Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Sebastiaan J, Vastert"'
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-5 (2024)
Abstract Although the introduction of the IL-1 and IL-6 inhibiting biologics in 2012 has revolutionized the treatment and markedly improved outcomes for many patients with SJIA, about 20% of these patients continue to have active disease, have marked
Externí odkaz:
https://doaj.org/article/d5ef467d5ddc43e1a600f84c6143d7b8
Autor:
Peter A. Nigrovic, Fabrizio de Benedetti, Yukiko Kimura, Daniel J. Lovell, Sebastiaan J. Vastert
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-7 (2024)
Abstract Currently, the criteria used to classify patients with SJIA are different from those used for AOSD. However, it has been recognized that the existing terms are too narrow, subdividing the Still’s population unnecessarily between pediatric-
Externí odkaz:
https://doaj.org/article/6678de9be18f407a88a36fab07a84e7a
Autor:
Janine A. van Til, Michelle M. A. Kip, Ellen J. H. Schatorjé, Gillian Currie, Marinka Twilt, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico Wulffraat, Rae S. M. Yeung, C. G. M. (Karin) Groothuis-Oudshoorn, Sanne Warta, Deborah A. Marshall, Maarten J. IJzerman, on behalf of the UCAN CAN-DU, UCAN CURE consortia
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Objective Approximately one third of children with JIA receive biologic therapy, but evidence on biologic therapy withdrawal is lacking. This study aims to increase our understanding of whether and when pediatric rheumatologists postpone a d
Externí odkaz:
https://doaj.org/article/e8886f2cb6b24106ac37e71fabf711fd
Autor:
Lucas Wilhelmus Picavet, Anoushka A. K. Samat, Jorg Calis, Lotte Nijhuis, Rianne Scholman, Michal Mokry, David F. Tough, Rabinder K. Prinjha, Sebastiaan J. Vastert, Jorg van Loosdregt
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1344 (2024)
T cell activation is critical for an effective immune response against pathogens. However, dysregulation contributes to the pathogenesis of autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA). The molecular mechanisms underlying T cell
Externí odkaz:
https://doaj.org/article/302f5c30f18c430bb29818695732dc2e
Autor:
Lucas W. Picavet, Ellen C. N. van Vroonhoven, Rianne C. Scholman, Yesper T. H. Smits, Rupa Banerjee, Sjanna B. Besteman, Mattheus C. Viveen, Michiel M. van der Vlist, Marvin E. Tanenbaum, Robert J. Lebbink, Sebastiaan J. Vastert, Jorg van Loosdregt
Publikováno v:
Viruses, Vol 16, Iss 5, p 778 (2024)
Respiratory syncytial virus (RSV) is the most prevalent cause of acute lower respiratory infection in young children. Currently, the first RSV vaccines are approved by the FDA. Recently, N6-methyladenosine (m6A) RNA methylation has been implicated in
Externí odkaz:
https://doaj.org/article/d60fff36f6e3484aa6012a3b7d0cdb64
Autor:
Luiza R. Grazziotin, Gillian Currie, Marinka Twilt, Maarten J. IJzerman, Michelle M. A. Kip, Hendrik Koffijberg, Gouke Bonsel, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico M. Wulffraat, Rae S. M. Yeung, Wineke Armbrust, J. Merlijn van den Berg, Deborah A. Marshall
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Objective This study investigates the relationship of child, caregiver, and caring context measurements with the care-related quality of life (CRQoL) and health-related quality of life (HRQoL) of caregivers of children with juvenile idiopath
Externí odkaz:
https://doaj.org/article/41953f65f31d4feda4a954f764c7ab3b
Autor:
Luiza R. Grazziotin, Gillian Currie, Marinka Twilt, Maarten J. Ijzerman, Michelle M. A. Kip, Hendrik Koffijberg, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico M. Wulffraat, Rae S. M. Yeung, Deborah A. Marshall
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Objective Pharmacological treatment is a cornerstone of care for children with juvenile idiopathic arthritis (JIA). The objective of this study is to evaluate prescription patterns of conventional and biologic disease modifying anti-rheumati
Externí odkaz:
https://doaj.org/article/1351308fd51748cf8ddd7971b6fbf134
Autor:
Arjan Boltjes, Anoushka Ashok Kumar Samat, Maud Plantinga, Michal Mokry, Bas Castelijns, Joost F. Swart, Sebastiaan J. Vastert, Menno Creyghton, Stefan Nierkens, Jorg van Loosdregt, Femke van Wijk
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionDendritic cells (DC) are crucial for initiating and shaping immune responses. So far, little is known about the functional specialization of human DC subsets in (local) inflammatory conditions. We profiled conventional (c)DC1, cDC2 and mo
Externí odkaz:
https://doaj.org/article/a89bf43ba6e2488584442c0f47a014ee
Autor:
Ellen C. N. van Vroonhoven, Lucas W. Picavet, Rianne C. Scholman, Noortje A. M. van den Dungen, Michal Mokry, Anouk Evers, Robert J. Lebbink, Jorg J. A. Calis, Sebastiaan J. Vastert, Jorg van Loosdregt
Publikováno v:
Biology, Vol 12, Iss 7, p 1004 (2023)
T cell activation is a highly regulated process, modulated via the expression of various immune regulatory proteins including cytokines, surface receptors and co-stimulatory proteins. N6-methyladenosine (m6A) is an RNA modification that can directly
Externí odkaz:
https://doaj.org/article/e018e45d2b0a4df48705f4e586c2bf9d
Autor:
Christoph Kessel, Miha Lavric, Toni Weinhage, Markus Brueckner, Sytze de Roock, Jan Däbritz, Jakob Weber, Sebastiaan J. Vastert, Dirk Foell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Crohn's disease (CD) and ulcerative colitis (UC) have a chronic-remittent course. Optimal management of inflammatory bowel diseases (IBD) relies on early intervention, treat-to-target strategies and a tight disease control. However, it is ch
Externí odkaz:
https://doaj.org/article/37b17cb0522542b7b2404374a3412388