Výsledky vyhledávání - "Seb Lamprecht"

The effects of streptokinase in a Chacma baboon (Papio ursinus) model of acquired thrombotic thrombocytopenic purpura

Autor: Seb Lamprecht, W J Janse van Rensburg, S M Meiring, Jaco Joubert, C Conradie

Publikováno v: Clinical and Experimental Medicine. 21:663-674

TTP is a life-threatening disorder with limited pharmaceutical treatment options. Recently, the potential of streptokinase in the treatment of acquired TTP was demonstrated in humans in vitro, and in vivo in a mouse model. We aimed to determine the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23e755241dfc840cf7ddaa361ffa91da
https://doi.org/10.1007/s10238-021-00711-1

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N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

Autor: Charlotte Dekimpe, Hans Deckmyn, Inge Pareyn, José A. López, Seb Lamprecht, Simon F. De Meyer, Barbara Plaimauer, J. P. Roodt, Claudia Tersteeg, Aline Vandenbulcke, Karen Vanhoorelbeke, Walter J. Janse van Rensburg, Nele Vandeputte

Thrombotic thrombocytopenic purpura (TTP) is a microangiopathic disorder diagnosed by thrombocytopenia and hemolytic anemia, associated with a deficiency in von Willebrand factor (VWF) cleaving protease ADAMTS13. Current treatment is based on plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32da13e9cd2830342a1ff9908e26f6a
http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=28011677

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Inhibition of von Willebrand factor–platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

Autor: Karen Vanhoorelbeke, Walter J. Janse van Rensburg, Inge Pareyn, J. P. Roodt, Hans Deckmyn, Sam Hou, Harald Mottl, Nele Vandeputte, Seb Lamprecht, Hendrik B. Feys

Publikováno v: Blood. 120:3611-3614

The pathophysiology of thrombotic thrombocytopenic purpura (TTP) can be explained by the absence of active ADAMTS13, leading to ultra-large von Willebrand factor (UL-VWF) multimers spontaneously interacting with platelets. Preventing the formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5daea88b4aec6765b5e1e0270fdb0cc5
https://doi.org/10.1182/blood-2012-04-421248

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Rational humanization of the powerful antithrombotic anti-GPIbα antibody: 6B4

Autor: Muriel Meiring, Seb Lamprecht, Johan Desmet, Alexandre Fontayne, Isabel Van Rompaey, Inge Pareyn, Karen Vanhoorelbeke, Hans Deckmyn, J. P. Roodt

Publikováno v: Thrombosis and Haemostasis. 96:671-684

SummaryFab-fragments of the monoclonal antibody 6B4, raised against human glycoprotein Ibα (GPIbα), have a powerful antithrombotic effect in baboons by blocking the GPIbα binding site for von Willebrand factor (VWF), without significant prolongati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::999af69fbf55aa17d3dcbf35a8b37c87
https://doi.org/10.1160/th06-06-0297

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Antithrombotic Effect of Platelet Glycoprotein Ib–Blocking Monoclonal Antibody Fab Fragments in Nonhuman Primates

Autor: Harry F. Kotze, Levente Novák, Seb Lamprecht, J. P. Roodt, S Vauterin, Muriel Meiring, Jolan Harsfalvi, Hans Deckmyn, Nancy Cauwenberghs, Veronika van Wyk

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 20:1347-1353

Abstract —Platelet adhesion in arterial blood flow is mainly supported by the platelet receptor glycoprotein (GP) Ib, which interacts with von Willebrand factor (vWF) that is bound to collagen at the site of vessel wall injury. Antibody 6B4 is a mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f8774056246a5cba742ec59cafaeaa
https://doi.org/10.1161/01.atv.20.5.1347

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Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura

Autor: Seb Lamprecht, J. P. Roodt, Josefin-Beate Holz, Wouter Willems, Thomas Stohr, Hans Ulrichts, Stefaan Rossenu, Filip Callewaert, Walter J. Janse van Rensburg, Sofie Priem

Publikováno v: Blood. 120(17)

ALX-0681 is a therapeutic Nanobody targeting the A1-domain of VWF. It inhibits the interaction between ultra-large VWF and platelet GpIb-IX-V, which plays a crucial role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP). In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e800d5f5875d6ebec958a34372de9f6
https://pubmed.ncbi.nlm.nih.gov/22948047

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Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus)

Autor: Vernon J. Louw, Karen Vanhoorelbeke, Patricia J. Anderson, Inge Pareyn, Ulrich Budde, Hendrik B. Feys, J. P. Roodt, Hans Deckmyn, Seb Lamprecht, Walter J. Janse van Rensburg, Philip N. Badenhorst, Nele Vandeputte

Thrombotic thrombocytopenic purpura (TTP) is the prototypical microangiopathy characterized by disseminated microthromboses, hemolytic anemia, and ultimately organ dysfunction. A link with deficiency of the von Willebrand factor (VWF) cleaving protea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231f1cf3ba914eb2f345702e80983463
http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=20551375

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The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons

Autor: J. P. Roodt, Muriel Meiring, Philippe Barbeaux, Eddy Demarsin, Alexandre Fontayne, Seb Lamprecht, Hans Deckmyn

Publikováno v: Thrombosis and haemostasis. 100(4)

SummaryThe Fab-fragment of 6B4, a murine monoclonal antibody targeting the human platelet glycoprotein (GP) Ibα and blocking the binding of von Willebrand factor (VWF), is a powerful antithrombotic. In baboons, this was without side effects such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5d8ce5a079a5200bad2ae434fb9f54
https://pubmed.ncbi.nlm.nih.gov/18841291

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Rational humanization of the powerful antithrombotic anti-GPIbalpha antibody: 6B4

Autor: Alexandre, Fontayne, Karen, Vanhoorelbeke, Inge, Pareyn, Isabel, Van Rompaey, Muriel, Meiring, Seb, Lamprecht, Jan, Roodt, Johan, Desmet, Hans, Deckmyn

Publikováno v: Thrombosis and haemostasis. 96(5)

Fab-fragments of the monoclonal antibody 6B4, raised against human glycoprotein Ibalpha (GPIbalpha), have a powerful antithrombotic effect in baboons by blocking the GPIbalpha binding site for von Willebrand factor (VWF), without significant prolonga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d4caf3820831a405d679d5367e97a31
https://pubmed.ncbi.nlm.nih.gov/17080226

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ALX-0081 Nanobody™, an Engineered Bivalent Anti-Thrombotic Drug Candidate with Improved Efficacy and Safety as Compared to the Marketed Drugs

Autor: Peter Casteels, J. P. Roodt, Bob van der Jeugt, Flip G. de Groot, Karen Silence, Torsten Dreier, Muriel Meiring, M. J. W. Ijsseldijk, Kristi de Smet, Seb Lamprecht, Heidi Maria Florence Jonckheere

Publikováno v: Blood. 108:896-896

In patients with plaque rupture, platelets adhere, aggregate and form a thrombus. Current strategies to prevent thrombus formation consist of the use of Aspirin®, Plavix® and integrin αIIbβ3 blockers (e.g. Reopro®) in combination with Heparin®.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4ed7d9fd9afe74ceea94e83d18ebb12
https://doi.org/10.1182/blood.v108.11.896.896

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