Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Seb J. Carey"'
Autor:
Elizabeth M. Amphlett, Martin R. Johnson, Gail Mills, Martin John Slater, Nigel R. Parry, Seb J. Carey, Donald O. Somers, Tadeusz Skarzynski, Alan J. W. Stewart, Paul Bamborough, David M. Andrews, Paul Spencer Jones
Publikováno v:
Organic Letters. 5:4627-4630
[reaction: see text] In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors based upon the pyrrolidine-5,5-trans-lactam template. Compound 7b demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09854488289a3d17fc7674c0650f85ac
https://doi.org/10.1021/ol035826v
https://doi.org/10.1021/ol035826v
Autor:
Gail Mills, Graham Baker, Paul Jones, Ed Robinson, David M. Andrews, Norman M. Gray, Berwyn Clarke, Susanne S. Bethell, Seb J. Carey, Coomber Ba, George Hardy, Martin John Slater, Andrew Good, Malcolm Ellis, Helene M. Chaignot
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3359-3362
Using a pyrrolidine-5,5- trans -lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 11a , with an alpha-ethyl P1 substituent and a Boc-valine substituent at the pyrrolidine nitrogen, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d478e26f4966ae307d5b896069c2e2
https://doi.org/10.1016/s0960-894x(02)00789-8
https://doi.org/10.1016/s0960-894x(02)00789-8
Autor:
Seb J. Carey, Hind Sl, Helene M. Chaignot, Martin John Slater, David M. Andrews, Paul Spencer Jones, Robinson Je, Gail Mills, Norman M. Gray, Coomber Ba
Publikováno v:
Organic letters. 4(25)
[reaction: see text] In this, the first of two letters, we outline the use of the pyrrolidine-5,5-trans-lactam template to design small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. The hitherto unreported reaction of the acyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8af4d401b5c17ed875f5a69f0a3c14b
https://pubmed.ncbi.nlm.nih.gov/12465916
https://pubmed.ncbi.nlm.nih.gov/12465916