Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study

Autor: Ian J. Neeland, Sebastiaan C. Boone, Dennis O. Mook‐Kanamori, Colby Ayers, Roelof A. J. Smit, Ioanna Tzoulaki, Ibrahim Karaman, Claire Boulange, Dhananjay Vaidya, Naresh Punjabi, Matthew Allison, David M. Herrington, J. Wouter Jukema, Frits R. Rosendaal, Hildo J. Lamb, Ko Willems van Dijk, Philip Greenland, Renée de Mutsert

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 9 (2019)

Background Identifying associations between serum metabolites and visceral adipose tissue (VAT) could provide novel biomarkers of VAT and insights into the pathogenesis of obesity‐related diseases. We aimed to discover and replicate metabolites ref

Externí odkaz: https://doaj.org/article/502ded21db1845dd93d04118598e9bd8

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

Autor: Froukje Vanweert, Dennis O. Mook-Kanamori, Esther Phielix, Renée de Mutsert, Patrick Schrauwen, Frits R. Rosendaal, Hildo J. Lamb, Sebastiaan C. Boone, Bram Brouwers, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling

Publikováno v: International Journal of Obesity (2005)
International Journal of Obesity, 45(7), 1510-1520. Nature Publishing Group
International Journal of Obesity, 45(7), 1510-1520. SPRINGERNATURE

Aims To evaluate whether the association between plasma branched-chain amino acids (BCAA) and intrahepatic lipid (IHL) was affected by physical activity level. Furthermore, to investigate if a conventional exercise training program, a subcategory of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3538af059bd396b288ed9974abd188f4
https://cris.maastrichtuniversity.nl/en/publications/88cbef60-bffa-4f82-9157-89462d4f8dcc

Estimated pulse wave velocity (ePWV) as a potential gatekeeper for MRI-assessed PWV

Autor: Max J P van Hout, Martin J. Schalij, Arthur J.H.A. Scholte, Hildo J. Lamb, Renée de Mutsert, Jos J.M. Westenberg, Frits R. Rosendaal, J. Wouter Jukema, Sebastiaan C. Boone, Ralph L. Widya, Ling Lin, Ilona A. Dekkers

Publikováno v: International Journal of Cardiovascular Imaging, 38, 183-193. SPRINGER

Pulse wave velocity (PWV) assessed by magnetic resonance imaging (MRI) is a prognostic marker for cardiovascular events. Prediction modelling could enable indirect PWV assessment based on clinical and anthropometric data. The aim was to calculate est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba819ee2d040c183e924e1365142e032
https://doi.org/10.1007/s10554-021-02359-0

Metabolomics: a search for biomarkers of visceral fat and liver fat content

Autor: Dennis O. Mook-Kanamori, Sebastiaan C. Boone, Albert de Roos, Ko Willems van Dijk, Saskia le Cessie, Frits R. Rosendaal, Martin den Heijer, Renée de Mutsert, Hildo J. Lamb

Publikováno v: Metabolomics, 15(10)
Boone, S, Mook-Kanamori, D, Rosendaal, F, den Heijer, M, Lamb, H, de Roos, A, le Cessie, S, Willems van Dijk, K & de Mutsert, R 2019, ' Metabolomics: a search for biomarkers of visceral fat and liver fat content ', Metabolomics : Official journal of the Metabolomic Society, vol. 15, no. 10, 139, pp. 139 . https://doi.org/10.1007/s11306-019-1599-x
Metabolomics
Metabolomics : Official journal of the Metabolomic Society, 15(10):139

Intoduction Excess visceral and liver fat are known risk factors for cardiometabolic disorders. Metabolomics might allow for easier quantification of these ectopic fat depots, instead of using invasive and costly tools such as MRI or approximations s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2281d6d652f5e4576da96ab26724ff48
https://doi.org/10.1007/s11306-019-1599-x

Avoiding selection bias in metabolomics studies: a tutorial

Autor: Dennis O. Mook-Kanamori, K. Willems van Dijk, R. de Mutsert, Sebastiaan C. Boone, S. le Cessie

Publikováno v: Metabolomics, 15(1)

Metabolomics techniques are increasingly applied in epidemiologic research. Many available assays are still relatively expensive and therefore measurements are often performed in small patient population studies such as case series or case–control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4046cf20da1b2839d1950571c2ad43bf
https://pubmed.ncbi.nlm.nih.gov/30830435