Zobrazeno 1 - 10
of 557
pro vyhledávání: '"Sebastiaan Engelborghs"'
Autor:
Mandy M.J. Wittens, Stijn Denissen, Diana M. Sima, Erik Fransen, Ellis Niemantsverdriet, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul de Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaëtane Picard, Annemie Ribbens, Eric Salmon, Kurt Segers, Anne Sieben, Hanne Struyfs, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Guy Nagels, Sebastiaan Engelborghs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Objectives This study aimed to evaluate the potential clinical value of a new brain age prediction model as a single interpretable variable representing the condition of our brain. Among many clinical use cases, brain age could be a novel ou
Externí odkaz:
https://doaj.org/article/31dd8603773e4eab883fb41094f7a697
Autor:
Amber Nous, Laura Seynaeve, Odile Feys, Vincent Wens, Xavier De Tiège, Pieter Van Mierlo, Amir G. Baroumand, Koenraad Nieboer, Gert-Jan Allemeersch, Shana Mangelschots, Veronique Michiels, Julie van der Zee, Christine Van Broeckhoven, Annemie Ribbens, Ruben Houbrechts, Sara De Witte, Mandy Melissa Jane Wittens, Maria Bjerke, Caroline Vanlersberghe, Sarah Ceyssens, Guy Nagels, Ilse Smolders, Sebastiaan Engelborghs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Epileptic seizures are an established comorbidity of Alzheimer’s disease (AD). Subclinical epileptiform activity (SEA) as detected by 24-h electroencephalography (EEG) or magneto-encephalography (MEG) has been reported in tempor
Externí odkaz:
https://doaj.org/article/916fefda8641476cb9b404413c08dfdd
Autor:
Lena Duchateau, Fahri Küҫükali, Arne De Roeck, Mandy M. J. Wittens, Joke Temmerman, Ilse Weets, Maarten Timmers, Sebastiaan Engelborghs, Maria Bjerke, Kristel Sleegers
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background The Alzheimer’s disease (AD) risk gene ABCA7 has suggested functions in lipid metabolism and the immune system. Rare premature termination codon (PTC) mutations and an expansion of a variable number of tandem repeats (VNTR) poly
Externí odkaz:
https://doaj.org/article/9a37017bbb464477954a0ca75a314df1
Autor:
Alexander Neumann, Olena Ohlei, Fahri Küçükali, Isabelle J. Bos, Jigyasha Timsina, Stephanie Vos, Dmitry Prokopenko, Betty M. Tijms, Ulf Andreasson, Kaj Blennow, Rik Vandenberghe, Philip Scheltens, Charlotte E. Teunissen, Sebastiaan Engelborghs, Giovanni B. Frisoni, Oliver Blin, Jill C. Richardson, Régis Bordet, Alberto Lleó, Daniel Alcolea, Julius Popp, Thomas W. Marsh, Priyanka Gorijala, Christopher Clark, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Richard J. B. Dobson, Cristina Legido-Quigley, Christine Van Broeckhoven, Rudolph E. Tanzi, Mara ten Kate, Christina M. Lill, Frederik Barkhof, Carlos Cruchaga, Simon Lovestone, Johannes Streffer, Henrik Zetterberg, Pieter Jelle Visser, Kristel Sleegers, Lars Bertram, EMIF-AD & ADNI study group
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-23 (2023)
Abstract Background Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF) biomarkers may aid in gene discovery and we previously demonstrated that si
Externí odkaz:
https://doaj.org/article/f26d48a8fac447809738ca263de2f029
Autor:
Marta del Campo, Lisa Vermunt, Carel F. W. Peeters, Anne Sieben, Yanaika S. Hok-A-Hin, Alberto Lleó, Daniel Alcolea, Mirrelijn van Nee, Sebastiaan Engelborghs, Juliette L. van Alphen, Sanaz Arezoumandan, Alice Chen-Plotkin, David J. Irwin, Wiesje M. van der Flier, Afina W. Lemstra, Charlotte E. Teunissen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. We employed proximity extension-based assays to measure 665 proteins in the cerebrospinal fluid (CSF) from patients with DLB (n =
Externí odkaz:
https://doaj.org/article/6cdb0c30f54f4ba3839a04a756e80080
Autor:
Yael Hirschberg, Natalia Valle‐Tamayo, Oriol Dols‐Icardo, Sebastiaan Engelborghs, Bart Buelens, Roosmarijn E. Vandenbroucke, Yannick Vermeiren, Kurt Boonen, Inge Mertens
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Dementia is a leading cause of death worldwide, with increasing prevalence as global life expectancy increases. The most common neurodegenerative disorders are Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease
Externí odkaz:
https://doaj.org/article/fd1aaeeff9694aa29093821377144e73
Autor:
Ioanna A. Angelidou, Marina Makri, Konrad Beyreuther, Mercè Boada Rovira, Akyllina Despoti, Sebastiaan Engelborghs, Andrea Miguel, Isabel Rodríguez, Hannah Stocker, Joke Temmerman, Magda Tsolaki, Görsev Yener, Deniz Yerlikaya, Birgit Teichmann
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Pre-symptomatic screening is getting more attention in healthcare as it detects the risk for developing neurodegenerative diseases like Alzheimer’s disease (AD), which is very useful for treatment or prevention. AD screening could pla
Externí odkaz:
https://doaj.org/article/bdc506350d474f7c9e9d853204c36933
Autor:
Patrick Cras, Vincent Van Rompaey, Joyce Bosmans, Angelique Van Ombergen, Sebastiaan Engelborghs, Annick Gilles, Julie Moyaert, Griet Mertens, Hanne Gommeren, Debby Van Dam
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Untreated hearing loss is the largest potentially modifiable risk factor for dementia. Additionally, vestibular dysfunction has been put forward as a potential risk factor for accelerated cognitive decline. Patients with Deafness Autosom
Externí odkaz:
https://doaj.org/article/7cf61ba1b8be4f2f84cdd216c8c4b041
Autor:
Maxime Vande Vyver, Louise Daeninck, Gino De Smet, Najat Aourz, Surajit Sahu, Sebastiaan Engelborghs, Kris Pauwels, Dimitri De Bundel, Ilse Smolders
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
ObjectivesEpileptiform activity and seizures are present in patients with Alzheimer’s disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ1-42) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vi
Externí odkaz:
https://doaj.org/article/a7de553c7f9c43949e643a2a8ca977d2
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Inflammatory processes are involved in the pathophysiology of both Alzheimer’s disease (AD) and multiple sclerosis (MS) but their exact contribution to disease progression remains to be deciphered. Biomarkers are needed to define pathophysiological
Externí odkaz:
https://doaj.org/article/3c4bc93f43234674933c31244eaaa5ee