, Gertjan van Dijk, Sahar El Aidy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The gut microbiota can impact the bioavailability of therapeutic drugs. Here, the authors show that bacterial tyrosine decarboxylases (TDC) decrease the levels of levodopa, the primary treatment in Parkinson’s disease, by conversion to dopamine, an
Externí odkaz:
https://doaj.org/article/b417af8f89cb4dab815828a72e3ff5dd
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Parkinson's disease is the second-most common neurodegenerative disorder worldwide. Besides deciphering the mechanisms that underlie the etiology of the disease, it is important to elucidate the factors that influence the efficacy of the treatment th
Externí odkaz:
https://doaj.org/article/1e44c1c9d75c4a558c407cecd0f718ff
Autor:
Xue Liu, Clement Gallay, Morten Kjos, Arnau Domenech, Jelle Slager, Sebastiaan P van Kessel, Kèvin Knoops, Robin A Sorg, Jing‐Ren Zhang, Jan‐Willem Veening
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 5, Pp 1-18 (2017)
Abstract Genome‐wide screens have discovered a large set of essential genes in the opportunistic human pathogen Streptococcus pneumoniae. However, the functions of many essential genes are still unknown, hampering vaccine development and drug disco
Externí odkaz:
https://doaj.org/article/482825ddf1e3487fb3febf676c977939
Parkinson's disease (PD) is known to be associated with altered gastrointestinal function and microbiota composition. Altered gastrointestinal function is key in the development of small intestinal bacterial overgrowth, which is a comorbidity often o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3abaefb573b81e2227639617832b90c2
https://doi.org/10.1101/2021.07.19.452878
https://doi.org/10.1101/2021.07.19.452878
Autor:
Ahmed O. El-Gendy, Sebastiaan P van Kessel, Sahar El Aidy, Gertjan van Dijk, Maria Castejon, Ali Keshavarzian, Alexandra K. Frye
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, 10(1):310. Nature Publishing Group
Nature Communications
Nature Communications, 10(1):310. Nature Publishing Group
Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this study, we characterize gut-associated bacteria in their ability to decarboxylate levodopa to dopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccdbb782f672717d620bc6319b529bf
http://link.springer.com/article/10.1038/s41467-019-08294-y
http://link.springer.com/article/10.1038/s41467-019-08294-y
Autor:
Hiltje Riemke de Jong, Sieger Adriaan Nelemans, Ali Keshavarzian, Hjalmar P. Permentier, Sander S. van Leeuwen, Simon Laurens Winkel, Sebastiaan P van Kessel, Sahar El Aidy
Publikováno v:
BMC Biology
BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
BMC Biology, 18(1):137. BioMed Central Ltd.
BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
BMC Biology, 18(1):137. BioMed Central Ltd.
Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c19839926005ecf075a94d22c588b6d
https://doi.org/10.1186/s12915-020-00876-3
https://doi.org/10.1186/s12915-020-00876-3
Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson's Disease
Autor:
Sebastiaan P van Kessel, Sahar El Aidy
Publikováno v:
Journal of Parkinson's Disease, 9(2), S359-S370. IOS Press
Journal of Parkinson's Disease
Journal of Parkinson's Disease
Increasing evidence is supporting the hypothesis of α-synuclein pathology spreading from the gut to the brain although the exact etiology of Parkinson's disease (PD) is unknown. Furthermore, it has been proposed that inflammation, via the gastrointe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c620f7894b843e1fdd7c4a436d77f5
https://research.rug.nl/en/publications/0419772e-93ac-4a13-89c5-dfaa286f2bab
https://research.rug.nl/en/publications/0419772e-93ac-4a13-89c5-dfaa286f2bab