Zobrazeno 1 - 10
of 6 432
pro vyhledávání: '"Sebald"'
Autor:
Michelle A. E. Anderson, Estela Gonzalez, Matthew P. Edgington, Joshua X. D. Ang, Deepak-Kumar Purusothaman, Lewis Shackleford, Katherine Nevard, Sebald A. N. Verkuijl, Timothy Harvey-Samuel, Philip T. Leftwich, Kevin Esvelt, Luke Alphey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Aedes aegypti is the main vector of several major pathogens including dengue, Zika and chikungunya viruses. Classical mosquito control strategies utilizing insecticides are threatened by rising resistance. This has stimulated interest in new
Externí odkaz:
https://doaj.org/article/614c159f168f4a098969285fcd6be9c7
Autor:
Michelle A. E. Anderson, Estela Gonzalez, Joshua X. D. Ang, Lewis Shackleford, Katherine Nevard, Sebald A. N. Verkuijl, Matthew P. Edgington, Tim Harvey-Samuel, Luke Alphey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to mosquito control. Here the authors use transgenic lines with germline-specific regulatory elements to express Cas9 and achieve up to 94% inheritance bias, closing the ga
Externí odkaz:
https://doaj.org/article/64ff3dc761bd47ec983ffd6d6793279c
Autor:
Sebald A. N. Verkuijl, Estela Gonzalez, Ming Li, Joshua X. D. Ang, Nikolay P. Kandul, Michelle A. E. Anderson, Omar S. Akbari, Michael B. Bonsall, Luke Alphey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Here the authors use gene linkage to show that in males inheritance bias of wGDe did not occur by homing, rather through increased propagation of the donor drive elem
Externí odkaz:
https://doaj.org/article/1a66b64f96604774b186ba32c58f94a4
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010370 (2022)
The introgression of genetic traits through gene drive may serve as a powerful and widely applicable method of biological control. However, for many applications, a self-perpetuating gene drive that can spread beyond the specific target population ma
Externí odkaz:
https://doaj.org/article/67791b230e0b4fd7bd6e113b589acb69
Autor:
Bäumler W, Sebald M, Einspieler I, Schicho A, Schaible J, Wiggermann P, Dollinger M, Stroszczynski C, Beyer LP
Publikováno v:
Cancer Management and Research, Vol Volume 12, Pp 8425-8433 (2020)
Wolf Bäumler,1 Mareike Sebald,2 Ingo Einspieler,1 Andreas Schicho,1 Jan Schaible,1 Philipp Wiggermann,3 Marco Dollinger,1 Christian Stroszczynski,1 Lukas Philipp Beyer4 1Department of Radiology, University Hospital Regensburg, Regensburg, Germany; 2
Externí odkaz:
https://doaj.org/article/887349b93c64493e8ab47ab09530bed0
Autor:
Sebald A. N. Verkuijl, Joshua X. D. Ang, Luke Alphey, Michael B. Bonsall, Michelle A. E. Anderson
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Making discrete and precise genetic changes to wild populations has been proposed as a means of addressing some of the world’s most pressing ecological and public health challenges caused by insect pests. Technologies that would allow this, such as
Externí odkaz:
https://doaj.org/article/8feba7854d1f42a891e515ee028d526f
Autor:
Joshua Xin De Ang, Katherine Nevard, Rebekah Ireland, Deepak-Kumar Purusothaman, Sebald A N Verkuijl, Lewis Shackleford, Estela Gonzalez, Michelle A E Anderson, Luke Alphey
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010060 (2022)
The increasing prevalence of insecticide resistance and the ongoing global burden of vector-borne diseases have encouraged new efforts in mosquito control. For Aedes aegypti, the most important arboviral vector, integration rates achieved in Cas9-bas
Externí odkaz:
https://doaj.org/article/1897889efdaa4e57985f4b1d0f8391dc
Autor:
Roya Elaine Haghighat-Khah, Tim Harvey-Samuel, Sanjay Basu, Oliver StJohn, Sarah Scaife, Sebald Verkuijl, Erica Lovett, Luke Alphey
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 9, p e0007579 (2019)
BACKGROUND:Population suppression through mass-release of Aedes aegypti males carrying dominant-lethal transgenes has been demonstrated in the field. Where population dynamics show negative density-dependence, suppression can be enhanced if lethality
Externí odkaz:
https://doaj.org/article/ce07e7e60b2544038bb4e6623d3842b2
