Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Seang Yiv"'
Autor:
Ingrid Cely, Fatih M. Uckun, Jianjun Cheng, Anoush Shahidzadeh, Seang Yiv, Qian Yin, Sanjive Qazi, Paul S. Gaynon, Ibrahim Hanifi Ozercan, Kazim Sahin, Amanda Termuhlen
Publikováno v:
Blood. 121:4348-4354
We report preclinical proof of principle for effective treatment of B-precursor acute lymphoblastic leukemia (ALL) by targeting the spleen tyrosine kinase (SYK)-dependent antiapoptotic blast cell survival machinery with a unique nanoscale pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3f6c542ec4aa5f16f1d77d0b90177c
https://doi.org/10.1182/blood-2012-11-470633
https://doi.org/10.1182/blood-2012-11-470633
Publikováno v:
Arzneimittelforschung. 60:210-217
WHI-P131 (CAS 202475-60-3) is a dual-function inhibitor of JAK3 tyrosine kinase that demonstrated potent in vivo anti-inflammatory and anti-leukemic activity in several preclinical animal models. This is the first report of the development of nanopar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa8d2944f56d410b9e02f5b8f30d0fd
https://doi.org/10.1055/s-0031-1296275
https://doi.org/10.1055/s-0031-1296275
Autor:
Sanjive Qazi, Fatih M. Uckun, Amanda M. Termuhlen, Martha Arellano, Hong Ma, Ingrid Cely, Jianjun Cheng, Anoush Shahidzadeh, Dorothea E. Myers, Seang Yiv, Erin Finestone, Paul S. Gaynon
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro. 6(8)
We report the anti-leukemic potency of a unique biotargeted nanoscale liposomal nanoparticle (LNP) formulation of the spleen tyrosine kinase (SYK) P-site inhibitor C61. C61-loaded LNP were decorated with a murine CD19-specific monoclonal antibody dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec63e7c36e680038b6090fc8a9b2f5c
https://pubmed.ncbi.nlm.nih.gov/24910947
https://pubmed.ncbi.nlm.nih.gov/24910947
Publikováno v:
Journal of Applied Toxicology. 20:319-325
Heterosexual transmission of human immunodeficiency virus (HIV) accounts for 90% of all new infections worldwide and significantly contributes to new acquired immunodeficiency syndrome (AIDS) cases in the USA. In a systematic effort to develop a micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19cb44fc2e28302510f2eed78cd92c9d
https://doi.org/10.1002/1099-1263(200007/08)20:4<319::aid-jat696>3.0.co
https://doi.org/10.1002/1099-1263(200007/08)20:4<319::aid-jat696>3.0.co
Publikováno v:
Molecular Human Reproduction. 5:421-432
In a systematic effort to develop a microbicide contraceptive capable of preventing transmission of human immunodeficiency virus (HIV), as well as providing fertility control, we have previously identified novel phenyl phosphate derivatives of zidovu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9549101862c1fb559e6b0ccf4694c5b9
https://doi.org/10.1093/molehr/5.5.421
https://doi.org/10.1093/molehr/5.5.421
The pentapeptide mimic 1,4-bis(9-O-dihydroquinidinyl)phthalazine / hydroquinidine 1,4-phathalazinediyl diether ("compound 61") (C-61) is the first reported inhibitor targeting the P-site of SYK. Here we report a nanotechnology platform to target C-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1605066d736f2e98fe46eab13f30ea83
https://europepmc.org/articles/PMC3668349/
https://europepmc.org/articles/PMC3668349/
Publikováno v:
Expert opinion on investigational drugs. 21(3)
A focal point in contemporary research aimed at preventing the heterosexual spread of AIDS has been the development of intravaginal anti-HIV microbicides to curb the mucosal human immunodeficiency virus type 1 (HIV-1) transmission.This article review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812c2369839cb8fd387600be759d6e0b
https://pubmed.ncbi.nlm.nih.gov/22292483
https://pubmed.ncbi.nlm.nih.gov/22292483
Publikováno v:
Journal of Nanomedicine & Nanotechnology.
The quinazoline derivative 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131/JANEX-1; CAS 202475-60-3) is a dual-function inhibitor of Janus kinase 3 (JAK3) and Epidermal Growth Factor (EGF) receptor kinase. A PEGylated liposomal nanopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b10686e920e2341273a7f4bdc8a3cf
https://doi.org/10.4172/2157-7439.1000101
https://doi.org/10.4172/2157-7439.1000101
Publikováno v:
AAPS PharmSciTech. 2(2)
In a systematic effort to develop a dual-function intravaginal spermicide as well as a drug delivery vehicle against sexually transmitted pathogens, a submicron particle size (30-80 nm), lipophilic and spermicidal gel-microemulsion (viz GM-144) conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726852821dd9cc122841e9de52fa97f2
https://pubmed.ncbi.nlm.nih.gov/14727880
https://pubmed.ncbi.nlm.nih.gov/14727880
Publikováno v:
Fertility and sterility. 75(1)
Objective: To investigate the in vivo contraceptive potency and safety of a novel microemulsion-based lipophilic vaginal spermicide. Design: In vitro and in vivo spermicidal activity and safety of a submicron-particle-size, lipophilic gel–microemul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d1ed21aa25c65a332d104b68a92a5f
https://pubmed.ncbi.nlm.nih.gov/11163825
https://pubmed.ncbi.nlm.nih.gov/11163825