Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Seav Huong Ly"'
Autor:
Justin H. Hwang, Ji-Heui Seo, Michael L. Beshiri, Stephanie Wankowicz, David Liu, Alexander Cheung, Ji Li, Xintao Qiu, Andrew L. Hong, Ginevra Botta, Lior Golumb, Camden Richter, Jonathan So, Gabriel J. Sandoval, Andrew O. Giacomelli, Seav Huong Ly, Celine Han, Chao Dai, Hubert Pakula, Anjali Sheahan, Federica Piccioni, Ole Gjoerup, Massimo Loda, Adam G. Sowalsky, Leigh Ellis, Henry Long, David E. Root, Kathleen Kelly, Eliezer M. Van Allen, Matthew L. Freedman, Atish D. Choudhury, William C. Hahn
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2355-2370.e6 (2019)
Summary: Androgen-receptor (AR) inhibitors, including enzalutamide, are used for treatment of all metastatic castration-resistant prostate cancers (mCRPCs). However, some patients develop resistance or never respond. We find that the transcription fa
Externí odkaz:
https://doaj.org/article/40f707e6f0e3479da1c48a8eaa450461
Autor:
Ji Li, Peter S Choi, Christine L Chaffer, Katherine Labella, Justin H Hwang, Andrew O Giacomelli, Jong Wook Kim, Nina Ilic, John G Doench, Seav Huong Ly, Chao Dai, Kimberly Hagel, Andrew L Hong, Ole Gjoerup, Shom Goel, Jennifer Y Ge, David E Root, Jean J Zhao, Angela N Brooks, Robert A Weinberg, William C Hahn
Publikováno v:
eLife, Vol 7 (2018)
Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse functions. In a genome-scale expression screen for inducers of the epithelial-to-mesenchymal
Externí odkaz:
https://doaj.org/article/065b7c78b0bc49f4914d3e34a00422d9
Autor:
Oana Ursu, James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Lan Nguyen, Danielle Dionne, Celeste Diaz, Julia Bauman, Mariam Mounir Mosaad, Christian Fagre, April Lo, Maria McSharry, Andrew O. Giacomelli, Seav Huong Ly, Orit Rozenblatt-Rosen, William C. Hahn, Andrew J. Aguirre, Alice H. Berger, Aviv Regev, Jesse S. Boehm
Publikováno v:
Nature Biotechnology. 40:1691-1691
Autor:
Andrew O. Giacomelli, William C. Hahn, Julia Bauman, Orit Rozenblatt-Rosen, Andrew J. Aguirre, Lan Nguyen, Jesse S. Boehm, Emily K Shea, Seav Huong Ly, Pratiksha I. Thakore, Danielle Dionne, Alice H. Berger, Celeste Diaz, James T. Neal, Livnat Jerby-Arnon, Christian R. Fagre, Aviv Regev, Mariam Mounir Mosaad, Oana Ursu
Genome sequencing studies have identified millions of somatic variants in cancer, but their phenotypic impact remains challenging to predict. Current experimental approaches to distinguish between functionally impactful and neutral variants require c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f573fe66aaf4affc6af462a900eb606
https://doi.org/10.1101/2020.11.16.383307
https://doi.org/10.1101/2020.11.16.383307
Autor:
Oana Ursu, James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Lan Nguyen, Danielle Dionne, Celeste Diaz, Julia Bauman, Mariam Mounir Mosaad, Christian Fagre, April Lo, Maria McSharry, Andrew O. Giacomelli, Seav Huong Ly, Orit Rozenblatt-Rosen, William C. Hahn, Andrew J. Aguirre, Alice H. Berger, Aviv Regev, Jesse S. Boehm
Publikováno v:
Nature biotechnology. 40(6)
Genome sequencing studies have identified millions of somatic variants in cancer, but it remains challenging to predict the phenotypic impact of most. Experimental approaches to distinguish impactful variants often use phenotypic assays that report o
Autor:
Miju Kim, Seav Huong Ly, Yingtian Xie, Gina N. Duronio, Dane Ford-Roshon, Justin H. Hwang, Rita Sulahian, Jonathan P. Rennhack, Jonathan So, Ole Gjoerup, Jessica A. Talamas, Maximilien Grandclaudon, Henry W. Long, John G. Doench, Nilay S. Sethi, Marios Giannakis, William C. Hahn
Publikováno v:
Dev Cell
The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration, and tumorigenesis. Multiple cancers are dependent on sustained expression of YAP1 for cell p
Autor:
Jonathan So, Kathleen Kelly, Ole Gjoerup, David E. Root, Alexander T. M. Cheung, Camden Richter, Adam G. Sowalsky, Ginevra Botta, Matthew L. Freedman, Ji Li, Eliezer M. Van Allen, Michael L. Beshiri, Federica Piccioni, Justin H. Hwang, Henry W. Long, Andrew L. Hong, Andrew O. Giacomelli, Celine Han, Seav Huong Ly, Massimo Loda, Hubert Pakula, Anjali V. Sheahan, Atish D. Choudhury, Chao Dai, Stephanie A. Wankowicz, David Liu, Ji-Heui Seo, Gabriel J. Sandoval, Lior Golumb, Leigh Ellis, William C. Hahn, Xintao Qiu
Publikováno v:
Cell reports
Cell Reports, Vol 29, Iss 8, Pp 2355-2370.e6 (2019)
Cell Reports, Vol 29, Iss 8, Pp 2355-2370.e6 (2019)
SUMMARY Androgen-receptor (AR) inhibitors, including enzalutamide, are used for treatment of all metastatic castration-resistant prostate cancers (mCRPCs). However, some patients develop resistance or never respond. We find that the transcription fac
Autor:
Shom Goel, Nina Ilic, Jong Wook Kim, John G. Doench, Ole Gjoerup, Andrew L. Hong, Justin H. Hwang, Peter S. Choi, Jean J. Zhao, Kimberly Hagel, Chao Dai, Jennifer Y Ge, William C. Hahn, Ji Li, Katherine Labella, Angela N. Brooks, David E. Root, Christine L. Chaffer, Robert A. Weinberg, Andrew O. Giacomelli, Seav Huong Ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b66161f754b004946b9519aebabc3a
https://doi.org/10.7554/elife.37184.034
https://doi.org/10.7554/elife.37184.034
Autor:
William C. Hahn, Jong Wook Kim, Katherine Labella, Jennifer Y Ge, Ji Li, Andrew L. Hong, Andrew O. Giacomelli, Jean J. Zhao, Seav Huong Ly, John G. Doench, Ole Gjoerup, Christine L. Chaffer, Shom Goel, Chao Dai, Kimberly Hagel, Angela N. Brooks, Robert A. Weinberg, David E. Root, Nina Ilic, Justin H. Hwang, Peter S. Choi
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse functions. In a genome-scale expression screen for inducers of the epithelial-to-mesenchymal
Autor:
Andrew O. Giacomelli, John G. Doench, Ole Gjoerup, Seav Huong Ly, Jong Wook Kim, Justin H. Hwang, Peter S. Choi, Chao Dai, Robert A. Weinberg, Matthew Meyerson, Ji Li, Angela N. Brooks, Christine L. Chaffer, Nina Ilic, Andrew L. Hong, William C. Hahn, Katherine Labella
Publikováno v:
Molecular Cancer Therapeutics. 16:A36-A36
Epithelial-mesenchymal transition (EMT) is an essential developmental program and is often reactivated during tumor initiation and progression. EMT is a reversible reprogramming of the cells. It not only promotes cell morphology alterations, but also