Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength

Autor: Eike K Mahlandt, Sebastián Palacios Martínez, Janine JG Arts, Simon Tol, Jaap D van Buul, Joachim Goedhart

Publikováno v: eLife, Vol 12 (2023)

The inner layer of blood vessels consists of endothelial cells, which form the physical barrier between blood and tissue. This vascular barrier is tightly regulated and is defined by cell-cell contacts through adherens and tight junctions. To investi

Externí odkaz: https://doaj.org/article/6f771142eee24d0bb49875f225b5d7e6

Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1

Autor: Max L B Grönloh, Janine J G Arts, Sebastián Palacios Martínez, Amerens A van der Veen, Lanette Kempers, Abraham C I van Steen, Joris J T H Roelofs, Martijn A Nolte, Joachim Goedhart, Jaap D van Buul

Publikováno v: Grönloh, M L B, Arts, J J G, Palacios Martínez, S, van der Veen, A A, Kempers, L, van Steen, A C I, Roelofs, J J T H, Nolte, M A, Goedhart, J & van Buul, J D 2023, ' Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1 ', EMBO Reports, vol. 24, no. 1, e55483 . https://doi.org/10.15252/embr.202255483
EMBO reports, 24(1):e55483. Wiley-Blackwell
EMBO Reports, 24(1):e55483. Wiley-Blackwell

Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration ‘hotspot’ regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e948a7eee2654f8daa2c0cb6818aa
https://research.vumc.nl/en/publications/977802a3-56bf-40d5-8031-092edf437de6

Beclin 1 Interacts With Active Caspase-3 and Bax in Oocytes From Atretic Follicles in the Rat Ovary

Autor: Luis Sánchez-Sánchez, María L. Escobar, Sebastián Palacios-Martínez, Olga M. Echeverría, Silvia Juárez-Chavero, Gerardo H. Vázquez-Nin

Publikováno v: J Histochem Cytochem

Oocyte cell death is a normal process in the mammalian ovary during follicular growth. Recent reports have demonstrated the presence of pro-apoptotic and pro-autophagic proteins during oocyte elimination. The goal of this study was to identify the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d7883b24bc570ea554948c17b40b2f
https://pubmed.ncbi.nlm.nih.gov/31583941